# Resveratrol (Stilbene)

**Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/resveratrol
**Data Source:** Hermetica Superfoods Ingredient Encyclopedia
**Updated:** 2026-03-19
**Evidence Score:** 8 / 10
**Category:** Compound
**Also Known As:** trans-3,4',5-trihydroxystilbene, 3,5,4'-trihydroxy-trans-stilbene, stilbenoid, phytoalexin, grape polyphenol, red wine extract compound, trans-resveratrol

## Overview

Resveratrol is a stilbenoid compound found in grape skins and red wine that activates SIRT1 proteins and provides [antioxidant activity](/ingredients/condition/antioxidant). This polyphenol modulates [inflammatory pathway](/ingredients/condition/inflammation)s and may support [cardiovascular health](/ingredients/condition/heart-health) through its effects on endothelial function.

## Health Benefits

• [Antioxidant](/ingredients/condition/antioxidant) properties derived from its stilbenoid structure (evidence quality not specified in available research)
• [Anti-inflammatory](/ingredients/condition/inflammation) effects through biochemical activity (evidence quality not specified in available research)
• Note: The research dossier lacks specific clinical trial data to support definitive health claims
• Available research focuses primarily on chemical structure and extraction methods
• Clinical evidence for specific health benefits is not documented in the provided research

## Mechanism of Action

Resveratrol activates [sirtuin](/ingredients/condition/longevity) 1 (SIRT1) proteins, which regulate cellular [metabolism](/ingredients/condition/weight-management) and [stress response](/ingredients/condition/stress)s. It inhibits nuclear factor-kappa B (NF-κB) [inflammatory](/ingredients/condition/inflammation) signaling while scavenging [reactive oxygen species](/ingredients/condition/antioxidant) through its phenolic hydroxyl groups. The compound also modulates nitric oxide synthase activity in vascular endothelium.

## Clinical Summary

Human studies on resveratrol show mixed results with small sample sizes typically ranging from 20-100 participants. Some trials using 150-500mg daily doses report modest improvements in [inflammatory](/ingredients/condition/inflammation) markers and [endothelial function](/ingredients/condition/heart-health). However, many studies lack sufficient duration and statistical power. The evidence quality remains limited due to inconsistent dosing protocols and short study periods.

## Nutritional Profile

Resveratrol (3,5,4'-trihydroxystilbene) is a polyphenolic stilbenoid compound, not a macronutrient source. Molecular weight: 228.24 g/mol. Found naturally in: red grape skins (50–100 µg/g fresh weight), red wine (0.1–14.3 mg/L, with typical range 1.5–3.0 mg/L), peanuts (~0.01–1.8 µg/g), Japanese knotweed (Polygonum cuspidatum, richest dietary source at ~187–524 µg/g dry root), blueberries (~32 µg/g fresh weight), cranberries (~17 µg/g), and dark chocolate (~0.4 µg/g). Exists in two geometric isomers: trans-resveratrol (more biologically active and thermodynamically stable) and cis-resveratrol. Key bioactive compounds co-occurring in natural sources include other stilbenoids (piceatannol, pterostilbene, viniferin), flavonoids, and anthocyanins. Contains no macronutrients (protein, fat, carbohydrate), vitamins, minerals, or fiber as an isolated compound. Bioavailability is notably poor: oral bioavailability estimated at <1% due to rapid Phase II [metabolism](/ingredients/condition/weight-management) (extensive glucuronidation and sulfation in the intestine and liver). Peak plasma concentration of free resveratrol after a 25 mg oral dose is approximately 1–5 ng/mL (reached within 0.5–1.5 hours). Total metabolite plasma levels (resveratrol-3-O-sulfate, resveratrol-3-O-glucuronide, resveratrol-4'-O-glucuronide, dihydroresveratrol) can reach ~400–500 ng/mL, suggesting metabolites may contribute to biological effects. Half-life of free resveratrol in plasma is approximately 8–14 minutes; total resveratrol metabolites have a half-life of ~9.2 hours. Absorption rate is estimated at ~70% of oral dose (primarily as metabolites). Micronized or lipid-encapsulated formulations and co-administration with piperine (bioenhancer) may improve bioavailability by 2–5 fold. Typical supplement doses range from 100–1,500 mg/day of trans-resveratrol, far exceeding dietary intake from foods (estimated at 0.5–4 mg/day in moderate red wine consumers). Enterohepatic recirculation may provide sustained low-level exposure. Protein binding in plasma is approximately 90–98%, primarily to albumin and lipoproteins.

## Dosage & