Hermetica Superfood Encyclopedia
The Short Answer
Squalene is a natural fat-like compound found in olive oil and your own skin that acts as a powerful antioxidant and supports skin hydration, immune function, and cellular health.
CategoryOther
GroupOther
Evidence LevelModerate
Synergy Pairings2
Health Benefits
Supports the biosynthesis of cholesterol, steroid hormones, and vitamin D as a key metabolic intermediate.
Provides potent antioxidant protection by neutralizing free radicals and preventing lipid peroxidation in cell membranes.
Promotes skin hydration, elasticity, and barrier function, offering protection from environmental damage.
Modulates immune response by enhancing macrophage activity and reducing pro-inflammatory cytokines.
Exhibits significant anti-inflammatory effects by suppressing oxidative stress and inflammatory mediators.
Origin & History
Squalene is a naturally occurring triterpene compound, biosynthesized in humans by the liver and skin as a crucial intermediate for cholesterol, steroid hormones, and vitamin D. It is found in high concentrations in shark liver oil, olives, amaranth, and certain plant seeds. Primarily functioning as a biochemical precursor and potent antioxidant, squalene is vital for cellular health.
“In Mediterranean traditions, olive oil, a natural source of squalene, has been revered for millennia for its nourishing and protective qualities for both internal health and skin. Similarly, in Japanese coastal medicine, shark liver oil was historically utilized to boost vitality, foreshadowing squalene’s modern recognition as a potent antioxidant and immune enhancer.”Traditional Medicine
Scientific Research
Squalene is supported by extensive research in dermatology, cardiovascular health, and immunology. Studies demonstrate its efficacy in protecting against oxidative stress, improving skin barrier function, and enhancing vaccine adjuvanticity. Ongoing investigations explore its potential roles in cancer prevention, anti-aging, and broad immune modulation.
Preparation & Dosage
Common forms
Oral supplements (capsules), topical serums, moisturizers.
Dosage
300-1000 mg/day for oral supplementation, or applied topically as needed
Typically .
Sources
Primarily derived from shark liver oil, olives, rice bran, and amaranth seed oil.
Nutritional Profile
- Triterpene compound (C30H50)
- Unsaturated hydrocarbon chains
- High lipophilicity
- Precursor to cholesterol, steroid hormones, and vitamin D
Synergy Stack
Hermetica Formulation Heuristic
Fat + fiber base
Skin & Collagen | Longevity & Anti-Aging
Frequently Asked Questions
What is squalene?
Squalene is a naturally occurring triterpene lipid produced by your liver and skin, and found abundantly in olive oil, amaranth seed oil, and shark liver oil. It serves as a precursor to cholesterol, vitamin D, and steroid hormones, and functions as a potent antioxidant that protects cell membranes from oxidative damage.
What is the recommended dosage of squalene and is it safe?
Oral supplementation typically ranges from 250-1000 mg per day. It is generally well tolerated with few reported side effects. Those on statin medications should consult their physician, as both affect the same metabolic pathway. Plant-derived sources (olive, amaranth) are preferred over shark-derived for both purity and sustainability reasons.
What is the difference between squalene and squalane?
Squalene is the natural, unsaturated form found in living organisms and dietary sources. Squalane is the hydrogenated (saturated) form, which is more stable and resistant to oxidation — making it preferred for topical skincare products. Orally, squalene is the biologically active form. Both are used in different applications depending on stability requirements.
Explore the Full Encyclopedia
7,400+ ingredients researched, verified, and formulated for optimal synergy.
Browse IngredientsThese statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.
