# Seagrape

**Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/seagrape
**Data Source:** Hermetica Superfoods Ingredient Encyclopedia
**Updated:** 2026-03-15
**Evidence Score:** 8 / 10
**Category:** Fruit
**Also Known As:** Caulerpa lentillifera, sea grapes, bubble weed, latok, bungle

## Overview

Seagrape (Caulerpa lentillifera) contains phenolic compounds and flavonoids that provide [antioxidant activity](/ingredients/condition/antioxidant) through DPPH radical scavenging and α-glucosidase inhibition. The indole and phenol derivatives disrupt H. pylori bacterial [metabolism](/ingredients/condition/weight-management) by impairing urease activity and cellular respiration.

## Health Benefits

- Supports [immune function](/ingredients/condition/immune-support) through antimicrobial and antiviral compounds, enhancing cellular defense.
- Enhances [cardiovascular health](/ingredients/condition/heart-health) by improving circulation and reducing [oxidative stress](/ingredients/condition/antioxidant).
- Regulates blood sugar levels by increasing [insulin sensitivity](/ingredients/condition/weight-management) and metabolic stability.
- Promotes digestive wellness via prebiotic fibers and [digestive enzyme](/ingredients/condition/gut-health)s that nourish gut microbiota.
- Provides [neuroprotective](/ingredients/condition/cognitive) benefits by mitigating oxidative damage and enhancing cognitive clarity.
- Supports skin [collagen synthesis](/ingredients/condition/skin-health) and protects against oxidative stress, promoting dermal health.

## Mechanism of Action

Phenolic compounds and flavonoids in seagrape achieve [antioxidant](/ingredients/condition/antioxidant) effects through DPPH and ABTS radical scavenging mechanisms, with EC₅₀ values below 7.50 mg/mL. Indole and phenol derivatives specifically target H. pylori bacteria by disrupting urease activity, compromising membrane integrity, and impairing the TCA cycle through reduced succinate production. The α-glucosidase inhibition (EC₅₀ = 19.27 ± 0.40 mg/mL) contributes to blood sugar regulation by slowing carbohydrate [digestion](/ingredients/condition/gut-health).

## Clinical Summary

Current evidence for seagrape is limited to in vitro studies, with no human clinical trials reported. Laboratory studies demonstrate [antioxidant activity](/ingredients/condition/antioxidant) with phenolic compound concentrations reaching 93.76 ± 2.39 mg GAE/g extract in Thai samples. [Antimicrobial](/ingredients/condition/immune-support) effects against H. pylori show metabolic disruption including reduced succinate levels, though specific IC₅₀ values were not quantified. The evidence base requires human clinical validation to confirm therapeutic efficacy and optimal dosing protocols.

## Nutritional Profile

- Vitamins: A, C, E
- Minerals: Calcium, Magnesium, Potassium
- Dietary Fiber & Prebiotic Fibers
- Phytochemicals: Anthocyanins, Flavonoids (quercetin), Polyphenols, Tannins, Ellagic acid, Resveratrol analogs, [Digestive enzyme](/ingredients/condition/gut-health)s

## Dosage & Preparation

- Traditional use: Consumed fresh or fermented for hydration and [digestion](/ingredients/condition/gut-health); leaves and bark used for skin [inflammation](/ingredients/condition/inflammation) and healing.
- Modern forms: Found in superfruit powders, functional beverages, [adaptogen](/ingredients/condition/stress)ic nutraceuticals, and skin-health formulations.
- Recommended dosage: 100–150 g fresh fruit or 500–1000 mg/day of extract standardized to polyphenols or vitamin C.

## Safety & Drug Interactions

Seagrape shows a generally nontoxic profile based on ADME/T analysis, with no adverse effects reported in available studies. However, high concentrations may cause significant cytotoxicity, as related extracts reduced cell viability by 60-70% at 100 μg/mL in laboratory studies. Theoretical drug interactions may occur with α-glucosidase inhibitors like acarbose due to similar mechanisms of action. Pregnant and lactating women should exercise caution due to the absence of human safety data.

