# Rosa rugosa

**Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/rosa-rugosa
**Data Source:** Hermetica Superfoods Ingredient Encyclopedia
**Updated:** 2026-04-02
**Evidence Score:** 2 / 10
**Category:** European
**Also Known As:** rugosa rose, Japanese rose, beach rose, ramanas rose, Turkestan rose, sea tomato, beach tomato, salt spray rose, wrinkled rose, hedgehog rose

## Overview

Rosa rugosa is a flowering plant whose petals and hips are rich in polyphenols including quercetin, kaempferol, and ellagic acid. These compounds inhibit pro-inflammatory enzymes and signaling pathways, contributing to [antioxidant](/ingredients/condition/antioxidant) and [anti-inflammatory](/ingredients/condition/inflammation) activity documented in preclinical models.

## Health Benefits

• [Anti-inflammatory](/ingredients/condition/inflammation) effects: Flower extract reduced inflammatory markers (NO by 76%, PGE2 by 43%) and cytokines in macrophage studies (preliminary evidence)
• [Hair growth](/ingredients/condition/skin-health) promotion: Oral water extract promoted hair regrowth and increased follicle number/size in mouse models (preliminary evidence)
• [Immune system](/ingredients/condition/immune-support) modulation: Polysaccharide extracts enhanced lymphocyte proliferation and macrophage activity in vitro (preliminary evidence)
• [Neuroprotective](/ingredients/condition/cognitive) potential: Root extracts contain oleamide compound with reported neuroprotective properties (preliminary evidence)
• Stress relief support: Traditional use for stress relief demonstrated in animal endurance models (traditional evidence)

## Mechanism of Action

Rosa rugosa polyphenols, particularly quercetin and kaempferol, suppress NF-κB signaling and inhibit cyclooxygenase (COX) and inducible nitric oxide synthase (iNOS) enzymes, reducing downstream production of nitric oxide (NO) and [prostaglandin](/ingredients/condition/inflammation) E2 (PGE2). Ellagic acid and gallic acid derivatives further scavenge [reactive oxygen species](/ingredients/condition/antioxidant) and modulate MAPK pathways to attenuate cytokine release from activated macrophages. In hair follicle models, the water extract is hypothesized to stimulate dermal papilla proliferation, possibly via Wnt/β-catenin pathway activation, though the precise molecular target remains unconfirmed.

## Clinical Summary

Current evidence for Rosa rugosa is limited to in vitro and animal studies with no published randomized controlled trials in humans identified to date. In macrophage cell culture studies, flower extract reduced nitric oxide production by approximately 76% and PGE2 by 43%, indicating meaningful [anti-inflammatory](/ingredients/condition/inflammation) activity under controlled laboratory conditions. A mouse model of hair regrowth demonstrated that oral administration of aqueous Rosa rugosa extract promoted hair follicle regeneration and increased both follicle number and follicle size compared to controls. These findings are considered preliminary and require replication in human clinical trials before efficacy claims can be substantiated.

## Nutritional Profile

Rosa rugosa petals and hips are nutritionally distinct components. Rose hips are among the richest plant sources of Vitamin C (ascorbic acid), containing approximately 400–7,000 mg/100g dry weight depending on ripeness and processing (significantly higher than citrus fruits). Key nutritional components include: Vitamin C (ascorbic acid): 400–7,000 mg/100g dry weight in hips; Vitamin A precursors (beta-carotene): ~3.0–5.0 mg/100g in hips; Vitamin E (tocopherols): ~5–25 mg/100g in hip seed oil; Vitamin K: present in moderate amounts (~25 µg/100g); Dietary fiber: 24–35 g/100g dry weight (hips), comprising both soluble (pectin) and insoluble fractions; Total polyphenols: 800–1,200 mg GAE/100g dry weight in petals, lower in hips (~200–400 mg GAE/100g); Flavonoids: quercetin (15–30 mg/100g), kaempferol, isorhamnetin, rutin; Anthocyanins: cyanidin-3-glucoside and cyanidin-3-rutinoside (~50–150 mg/100g in petals); Ellagitannins and gallotannins: present in hips and leaves (10–50 mg/100g); Carotenoids: lycopene, rubixanthin, beta-carotene collectively ~20–30 mg/100g in ripe hips; Polysaccharides: heteropolysaccharides (arabinogalactans, rhamnogalacturonans) with demonstrated [immunomodulatory](/ingredients/condition/immune-support) activity; Rose hip seed oil contains fatty acids including linoleic acid (omega-6, ~44%), alpha-linolenic acid (omega-3, ~33%), and oleic acid (~15%), plus trans-retinoic acid (~0.01–0.05%); Minerals: potassium (~430 mg/100g dry), calcium (~270 mg/100g), magnesium (~70 mg/100g), iron (~3–11 mg/100g), manganese, zinc; Protein content is modest (~3–6 g/100g dry weight in hips); Bioavailability notes: Vitamin C bioavailability is reduced significantly by drying and heat processing (losses of 30–80%); co-present bioflavonoids (quercetin, rutin) may enhance Vitamin C absorption and stability; carotenoid bioavailability is enhanced by fat co-consumption; polysaccharide immunomodulatory effects are associated with high molecular weight fractions that resist gastric [digestion](/ingredients/condition/gut-health), acting partly via gut microbiota interaction.

