# Rosavin **Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/rosavin **Data Source:** Hermetica Superfoods Ingredient Encyclopedia **Updated:** 2026-03-30 **Evidence Score:** 2 / 10 **Category:** Compound **Also Known As:** Rhodiola rosavin, Golden Root extract compound, Arctic Root phenylpropanol, Rose root glycoside, Rhodiola rosea rosavin, Phenylpropanol glycoside from Rhodiola, Rosavin glycoside ## Overview Rosavin is a phenylpropanoid glycoside derived from Rhodiola rosea that acts as a potent antioxidant by inhibiting [reactive oxygen species](/ingredients/condition/antioxidant) formation. This bioactive compound demonstrates lipid-lowering effects and analgesic properties through its modulation of oxidative stress pathways. ## Health Benefits • Antioxidant activity: Rosavin inhibits [reactive oxygen species](/ingredients/condition/antioxidant), providing significant antioxidant effects in preclinical models.[1] • Lipid-lowering effects: Studies demonstrate its potential to lower lipid levels in animal models, suggesting benefits for [cardiovascular health](/ingredients/condition/heart-health).[1] • Analgesic properties: In vitro and in vivo studies show Rosavin's ability to reduce pain perception.[1][2] • Antitumor activity: Preclinical research indicates Rosavin may inhibit tumor growth, though human studies are lacking.[1] • [Immunomodulatory](/ingredients/condition/immune-support) effects: Evidence from animal studies points to Rosavin's potential to modulate immune responses.[1] ## Mechanism of Action Rosavin exerts its antioxidant effects by scavenging [reactive oxygen species](/ingredients/condition/antioxidant) (ROS) and inhibiting lipid peroxidation through modulation of antioxidant enzyme systems including superoxide dismutase and catalase. The compound influences lipid [metabolism](/ingredients/condition/weight-management) by regulating HMG-CoA reductase activity and enhancing cholesterol excretion pathways. Its analgesic properties appear to involve modulation of [inflammatory](/ingredients/condition/inflammation) mediators and nociceptive pathways. ## Clinical Summary Current evidence for rosavin is primarily limited to preclinical animal studies and in vitro research. Animal studies have demonstrated significant [antioxidant activity](/ingredients/condition/antioxidant) with measurable reductions in oxidative stress markers. Lipid-lowering effects have been observed in rodent models with reported decreases in total cholesterol and triglyceride levels. Human clinical trials specifically investigating isolated rosavin are lacking, limiting the strength of evidence for therapeutic applications in humans. ## Nutritional Profile Rosavin is a phenylpropanoid glycoside compound (molecular formula C20H28O10, molecular weight 428.43 g/mol), not a whole food ingredient and therefore does not contain conventional macronutrients, micronutrients, fiber, or protein. As a pure bioactive compound, its profile is defined entirely by its chemical structure and pharmacological activity. Rosavin is one of the primary marker compounds found in Rhodiola rosea root, where it occurs at concentrations of approximately 0.8–3% by dry weight in standardized extracts, with commercial extracts typically standardized to a minimum of 3% rosavin content. It belongs to the cinnamyl alcohol glycoside subclass, consisting of a cinnamyl alcohol aglycone linked to a trisaccharide unit (glucose, arabinose, and rhamnose). Structurally related compounds present alongside rosavin in its natural source include rosin and rosarin, which share the same glycoside backbone but differ in sugar moiety composition. Bioavailability data is limited in humans; preclinical studies suggest rosavin undergoes hydrolysis in the gastrointestinal tract, releasing the cinnamyl alcohol aglycone, which is believed to be the primary bioactive moiety absorbed. Oral bioavailability is considered moderate, with enzymatic degradation by gut microbiota potentially influencing active metabolite availability. No caloric, vitamin, or mineral content is attributable to rosavin as an isolated compound. ## Dosage & Preparation There are no clinically studied dosage ranges or forms for Rosavin due to the absence of human trials. Consult a healthcare provider before starting any new supplement. ## Safety & Drug Interactions Safety data for isolated rosavin is limited, with most information derived from Rhodiola rosea studies containing multiple active compounds. No major adverse effects have been reported in preclinical studies at standard dosages. Potential interactions with [cardiovascular](/ingredients/condition/heart-health) medications and blood thinners should be considered due to its lipid-lowering and [antioxidant](/ingredients/condition/antioxidant) properties. Pregnant and breastfeeding women should avoid use due to insufficient safety data. ## Scientific Research No specific human clinical trials or meta-analyses for Rosavin are available. The evidence is limited to in vitro and in vivo studies demonstrating various pharmacological effects.[1][2] ## Historical & Cultural Context Rhodiola rosea L., the source of Rosavin, has been used in traditional medicine, particularly noted for its antifatigue and antistress effects observed by Russian botanists. These traditional uses highlight its value in herbal medicine practices. ## Synergistic Combinations Salidroside, Tyrosol, Flavonoids, Tannins ## Frequently Asked Questions ### What is rosavin and where does it come from? Rosavin is a phenylpropanoid glycoside found primarily in Rhodiola rosea root. It is one of the three main rosavins (rosavin, rosin, and rosarin) that characterize authentic Rhodiola rosea extracts. ### How much rosavin should I take daily? There is no established dosage for isolated rosavin due to limited human studies. Rhodiola rosea extracts typically contain 1-3% rosavin, with effective extract doses ranging from 200-600mg daily. ### Can rosavin help lower cholesterol levels? Animal studies suggest rosavin may help reduce cholesterol and triglyceride levels through modulation of lipid metabolism enzymes. However, human clinical trials are needed to confirm these lipid-lowering effects. ### Is rosavin safe to take with blood pressure medications? Rosavin may have cardiovascular effects that could potentially interact with blood pressure medications. Consult with a healthcare provider before combining rosavin supplements with any cardiovascular drugs. ### How long does it take for rosavin to show antioxidant effects? Preclinical studies show rosavin's antioxidant activity occurs relatively quickly at the cellular level. However, the timeline for measurable health benefits in humans remains unclear due to limited clinical research. ### Does rosavin have any interactions with pain medications or NSAIDs? Rosavin possesses analgesic properties that may complement pain management, but combining it with prescription pain medications or NSAIDs should be discussed with a healthcare provider to avoid potential additive effects or unexpected interactions. While preclinical studies show rosavin's pain-reducing abilities, clinical data on concurrent use with common analgesics remains limited. Your physician can assess whether rosavin is appropriate alongside your current pain management regimen. ### Is rosavin more effective in extract form or as a standalone compound? Rosavin is typically derived from Rhodiola rosea root extract, where it exists alongside other bioactive compounds that may work synergistically to enhance overall efficacy. Isolated rosavin supplements are less common than standardized Rhodiola extracts containing multiple active constituents. Clinical evidence suggests that Rhodiola extracts with multiple compounds, including rosavin, may provide broader benefits than rosavin alone, though direct comparative studies are limited. ### Who is most likely to benefit from rosavin supplementation? Individuals seeking antioxidant support or those interested in natural approaches to cardiovascular health and pain management may be candidates for rosavin supplementation, particularly those unable to obtain sufficient amounts from Rhodiola rosea sources. People with oxidative stress-related concerns or those looking to complement conventional treatments may also benefit, though personalized medical guidance is recommended. Rosavin may be less suitable for pregnant or nursing women, and those on anticoagulants should consult a healthcare provider before use. --- *Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com* *License: CC BY-NC-SA 4.0 — Attribution required. Commercial use: admin@hermeticasuperfoods.com*