# Resveravine (Vitis vinifera)

**Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/resveravine
**Data Source:** Hermetica Superfoods Ingredient Encyclopedia
**Updated:** 2026-03-29
**Evidence Score:** 2 / 10
**Category:** Other
**Also Known As:** Vitis vinifera stem extract, Grapevine stem extract, Standardized resveratrol extract, Stilbene-rich grapevine extract, Vitis vinifera stilbene extract

## Overview

Resveravine is a proprietary Vitis vinifera (grape vine) extract standardized for stilbene compounds, including resveratrol and related polyphenols, which are theorized to support [cardiovascular health](/ingredients/condition/heart-health) through [antioxidant](/ingredients/condition/antioxidant) and [anti-inflammatory](/ingredients/condition/inflammation) mechanisms. However, no human clinical trials have been conducted specifically on the Resveravine extract itself, meaning its efficacy and optimal dosage in humans remain unestablished.

## Health Benefits

• No clinical evidence available - potential [cardiovascular](/ingredients/condition/heart-health) benefits based only on general resveratrol research, not this specific extract
• No human trials conducted - [antioxidant](/ingredients/condition/antioxidant) properties theorized from stilbene content but unproven for Resveravine
• No RCTs identified - [anti-inflammatory](/ingredients/condition/inflammation) effects possible via NF-κB pathways but lacking clinical validation
• No meta-analyses found - SIRT1 activation potential based on resveratrol mechanism, not studied for this extract
• No safety data established - drug interaction risks with anticoagulants like warfarin via CYP enzyme inhibition remain theoretical

## Mechanism of Action

Resveravine's proposed mechanisms are extrapolated from resveratrol research, where the stilbene compound activates SIRT1 ([sirtuin](/ingredients/condition/longevity)-1) deacetylase and AMP-activated protein kinase (AMPK), pathways linked to cellular energy regulation and [endothelial function](/ingredients/condition/heart-health). Resveratrol-class stilbenes also inhibit cyclooxygenase (COX-1 and COX-2) enzymes and suppress NF-κB signaling, which may reduce [pro-inflammatory cytokine](/ingredients/condition/inflammation) production including TNF-α and IL-6. Additionally, these compounds are theorized to upregulate endothelial nitric oxide synthase (eNOS), potentially improving vasodilation, though none of these pathways have been confirmed specifically for the Resveravine formulation in human tissue.

## Clinical Summary

No randomized controlled trials, observational studies, or human pharmacokinetic studies have been published specifically investigating the Resveravine extract. Existing cardiovascular evidence is borrowed from broader resveratrol research, including small RCTs (typically 20–100 participants) examining isolated trans-resveratrol at doses of 150–1000 mg/day, which have shown modest reductions in systolic [blood pressure](/ingredients/condition/heart-health) and LDL oxidation in some studies. The bioavailability and stilbene profile of Resveravine may differ from isolated resveratrol, making direct extrapolation scientifically unreliable. Until dedicated clinical trials are conducted, any cardiovascular benefit claims for Resveravine specifically remain speculative.

## Nutritional Profile

Resveravine is a proprietary or specialized extract derived from Vitis vinifera (grapevine), typically sourced from vine shoots, canes, or root tissues rather than fruit or seeds. It is not a conventional nutritional supplement and lacks a standard macronutrient profile (negligible protein, fat, carbohydrate, and fiber content as it is consumed as a concentrated extract, not a whole food). Key bioactive compounds include: • trans-Resveratrol (3,5,4'-trihydroxystilbene): the principal stilbenoid, typically standardized in vine-derived extracts to approximately 5–20% by weight depending on extraction method and plant part; bioavailability is notably low (<1–5% of oral dose reaches systemic circulation unchanged) due to rapid Phase II [metabolism](/ingredients/condition/weight-management) (glucuronidation and sulfation in intestinal epithelium and liver). • Viniferin (ε-viniferin and δ-viniferin): resveratrol dimers/oligomers present in Vitis vinifera woody tissues at variable concentrations (estimated 0.5–5% of extract); ε-viniferin may have greater metabolic stability than resveratrol monomer but human pharmacokinetic data are essentially absent. • Piceatannol (3,3',4,5'-tetrahydroxystilbene): a hydroxylated resveratrol analog found at lower concentrations (~0.1–2%); it is also a metabolite of resveratrol via CYP1B1; may exhibit marginally better absorption than resveratrol in some preclinical models. • Additional stilbenoid oligomers (e.g., hopeaphenol, miyabenol C, ampelopsin A): trace to minor concentrations depending on source tissue (vine shoots vs. roots); biological significance in humans is unknown. • Polyphenolic matrix compounds: minor amounts of catechins, epicatechins, procyanidins, and phenolic acids (gallic acid, caffeic acid) may co-extract but at much lower levels than in grape seed or skin extracts. • Micronutrients: no significant vitamin or mineral content expected from a concentrated stilbene extract; any mineral content (potassium, calcium, magnesium) would be negligible per serving dose. • Typical serving/dose: not standardized; experimental or commercial doses of vine-shoot stilbene extracts range from 100–500 mg of total extract per day, delivering roughly 10–100 mg of combined stilbenoids. • Bioavailability notes: The stilbene backbone undergoes extensive first-pass metabolism; plasma half-life of free resveratrol is approximately 1–3 hours. Conjugated metabolites (resveratrol-3-O-sulfate, resveratrol-3-O-glucuronide) predominate in circulation and may retain partial biological activity, though this remains debated. Co-administration with dietary fats or piperine has been suggested to modestly enhance absorption in preclinical studies but is unvalidated for Resveravine specifically. The oligomeric stilbenoids (viniferins) have higher molecular weight and potentially different absorption kinetics, but no human pharmacokinetic studies exist for these compounds from this specific extract source.