## Dosage & Preparation

No clinically studied human dosages available. Preclinical studies used: flower extract 10-100 μg/mL in vitro for [anti-inflammatory](/ingredients/condition/inflammation) effects; oral water extract 25-100 mg/kg body weight daily in mice for 23 days for [hair growth](/ingredients/condition/skin-health). No standardization specified. Consult a healthcare provider before starting any new supplement.

## Safety & Drug Interactions

Rosa rugosa is generally regarded as safe when consumed in food-level quantities such as rose hip teas and culinary preparations, with no serious adverse events reported in traditional use contexts. High-dose concentrated extracts have not been evaluated in formal human safety trials, so the tolerability profile at supplemental doses remains uncertain. Theoretical interactions exist with anticoagulant drugs such as warfarin due to the high vitamin C content in rose hips, which may affect drug [metabolism](/ingredients/condition/weight-management); individuals on blood thinners should consult a physician before supplementing. Pregnancy and lactation safety at supplemental doses has not been established, and use beyond culinary amounts is not recommended during these periods.

## Scientific Research

No human clinical trials, RCTs, or meta-analyses were identified for Rosa rugosa. All current evidence is limited to preclinical in vitro studies using murine macrophages and animal models including C57BL/6 mice for [hair growth](/ingredients/condition/skin-health) (n=~10/group) and stress-related assays.

## Historical & Cultural Context

Rosa rugosa has historical use in Traditional Chinese Medicine (TCM) and Korean folk medicine as an edible plant for [anti-inflammatory](/ingredients/condition/inflammation), [antioxidant](/ingredients/condition/antioxidant), and tonic purposes. It is traditionally consumed as tea or extracts for stress relief and endurance enhancement.

## Synergistic Combinations

Green tea extract, Turmeric, Ginger, Vitamin C, Zinc

## Frequently Asked Questions

### What are the active compounds in Rosa rugosa responsible for its anti-inflammatory effects?

The primary bioactive compounds are polyphenols including quercetin, kaempferol, ellagic acid, and gallic acid derivatives. These molecules inhibit iNOS and COX enzymes, reducing the production of inflammatory mediators NO and PGE2 in macrophage studies by 76% and 43% respectively. Rose hips also contribute significant vitamin C, which supports antioxidant activity.

### Can Rosa rugosa promote hair growth in humans?

Currently, evidence for hair growth promotion is restricted to a mouse model in which oral administration of a water extract increased hair follicle number and follicle size during regrowth phases. No human clinical trials have confirmed this effect, so it is premature to recommend Rosa rugosa specifically for hair loss treatment in people. The proposed mechanism involves stimulation of dermal papilla cells, possibly through Wnt/β-catenin signaling.

### How does Rosa rugosa differ from other rose species used in supplements?

Rosa rugosa, also called the Japanese or Rugosa rose, is distinguished by its exceptionally high hip polyphenol content and elevated vitamin C levels compared to species like Rosa canina commonly used in commercial rose hip products. Its flower petals also contain a distinct aromatic polyphenol profile including specific flavonoids and anthocyanins not uniformly present in other cultivated roses. These compositional differences mean that research findings from one species cannot automatically be applied to another.

### What is the typical dosage of Rosa rugosa extract used in studies?

Published preclinical studies have not established a standardized human-equivalent dosage, as research to date has been conducted in cell cultures and rodent models without dose-escalation trials in humans. Mouse hair regrowth studies administered oral aqueous extracts, but the exact mg/kg dosages used are not uniformly reported across literature. Until human pharmacokinetic and dose-finding trials are completed, no evidence-based supplemental dosage recommendation can be made.

### Is Rosa rugosa safe to take alongside anti-inflammatory medications like ibuprofen?

No controlled interaction studies between Rosa rugosa extracts and NSAIDs such as ibuprofen have been conducted in humans. Because both Rosa rugosa polyphenols and NSAIDs inhibit COX enzymes, concurrent use theoretically risks additive effects on platelet function and gastrointestinal mucosa. Individuals taking prescription anti-inflammatory or anticoagulant medications should consult a healthcare provider before adding Rosa rugosa supplements to their regimen.

### Is Rosa rugosa safe to use during pregnancy and breastfeeding?

There is insufficient clinical evidence regarding the safety of Rosa rugosa supplementation during pregnancy and breastfeeding, so it is generally recommended to avoid use during these periods as a precaution. Pregnant and nursing women should consult with a healthcare provider before using Rosa rugosa products, as the safety profile in these populations has not been adequately established in human studies.

### What is the most effective form of Rosa rugosa for immune system support—extract, powder, or tea?

Polysaccharide-rich extracts of Rosa rugosa have demonstrated the strongest immune-modulating effects in research, showing enhanced lymphocyte proliferation and macrophage activation compared to other forms. While powders and teas may contain beneficial compounds, standardized extracts typically provide more concentrated and consistent polysaccharide content for immune support purposes.

### How strong is the current clinical evidence supporting Rosa rugosa's health benefits in humans?

Most evidence for Rosa rugosa comes from preliminary in vitro and animal studies, particularly regarding anti-inflammatory effects (which reduced NO by 76% and PGE2 by 43% in macrophage models) and hair growth promotion in mouse models. Human clinical trials are limited, so current evidence should be considered preliminary and more robust human studies are needed to confirm efficacy and optimal dosing in people.

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*Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com*
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