# Sanguiin H-6

**Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/sanguiin-h-6
**Data Source:** Hermetica Superfoods Ingredient Encyclopedia
**Updated:** 2026-03-20
**Evidence Score:** 2 / 10
**Category:** Compound
**Also Known As:** Sanguiin H-6, SH-6, Rubus tannin H-6, Hydrolyzable tannin H-6, Raspberry ellagitannin, Sanguisorba tannin H-6

## Overview

Sanguiin H-6 is an ellagitannin compound that inhibits osteoclast formation by blocking nuclear translocation of NFATc1, c-Fos, and [NF-κB](/ingredients/condition/inflammation) transcription factors. This polyphenolic compound demonstrates anti-resorptive effects in bone [metabolism](/ingredients/condition/weight-management) studies.

## Health Benefits

• Inhibits osteoclastogenesis by blocking nuclear translocation of NFATc1, c-Fos, and [NF-κB](/ingredients/condition/inflammation), as shown in in-vitro studies [4]. • Reduces multinucleated osteoclast formation in bone marrow macrophages and RAW-D cells [4]. • Decreases TRAP-positive osteoclasts in cell assays [4]. • Demonstrates potential cytotoxicity above certain concentrations, indicating a need for careful dosage [4]. • Lacks comprehensive human clinical evidence, indicating preliminary findings [4].

## Mechanism of Action

Sanguiin H-6 blocks nuclear translocation of key osteoclastogenic transcription factors including NFATc1, c-Fos, and [NF-κB](/ingredients/condition/inflammation). This inhibition prevents the differentiation of bone marrow macrophages and RAW-D cells into multinucleated osteoclasts. The compound specifically reduces TRAP-positive osteoclast formation, disrupting the bone resorption cascade at the cellular level.

## Clinical Summary

Current evidence for sanguiin H-6 comes exclusively from in-vitro studies examining osteoclast formation. Research has focused on bone marrow macrophages and RAW-D cell cultures, demonstrating significant reduction in multinucleated osteoclast formation and TRAP-positive cell counts. No human clinical trials or animal studies have been published to date. The evidence base remains limited to cellular mechanisms without dosage recommendations or bioavailability data.

## Nutritional Profile

Sanguiin H-6 is not a nutrient but a high-molecular-weight ellagitannin (a type of hydrolyzable polyphenolic tannin) with a molecular formula of C82H54O52 and a molecular weight of approximately 1871 g/mol. It is one of the principal bioactive polyphenolic compounds found in raspberries (Rubus idaeus), strawberries (Fragaria × ananassa), and other Rubus species. Key details: • Classification: Dimeric ellagitannin, formed from two units of casuarictin linked via a dehydrodigalloyl (valoneoyl) group. • Concentration in food sources: Found at concentrations of approximately 172–805 mg/100 g dry weight in red raspberry fruit, making it the dominant ellagitannin in raspberries; also present in strawberry fruit at lower concentrations (roughly 15–80 mg/100 g dry weight depending on cultivar and extraction method). • Bioactive properties: Polyphenolic compound with documented [antioxidant](/ingredients/condition/antioxidant), [anti-inflammatory](/ingredients/condition/inflammation), and anti-osteoclastogenic activities; it is not a source of macronutrients (protein, fat, carbohydrate), vitamins, or minerals. • Bioavailability: Oral bioavailability is considered very low due to its large molecular size and susceptibility to hydrolysis in the gastrointestinal tract. In the gut, sanguiin H-6 is partially hydrolyzed to release ellagic acid, which is further metabolized by colonic microbiota into urolithins (primarily urolithin A and urolithin B), the forms that are actually absorbed systemically. Intact sanguiin H-6 is largely undetectable in plasma after oral consumption. Therefore, its systemic biological effects are believed to be mediated primarily through its gut-derived metabolites (urolithins) rather than the parent compound. • No appreciable caloric, vitamin, mineral, or fiber contribution as an isolated compound. • Solubility: Soluble in aqueous-organic solvent mixtures (e.g., methanol-water, acetone-water); limited solubility in pure water at physiological pH.