## Dosage & Preparation

No clinically studied dosages exist for Resveravine. Analytical yields show standardized extracts contain 11-28% resveratrol and 10-12% ε-viniferin, but these are not therapeutic dose recommendations. Consult a healthcare provider before starting any new supplement.

## Safety & Drug Interactions

Because no dedicated human safety trials exist for Resveravine, its side effect profile is inferred from resveratrol studies, where gastrointestinal symptoms such as nausea, diarrhea, and abdominal discomfort have been reported at doses above 1000 mg/day. Resveratrol-class stilbenes may inhibit CYP3A4 and CYP2C9 liver enzymes, raising the risk of interactions with anticoagulants such as warfarin, antiplatelet drugs like aspirin or clopidogrel, and certain statins. Due to weak estrogenic activity at the ER-β receptor, Resveravine should be used with caution by individuals with hormone-sensitive conditions. Pregnant and breastfeeding women should avoid this supplement entirely given the complete absence of safety data for this specific extract in those populations.

## Scientific Research

No human clinical trials, RCTs, or meta-analyses were identified for Resveravine or equivalent Vitis vinifera stem extracts standardized for resveratrol/ε-viniferin. Available research focuses solely on extraction optimization methods without any clinical efficacy or safety data.

## Historical & Cultural Context

No traditional medicine use is documented for Resveravine or grapevine stem extracts in the available sources. While resveratrol occurs naturally in grape skins and seeds during wine production, stems and branches lack referenced traditional applications in systems like Ayurveda or Traditional Chinese Medicine.

## Synergistic Combinations

Quercetin, Grape Seed Extract, Pine Bark Extract, Green Tea Extract, Turmeric

## Frequently Asked Questions

### What is Resveravine and how is it different from regular resveratrol?

Resveravine is a proprietary extract derived from Vitis vinifera (grapevine) standardized to contain a spectrum of stilbene compounds, whereas regular resveratrol supplements typically contain isolated trans-resveratrol. The full stilbene profile of Resveravine, including potential compounds like viniferin or piceatannol alongside resveratrol, may differ in bioavailability and activity, but no comparative pharmacokinetic studies have been published to confirm whether Resveravine performs better or worse than isolated resveratrol in humans.

### Is there any clinical evidence that Resveravine supports heart health?

There are currently no published clinical trials—including no RCTs, pilot studies, or human observational data—specifically evaluating Resveravine for heart health outcomes. Any cardiovascular claims are theoretical, based on extrapolation from general resveratrol research showing modest effects on LDL oxidation, blood pressure, and endothelial function in small human trials. Consumers should treat Resveravine's cardiovascular benefits as unproven until dedicated human studies are conducted.

### What is the recommended dosage of Resveravine?

No clinically established dosage exists for Resveravine because human dose-ranging or pharmacokinetic studies have not been published for this specific extract. Product manufacturers typically suggest doses between 100–500 mg/day, often based on analogous resveratrol research where 150–500 mg/day of trans-resveratrol has been used in cardiovascular studies. Without Resveravine-specific trial data, these dosage recommendations lack an evidence-based foundation.

### Can Resveravine interact with blood thinners or medications?

Based on resveratrol pharmacology, Resveravine may inhibit cytochrome P450 enzymes CYP3A4 and CYP2C9, which are responsible for metabolizing anticoagulants like warfarin, increasing plasma drug levels and bleeding risk. It may also potentiate the antiplatelet effects of aspirin and clopidogrel by inhibiting thromboxane A2 synthesis. Anyone taking anticoagulant, antiplatelet, or cardiovascular medications should consult a physician before using Resveravine.

### Is Resveravine safe to take during pregnancy?

Resveravine should not be taken during pregnancy or breastfeeding due to a complete absence of safety data for this specific extract in those populations. General resveratrol research in animal models has raised concerns about interference with estrogen receptor signaling and potential effects on fetal development at high doses. Until human safety data specific to Resveravine is available, pregnant and nursing women should avoid this supplement entirely.

### What is the bioavailability of Resveravine compared to standard resveratrol supplements?

Resveravine is a branded extract from Vitis vinifera designed to enhance bioavailability through its proprietary formulation, though specific absorption data comparing it directly to standard resveratrol is not publicly available. The extract's theoretical advantage lies in its stilbene profile and concentration, but clinical studies measuring actual bioavailability in humans have not been conducted. Without peer-reviewed pharmacokinetic data, claims about superior absorption remain largely based on the manufacturer's formulation design rather than validated clinical evidence.

### Who should consider taking Resveravine, and are there specific populations that should avoid it?

Resveravine may appeal to individuals interested in antioxidant support based on general resveratrol research, though no clinical trials have identified specific populations most likely to benefit from this branded ingredient. People taking anticoagulants, those with bleeding disorders, or individuals preparing for surgery should consult a healthcare provider due to resveratrol's potential blood-thinning properties. Because human safety and efficacy data for Resveravine specifically are absent, it is not recommended for children or nursing mothers without medical guidance.

### What does the current scientific evidence show about Resveravine's effectiveness compared to the general resveratrol research?

No human clinical trials or randomized controlled trials exist specifically testing Resveravine, so its efficacy cannot be claimed based on direct clinical evidence. While general resveratrol research suggests potential benefits through SIRT1 activation and NF-κB pathway modulation, these mechanisms have not been validated for this specific branded extract. Any health claims about Resveravine must be distinguished from the broader resveratrol literature, as the branded ingredient's actual effects remain unproven in human subjects.

---

*Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com*
*License: CC BY-NC-SA 4.0 — Attribution required. Commercial use: admin@hermeticasuperfoods.com*