# Sytrinol (Polymethoxylated Flavones)

**Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/sytrinol
**Data Source:** Hermetica Superfoods Ingredient Encyclopedia
**Updated:** 2026-04-04
**Evidence Score:** 2 / 10
**Category:** Other
**Also Known As:** PMFs, Polymethoxylated Flavones, Citrus Polymethoxylated Flavones, Citrus PMFs, Orange Peel Flavones, Citrus sinensis Extract, Citrus paradisi Extract, Standardized Citrus Flavonoids

## Overview

Sytrinol is a patented blend of polymethoxylated flavones (PMFs) — primarily tangeretin and nobiletin — derived from citrus peel, combined with palm tocotrienols. It lowers cholesterol and triglycerides by inhibiting hepatic lipid synthesis enzymes and reducing apolipoprotein B secretion.

## Health Benefits

• Reduces total cholesterol by 20-30% in hypercholesterolemic adults (Strong evidence from 12-week RCT, n=120)
• Lowers [LDL cholesterol](/ingredients/condition/heart-health) by 19-27% (Strong evidence from double-blind RCT)
• Decreases triglycerides by 24-34% (Strong evidence from clinical trials)
• Reduces apolipoprotein B levels by 21% (Moderate evidence from one RCT)
• Maintains or slightly increases HDL cholesterol levels (Moderate evidence from clinical studies)

## Mechanism of Action

Sytrinol's polymethoxylated flavones — tangeretin and nobiletin — suppress hepatic de novo lipogenesis by downregulating sterol regulatory element-binding protein-1c (SREBP-1c) and inhibiting HMG-CoA reductase activity, reducing endogenous cholesterol synthesis. The PMFs also decrease microsomal triglyceride transfer protein (MTP) activity, impairing VLDL assembly and apolipoprotein B-100 secretion from hepatocytes. Palm tocotrienols in the formula provide complementary HMG-CoA reductase suppression via post-transcriptional mechanisms distinct from statin pathways.

## Clinical Summary

A 12-week randomized, double-blind, placebo-controlled trial (n=120) in hypercholesterolemic adults demonstrated that Sytrinol at 300 mg/day reduced total cholesterol by 20–30%, [LDL cholesterol](/ingredients/condition/heart-health) by 19–27%, and triglycerides by 24–34% compared to baseline. Apolipoprotein B levels declined by approximately 21%, reflecting reduced atherogenic particle output. Evidence quality is strong for lipid-lowering endpoints given the RCT design, though long-term cardiovascular outcome data beyond 12 weeks remain limited. Independent replication in larger, multi-center trials is needed to confirm magnitude of effect across diverse populations.

## Nutritional Profile

Sytrinol is a patented, standardized extract composed primarily of polymethoxylated flavones (PMFs) derived from citrus peel (primarily sweet orange, Citrus sinensis) combined with tocotrienols from palm fruit (Elaeis guineensis). Key bioactive compounds include: Tangeretin (primary PMF, ~30-40% of PMF fraction), Nobiletin (~20-30% of PMF fraction), Sinensetin and other minor PMFs (~10-15%), and mixed tocotrienols (alpha, beta, gamma, delta isoforms, ~20-30% of total extract). Typical standardized dosage used in clinical trials is 300 mg/day total extract. PMF concentration in commercial Sytrinol is standardized to approximately 50-60% total polymethoxylated flavones by weight. Tocotrienol content is approximately 40-50% of extract weight. Sytrinol contains no significant macronutrients (protein, fat, carbohydrate), dietary fiber, or conventional vitamins and minerals at functional doses. Bioavailability: PMFs are lipophilic compounds with moderate oral bioavailability; absorption is enhanced when taken with dietary fat. Tangeretin and nobiletin undergo hepatic first-pass [metabolism](/ingredients/condition/weight-management) via CYP450 enzymes (primarily CYP3A4) and undergo enterohepatic recirculation. Tocotrienols exhibit superior bioavailability compared to tocopherols due to distinct hepatic metabolism. Half-life of PMFs is estimated at 4-6 hours. The synergistic combination of PMFs and tocotrienols in Sytrinol is proposed to enhance lipid-modulating efficacy beyond either component alone, primarily through inhibition of HMG-CoA reductase and ACAT (acyl-CoA:cholesterol acyltransferase) activity.

## Dosage & Preparation

Clinically studied dosage: 270 mg citrus PMFs standardized to polymethoxylated flavones plus 30 mg tocotrienols daily, divided into doses with meals. Duration: 4-12 weeks as studied in hypercholesterolemic subjects. Available in powder/capsule forms. Consult a healthcare provider before starting any new supplement.

## Safety & Drug Interactions

Sytrinol is generally well tolerated in short-term studies up to 12 weeks, with no significant adverse events reported at the standard 300 mg/day dose. Because PMFs are metabolized via CYP3A4 and CYP1A2 hepatic enzymes, caution is warranted when combining Sytrinol with statins, warfarin, or other CYP450-substrate drugs, as competitive inhibition may alter drug plasma levels. Pregnant and breastfeeding women should avoid Sytrinol due to insufficient safety data, and individuals with citrus allergies should consult a physician before use. Those already taking lipid-lowering medications should seek medical supervision to monitor for additive hypocholesterolemic effects.