## Dosage & Preparation

There are no clinically studied dosage ranges due to the absence of human trials. In vitro studies used 5 μM to 50 μM concentrations, noting cytotoxicity above 25-50 μM. Consult a healthcare provider before starting any new supplement.

## Safety & Drug Interactions

No safety data exists for sanguiin H-6 as human studies have not been conducted. As an ellagitannin, it may theoretically interact with iron absorption and certain medications metabolized by cytochrome P450 enzymes. Pregnancy and lactation safety is unknown due to lack of research. Individuals with bleeding disorders should exercise caution as tannins may affect platelet function.

## Scientific Research

No human clinical trials or meta-analyses are available for Sanguiin H-6. Current research is limited to in-vitro studies focusing on its effects on osteoclastogenesis in cell models [4].

## Historical & Cultural Context

No specific historical or traditional medicinal uses for Sanguiin H-6 are documented in the research. It remains primarily studied in modern scientific contexts.

## Synergistic Combinations

Curcumin, Resveratrol, Quercetin, Omega-3 fatty acids, Vitamin D

## Frequently Asked Questions

### What foods contain sanguiin H-6?

Sanguiin H-6 is found primarily in strawberries and other Rosaceae family fruits. It's also present in pomegranates and certain medicinal plants, though concentrations vary significantly based on cultivar and growing conditions.

### How does sanguiin H-6 affect bone health?

Sanguiin H-6 inhibits osteoclast formation by blocking NFATc1, c-Fos, and NF-κB nuclear translocation. This prevents bone-resorbing cells from developing, potentially supporting bone density maintenance through reduced bone breakdown.

### Is sanguiin H-6 available as a supplement?

Sanguiin H-6 is not commonly available as an isolated supplement. It's typically consumed through strawberry extracts or pomegranate supplements that contain mixed ellagitannins, though specific sanguiin H-6 content is rarely standardized.

### What's the difference between sanguiin H-6 and other ellagitannins?

Sanguiin H-6 has a unique dimeric structure that specifically targets osteoclast transcription factors. Unlike other ellagitannins that focus on antioxidant activity, sanguiin H-6 shows particular selectivity for bone metabolism pathways.

### How much sanguiin H-6 should you take daily?

No established dosage exists for sanguiin H-6 due to lack of human studies. Research has only examined cellular effects in laboratory conditions without determining effective doses or bioavailability in humans.

### What does research show about sanguiin H-6's safety at different dose levels?

In-vitro studies demonstrate that sanguiin H-6 exhibits dose-dependent effects, with potential cytotoxicity observed at higher concentrations, indicating a narrow therapeutic window. This suggests that while the compound shows promise for bone health through osteoclast inhibition, careful dosage optimization is critical to avoid adverse effects. However, human clinical trials establishing safe dosage ranges in populations are currently limited, making supplement use more cautious than food-based consumption.

### Who would benefit most from sanguiin H-6 supplementation based on its mechanism of action?

Individuals at risk for excessive bone resorption—such as those with osteoporosis, postmenopausal women, or those on long-term corticosteroid therapy—may theoretically benefit most from sanguiin H-6 due to its ability to inhibit osteoclastogenesis and reduce bone-degrading cell formation. The compound's mechanism of blocking nuclear translocation of key transcription factors (NFATc1, c-Fos, NF-κB) specifically targets the molecular pathways driving osteoclast development. However, clinical evidence in human populations remains insufficient to make definitive recommendations for supplementation in these groups.

### How does sanguiin H-6 compare to synthetic bone-protective drugs in terms of mechanism?

Sanguiin H-6 operates through natural inhibition of osteoclast formation by blocking intracellular signaling pathways (NFATc1, c-Fos, NF-κB translocation), a mechanism conceptually similar to bisphosphonates and monoclonal antibodies used clinically for osteoporosis. Unlike these drugs, sanguiin H-6 is a plant-derived ellagitannin with a different chemical structure and potential for synergistic effects with other bioactive compounds in foods. Evidence for sanguiin H-6 remains primarily in-vitro, whereas clinical drugs have undergone extensive human trials, making direct efficacy comparisons premature.

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*Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com*
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