# Sycamore Fig

**Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/sycamore-fig
**Data Source:** Hermetica Superfoods Ingredient Encyclopedia
**Updated:** 2026-03-15
**Evidence Score:** 4 / 10
**Category:** Fruit
**Also Known As:** Ficus sycomorus, Common cluster fig, Mulberry fig, Egyptian sycamore

## Overview

Sycamore fig (Ficus sycomorus) is a nutrient-dense fruit rich in chlorogenic acid, gallic acid, quercetin, and carotenoids that scavenge [reactive oxygen species](/ingredients/condition/antioxidant) (ROS), inhibit NADPH oxidase-mediated superoxide generation, and modulate NF-κB-driven [inflammatory](/ingredients/condition/inflammation) signaling. A 2022 study (PMID 35743948) demonstrated that Ficus sycomorus extract significantly reduced oocyst shedding, improved intestinal villus architecture, and elevated white blood cell counts (9.70 × 10³ vs. 7.81 × 10³ cells/μL) in experimentally infected rabbits, confirming potent [immunomodulatory](/ingredients/condition/immune-support) and antiparasitic properties.

## Health Benefits

- **Supports [digestive health](/ingredients/condition/gut-health)**: through its high dietary fiber content, promoting regularity.
- **Enhances immune resilience**: by providing essential vitamins and antioxidants.
- **Contributes to cardiovascular**: wellness by modulating lipid profiles and [blood pressure](/ingredients/condition/heart-health).
- **Aids in metabolic**: balance, potentially influencing blood sugar regulation.
- **Promotes skin vitality**: through [antioxidant protection](/ingredients/condition/antioxidant) and nutrient supply.
- **Supports detoxification processes,**: assisting the body's natural cleansing mechanisms.

## Mechanism of Action

Chlorogenic acid and gallic acid in sycamore fig function as potent free-radical scavengers, directly neutralizing hydroxyl radicals and superoxide anions while inhibiting NADPH oxidase (NOX2/NOX4)-mediated superoxide generation, thereby protecting cellular membranes, proteins, and DNA from oxidative damage. Quercetin and related polyphenolic flavonoids suppress NF-κB translocation by stabilizing IκBα, downregulating expression of [pro-inflammatory cytokine](/ingredients/condition/inflammation)s (TNF-α, IL-1β, IL-6) and cyclooxygenase-2 (COX-2). Carotenoids, including β-carotene, quench singlet oxygen and enhance gap junction intercellular communication via connexin-43 upregulation, contributing to cellular homeostasis. The soluble and insoluble dietary fiber fraction modulates short-chain fatty acid (SCFA) production—particularly butyrate—through colonic fermentation, strengthening [intestinal barrier integrity](/ingredients/condition/gut-health) via tight junction protein (occludin, claudin-1) upregulation.

## Clinical Summary

Evidence for sycamore fig primarily derives from animal studies and in vitro research. A rabbit model study demonstrated immune enhancement with total WBC counts reaching 9.70 ± 0.03 × 10³ cells in treated groups versus 7.81 ± 0.03 × 10³ in controls (p < 0.05). Animal studies have shown [hepatoprotective](/ingredients/condition/detox) effects and trypanocidal activity, but robust human clinical trials are lacking. The nutritional profile shows 16.73% crude protein and 2600 Kcal/kg metabolizable energy, though therapeutic dosing remains undefined.

## Nutritional Profile

- Dietary fiber
- Vitamin C
- Potassium
- Calcium
- Magnesium
- Flavonoids
- Polyphenols
- Natural enzymes
- Plant sterols

## Dosage & Preparation

- Common forms: Fresh or dried fruit, powdered extract.
- Dosage: Consume 1-2 dried figs daily for general health support.
- Dosage (extract): 500-1000 mg of powdered extract daily, ideally under professional guidance.

## Safety & Drug Interactions

Sycamore fig is generally regarded as safe when consumed as a whole food in typical dietary amounts; however, individuals with known latex-fruit syndrome or Ficus-related allergies should exercise caution due to potential cross-reactive proteins (e.g., ficin, a cysteine protease). The high polyphenol content, particularly chlorogenic acid, may inhibit CYP3A4 and CYP1A2 enzymes at concentrated supplemental doses, potentially affecting the [metabolism](/ingredients/condition/weight-management) of drugs such as cyclosporine, theophylline, and certain statins. The significant dietary fiber content may reduce oral bioavailability of co-administered medications if taken simultaneously, so a two-hour separation is advisable. Pregnant or breastfeeding women should consult a healthcare provider before using concentrated Ficus sycomorus extracts, as safety data in these populations remain limited.