## Scientific Research

The primary clinical evidence for Sytrinol comes from a randomized controlled trial (PMID: 17985810) that included two open-label studies (n=10 each) and one 12-week double-blind RCT (n=120) in hypercholesterolemic adults. The combination of 270 mg citrus PMFs plus 30 mg tocotrienols showed significant lipid improvements versus placebo.

## Historical & Cultural Context

No traditional or historical medicinal use was identified for Sytrinol in the research, as it is a modern branded extract developed specifically for cholesterol management. Unlike whole citrus fruits used in traditional medicine, Sytrinol represents a concentrated, standardized preparation of specific citrus peel compounds.

## Synergistic Combinations

Tocotrienols, Red Yeast Rice, Plant Sterols, Omega-3 Fatty Acids, Artichoke Leaf Extract

## Frequently Asked Questions

### What is the recommended dosage of Sytrinol for cholesterol management?

Clinical trials supporting Sytrinol's cholesterol-lowering effects used a standardized dose of 300 mg per day, typically taken as a single dose or split into two 150 mg doses with meals. This dose provided reductions of 20–30% in total cholesterol and 24–34% in triglycerides over 12 weeks. Doses above 300 mg/day have not been well studied, so exceeding this amount without medical guidance is not recommended.

### How long does Sytrinol take to lower cholesterol?

In the primary 12-week RCT, statistically significant reductions in LDL cholesterol and triglycerides were observed within the study period at 300 mg/day. Some users may notice measurable lipid changes within 4–6 weeks based on the supplement's mechanism of inhibiting SREBP-1c-driven hepatic lipid synthesis, but peak effects generally emerge at the 12-week mark. Consistent daily use alongside dietary modifications yields the most reliable outcomes.

### Can Sytrinol be taken with statins like atorvastatin?

Combining Sytrinol with statins such as atorvastatin or simvastatin may produce additive LDL-lowering effects, since both inhibit HMG-CoA reductase through complementary mechanisms — statins competitively and PMFs post-transcriptionally. However, Sytrinol's PMFs can inhibit CYP3A4, the enzyme responsible for metabolizing many statins, potentially raising statin plasma concentrations and increasing the risk of myopathy or liver enzyme elevation. Anyone on statin therapy should consult their physician before adding Sytrinol.

### Is Sytrinol effective for lowering triglycerides specifically?

Yes, Sytrinol demonstrates particularly robust effects on triglycerides, with clinical evidence showing reductions of 24–34% at 300 mg/day over 12 weeks. This effect is attributed to inhibition of microsomal triglyceride transfer protein (MTP), which impairs hepatic VLDL-triglyceride assembly and secretion. This mechanism makes Sytrinol a candidate adjunct for individuals with hypertriglyceridemia, though it should not replace prescribed fibrates or omega-3 therapies without physician approval.

### What makes Sytrinol different from other citrus flavonoid supplements like bergamot?

Sytrinol is specifically standardized to polymethoxylated flavones — tangeretin and nobiletin — plus palm tocotrienols, whereas bergamot extract is rich in hydroxylated flavonoids such as brutieridin and melitidin, which act more directly as HMG-CoA reductase competitive inhibitors similar to statins. Sytrinol's PMFs are more lipophilic than bergamot's flavanones, giving them greater cell membrane penetration and SREBP-1c suppression activity. Both show cholesterol-lowering effects in clinical trials, but their molecular targets and supporting evidence bases differ meaningfully.

### Is Sytrinol safe for long-term use?

Clinical trials have demonstrated the safety of Sytrinol in studies lasting up to 12 weeks with no serious adverse events reported. While long-term safety data beyond 12 weeks is limited, Sytrinol is derived from citrus peel polymethoxylated flavones, which are naturally occurring compounds with a favorable safety profile. Individuals with known citrus allergies or those taking blood-thinning medications should consult a healthcare provider before use.

### Can Sytrinol be taken with other supplements for cholesterol management?

Sytrinol can generally be combined with other natural cholesterol-support ingredients like plant sterols, red yeast rice, or niacin, though combining multiple cholesterol-lowering agents may increase the potential for additive effects. It is important to inform your healthcare provider about all supplements you are taking, especially if you are also using prescription medications or other lipid-lowering supplements. Starting with Sytrinol alone and monitoring lipid panel results is often recommended before adding additional cholesterol support supplements.

### What is the mechanism by which Sytrinol lowers cholesterol?

Sytrinol's polymethoxylated flavones work by inhibiting the synthesis of apolipoprotein B (apoB), a key protein required for the production and secretion of VLDL and LDL particles from the liver. This mechanism is distinct from statins, which work by inhibiting HMG-CoA reductase, making Sytrinol potentially useful as a complementary approach to cholesterol management. Additionally, these flavones may enhance the clearance of LDL particles from the bloodstream and support beneficial changes in triglyceride metabolism.

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*Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com*
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