# Rhodionin **Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/rhodionin **Data Source:** Hermetica Superfoods Ingredient Encyclopedia **Updated:** 2026-03-20 **Evidence Score:** 2 / 10 **Category:** Compound **Also Known As:** Rhodionin glycoside, Rhodiola flavonoid, Crenulatin, Sachalin rhodioside, Arctic root flavonoid, Golden root glycoside, Hong Jing Tian flavonoid ## Overview Rhodionin is a flavonoid compound primarily found in Rhodiola species that demonstrates potent [antioxidant activity](/ingredients/condition/antioxidant) with an IC50 of 19.49 μM against DPPH radicals. It suppresses postprandial triglyceride elevation and inhibits CYP2D6 enzyme activity, indicating potential metabolic and drug interaction effects. ## Health Benefits • Exhibits antioxidant activity, evidenced by DPPH [free radical scaveng](/ingredients/condition/antioxidant)ing (IC50 19.49 ± 0.21 μM). • Suppresses postprandial blood triglyceride elevation in animal models, suggesting potential for hyperlipidemia. • Non-competitive inhibition of CYP2D6, which may impact drug [metabolism](/ingredients/condition/weight-management). • Potential interactions with drugs metabolized by CYP2D6, such as certain antidepressants. • General antioxidant properties noted, though specific human health benefits are unverified. ## Mechanism of Action Rhodionin exerts antioxidant effects through direct [free radical scaveng](/ingredients/condition/antioxidant)ing, particularly targeting DPPH radicals with an IC50 of 19.49 ± 0.21 μM. The compound demonstrates non-competitive inhibition of cytochrome P450 2D6 (CYP2D6), which plays a crucial role in drug [metabolism](/ingredients/condition/weight-management). Its triglyceride-lowering effects appear to involve suppression of postprandial lipid elevation, though the exact molecular pathway remains under investigation. ## Clinical Summary Current research on rhodionin is primarily based on in vitro antioxidant assays and animal models for lipid [metabolism](/ingredients/condition/weight-management). The [antioxidant activity](/ingredients/condition/antioxidant) has been quantified using DPPH radical scavenging assays, showing moderate potency compared to other flavonoids. Animal studies have demonstrated its ability to suppress postprandial triglyceride elevation, but no human clinical trials have been published to date. The evidence for therapeutic benefits remains preliminary and requires further clinical validation. ## Nutritional Profile Rhodionin is a flavonoid glycoside (specifically a flavonol glycoside) compound, not a macronutrient source. It is not a meaningful contributor of calories, protein, fat, carbohydrates, vitamins, or dietary minerals in typical exposure amounts. Bioactive profile: Rhodionin is the primary bioactive identity itself, classified as a glycosylated flavonol. It demonstrates potent [free radical scaveng](/ingredients/condition/antioxidant)ing activity with a measured DPPH IC50 of 19.49 ± 0.21 μM, indicating strong antioxidant capacity at micromolar concentrations. As a glycoside, its aglycone backbone confers the core antioxidant and enzyme-inhibitory activity. Bioavailability notes: Like most flavonoid glycosides, intestinal absorption is influenced by gut microbial hydrolysis of the sugar moiety prior to or during absorption; the aglycone form may be more readily absorbed across intestinal epithelium. Hepatic first-pass [metabolism](/ingredients/condition/weight-management) is likely relevant given its demonstrated CYP2D6 inhibitory activity (non-competitive inhibition), suggesting it reaches systemic circulation in pharmacologically active concentrations. No established dietary reference intake exists. Fiber, protein, and mineral content are not applicable as this is an isolated phytochemical compound rather than a whole food ingredient. Concentration in source plants (e.g., Rhodiola species) is typically in the low mg/g dry weight range. ## Dosage & Preparation No clinically studied dosage ranges for rhodionin in humans are available. Preclinical assays have used concentrations like IC50 0.761 μM for CYP2D6 inhibition, but no standardization or human dosing is specified. Consult a healthcare provider before starting any new supplement. ## Safety & Drug Interactions Rhodionin's non-competitive inhibition of CYP2D6 