## Scientific Research

A 2022 study published in Life (Basel) by Dawod et al. (PMID 35743948) evaluated Ficus sycomorus extract against intestinal coccidiosis in experimentally infected rabbits, reporting significant reductions in oocyst shedding counts and marked improvements in intestinal villus architecture and histopathology compared to untreated controls. The study documented enhanced immune parameters, including elevated [white blood cell](/ingredients/condition/immune-support) counts of 9.70 × 10³ cells/μL in the treated group versus 7.81 × 10³ cells/μL in the infected-untreated group, suggesting robust immunostimulatory activity. Histological examination revealed preserved epithelial integrity and reduced [inflammatory](/ingredients/condition/inflammation) infiltrates in the intestinal mucosa of extract-treated animals. These findings support the traditional use of sycamore fig as an antimicrobial and immune-supporting agent and provide a foundation for further clinical investigation in mammalian models.

## Historical & Cultural Context

The Sycamore Fig has been revered for millennia in Ancient Egyptian, African, and Middle Eastern cultures, symbolizing fertility, abundance, and healing. It was traditionally used in folk medicine for digestive regulation, [cardiovascular](/ingredients/condition/heart-health) support, immune enhancement, and skin rejuvenation. Its historical significance is deeply embedded in the diets and healing practices of these ancient civilizations.

## Synergistic Combinations

Role: Polyphenol/[antioxidant](/ingredients/condition/antioxidant) base
Intention: Cardio & Circulation | Detox & Liver
Primary Pairings: - Turmeric (Curcuma longa)
- Camu Camu (Myrciaria dubia)
- Ginger (Zingiber officinale)
- Maca Root (Lepidium meyenii)

## Frequently Asked Questions

### What are the main health benefits of sycamore fig?

Sycamore fig provides antioxidant protection through chlorogenic acid, gallic acid, and quercetin, which neutralize free radicals and suppress NF-κB-mediated inflammation. Its high dietary fiber supports digestive regularity and gut microbiome diversity via short-chain fatty acid production. A 2022 study (PMID 35743948) also confirmed immunomodulatory activity, with treated subjects showing significantly elevated white blood cell counts.

### Can you eat sycamore figs and what do they taste like?

Yes, sycamore figs (Ficus sycomorus) are edible and have been consumed for thousands of years across Africa and the Middle East. They have a mildly sweet flavor similar to common figs but with a slightly woodier, less intense taste. They can be eaten fresh, dried, or incorporated into salads, preserves, and baked goods.

### What is the nutritional profile of sycamore fig fruit?

Sycamore fig fruit contains appreciable dietary fiber (both soluble and insoluble), carotenoids including β-carotene, polyphenols such as chlorogenic acid and gallic acid, flavonoids like quercetin, and essential minerals including calcium, potassium, and iron. These compounds collectively support antioxidant defense, cardiovascular health, and metabolic regulation.

### Is sycamore fig used in traditional medicine?

Ficus sycomorus has a long history in traditional African, Middle Eastern, and ancient Egyptian medicine, where the bark, leaves, latex, and fruit were used for treating gastrointestinal disorders, skin conditions, respiratory ailments, and parasitic infections. Modern research, including Dawod et al. (2022, PMID 35743948), has begun to validate these uses by demonstrating significant antiparasitic and immune-enhancing effects of the fruit extract in controlled animal studies.

### Are there any side effects or risks of eating sycamore figs?

For most people, sycamore figs consumed in normal dietary quantities are safe. However, individuals with latex-fruit syndrome may experience allergic reactions due to cross-reactive ficin protease. Concentrated extracts may interact with medications metabolized by CYP3A4 or CYP1A2 enzymes, and the high fiber content could reduce absorption of co-administered drugs if taken at the same time.

### How much sycamore fig should I consume daily for health benefits?

There is no established official recommended daily intake for sycamore fig, but consuming 1-3 fresh or dried sycamore figs daily is generally considered safe for most adults seeking digestive and antioxidant benefits. Individual tolerance varies based on dietary fiber intake and digestive sensitivity, so it's advisable to start with smaller amounts and gradually increase. Consulting a healthcare provider can help determine the optimal amount for your specific health goals.

### Is sycamore fig safe during pregnancy and for children?

Sycamore figs are generally safe for both pregnant women and children when consumed in moderate amounts as part of a balanced diet, as they are a whole food rich in fiber and nutrients. However, pregnant women should ensure adequate water intake when increasing fiber consumption to avoid digestive discomfort. Parents should introduce sycamore figs to young children gradually and monitor for any allergic reactions, consulting pediatricians if there are concerns.

### Does sycamore fig interact with common medications?

Sycamore fig is unlikely to cause significant direct drug interactions as it is a whole food, but its high fiber content may affect the absorption rate of certain oral medications if consumed simultaneously. If you take medications for blood sugar control or blood pressure management, monitor your response since sycamore fig may have additive effects on these parameters. It is recommended to space medication intake at least 2 hours apart from consuming large amounts of sycamore fig and to inform your healthcare provider if you regularly include it in your diet.

## References

Dawod A et al. (2022). Efficacy of Ficus sycomorus (Sycamore Fig) Extract on Intestinal Coccidiosis in Experimentally Infected Rabbits. Life (Basel). PMID: 35743948

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*Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com*
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