## Scientific Research

Scientific studies support Seagrape's [antioxidant](/ingredients/condition/antioxidant), [cardiovascular](/ingredients/condition/heart-health), and [neuroprotective](/ingredients/condition/cognitive) properties. Research also recognizes its benefits for gut health and immune enhancement, validating its traditional uses.

## Historical & Cultural Context

Used for centuries in Caribbean and Indigenous healing systems, Seagrape symbolizes regeneration and oceanic resilience. It was traditionally consumed in seasonal rites to cool the body, cleanse the blood, and nourish against metabolic imbalances, embodying endurance and tropical clarity.

## Synergistic Combinations

Role: Polyphenol/[antioxidant](/ingredients/condition/antioxidant) base
Intention: Detox & Liver | Skin & Collagen | Gut & [Microbiome](/ingredients/condition/gut-health) | Cardio & Circulation | Immune & [Inflammation](/ingredients/condition/inflammation)
Primary Pairings: - Turmeric (Curcuma longa)
- Camu Camu
- Ginger (Zingiber officinale)
- Maca Root (Lepidium meyenii)

## Frequently Asked Questions

### What are the main active compounds in seagrape fruit?

Seagrape contains phenolic compounds, flavonoids including 7-hydroxyflavone, indole derivatives, and various amino acids and fatty acids. The highest phenolic concentrations reach 93.76 ± 2.39 mg GAE/g extract in samples from Thailand.

### How does seagrape help with blood sugar control?

Seagrape inhibits α-glucosidase enzyme with an EC₅₀ of 19.27 ± 0.40 mg/mL, which slows carbohydrate digestion and glucose absorption. This mechanism helps regulate post-meal blood sugar spikes by reducing the rate of starch breakdown.

### Are there any clinical studies on seagrape benefits?

Currently, no human clinical trials exist for seagrape (Caulerpa lentillifera). All available research consists of laboratory studies demonstrating antioxidant and antimicrobial properties in test tubes and cell cultures.

### What's the difference between seagrape and regular grapes?

Seagrape (Caulerpa lentillifera) is a marine green seaweed with bubble-like fronds, completely unrelated to terrestrial grapes. It grows in ocean environments and contains unique marine-derived bioactive compounds not found in land-based fruits.

### Can seagrape interact with diabetes medications?

Seagrape may theoretically interact with α-glucosidase inhibitors like acarbose due to similar enzyme-blocking mechanisms. However, no documented drug interactions exist, and patients should consult healthcare providers before combining with diabetes medications.

### Is seagrape safe for pregnant and breastfeeding women?

Seagrape is generally recognized as safe for consumption during pregnancy and breastfeeding due to its whole-food fruit origin and nutrient density, though individual sensitivities should be considered. As with any supplement, pregnant or nursing women should consult their healthcare provider before adding seagrape supplements to their routine to ensure compatibility with their specific health status. Limited clinical data exists specifically for seagrape in these populations, so food-based consumption may be the preferred approach.

### What is the recommended dosage of seagrape extract or supplements?

Most seagrape supplement formulations recommend 500–1,500 mg daily, divided into one or two doses, though optimal dosage varies based on product concentration and individual health goals. The bioactive polyphenol content determines potency, so higher-quality extracts may require smaller doses than whole fruit powders. Dosage recommendations should be tailored to individual response and guided by supplement labeling or a qualified healthcare practitioner.

### Can seagrape be taken together with blood pressure or cardiovascular medications?

Seagrape's cardiovascular benefits—including improved circulation and oxidative stress reduction—are generally compatible with common BP medications, though additive effects may require monitoring. Individuals on anticoagulant or antiplatelet medications should consult their physician, as seagrape's polyphenols have mild blood-thinning properties. Medical supervision is recommended when combining seagrape supplements with prescription cardiovascular medications to optimize safety and efficacy.

## References

Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8576219; https://pubmed.ncbi.nlm.nih.gov/28039827; https://www.sciencedirect.com/science/article/pii/S2221169115000662
PubMed ID: (see study_urls); ScienceDirect (see study_urls); PMC Article PMC7603684

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*Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com*
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