suggests potential for drug-drug interactions with medications metabolized by this enzyme, including certain antidepressants, antipsychotics, and beta-blockers. No specific adverse effects have been reported in available studies, but safety data is limited due to lack of human trials. Pregnant and breastfeeding women should avoid rhodionin supplementation due to insufficient safety data. Individuals taking CYP2D6-metabolized medications should consult healthcare providers before use. ## Scientific Research No human clinical trials or meta-analyses on rhodionin have been found. The data available is limited to preclinical in vitro and in vivo studies, with no human validation. No PubMed PMIDs are provided for clinical studies on rhodionin. ## Historical & Cultural Context Rhodionin itself does not have documented traditional or historical medicinal uses. It is found in Rhodiola species, which have been used in Tibetan and Chinese medicine for conditions like fatigue and altitude sickness, but these uses are not attributed directly to rhodionin. ## Synergistic Combinations Rhodiola rosea, Ashwagandha, Ginseng, Turmeric, Green Tea Extract ## Frequently Asked Questions ### What is the IC50 value of rhodionin for antioxidant activity? Rhodionin demonstrates antioxidant activity with an IC50 of 19.49 ± 0.21 μM against DPPH free radicals. This indicates moderate antioxidant potency compared to other flavonoid compounds. ### Does rhodionin interact with prescription medications? Yes, rhodionin exhibits non-competitive inhibition of CYP2D6, a major drug-metabolizing enzyme. This interaction could potentially affect the metabolism of medications like certain antidepressants, antipsychotics, and cardiovascular drugs. ### Can rhodionin help lower triglycerides? Animal studies suggest rhodionin may suppress postprandial blood triglyceride elevation, indicating potential benefits for hyperlipidemia. However, no human clinical trials have confirmed these effects in people. ### What plant sources contain rhodionin? Rhodionin is primarily found in Rhodiola species, particularly Rhodiola rosea. It belongs to the flavonoid class of compounds and contributes to the bioactive profile of these adaptogenic herbs. ### Is rhodionin safe for long-term use? Safety data for long-term rhodionin use is currently insufficient due to lack of human clinical trials. Given its CYP2D6 inhibitory effects, medical supervision is recommended, especially for those taking multiple medications. ### What is the typical dosage range for rhodionin supplements? Clinical dosage information for rhodionin is limited due to its emerging status as a supplement ingredient. Most animal studies have used doses ranging from 10–100 mg/kg body weight, but human equivalent doses have not been firmly established. Consumers should follow manufacturer recommendations on product labels and consult healthcare providers before starting supplementation, as optimal dosing for humans requires further clinical research. ### Who should avoid taking rhodionin due to CYP2D6 interactions? Individuals taking medications metabolized by CYP2D6—such as certain antidepressants (SSRIs), beta-blockers, and antiarrhythmics—should exercise caution with rhodionin, as it is a non-competitive CYP2D6 inhibitor that may alter drug metabolism. Pregnant women and nursing mothers should avoid rhodionin unless cleared by a healthcare provider, as safety data in these populations is unavailable. Patients with liver impairment or those on multiple medications should consult their doctor before use. ### What does current research reveal about rhodionin's antioxidant effectiveness in humans? While rhodionin demonstrates strong antioxidant capacity in laboratory settings (DPPH IC50 of 19.49 ± 0.21 μM) and shows triglyceride-lowering effects in animal models, clinical trials in human subjects remain limited. Most evidence comes from in vitro and animal studies, which cannot be directly extrapolated to human efficacy and safety. Additional well-designed human clinical trials are needed to confirm rhodionin's therapeutic benefits and establish its effectiveness compared to other established antioxidants. --- *Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com* *License: CC BY-NC-SA 4.0 — Attribution required. Commercial use: admin@hermeticasuperfoods.com*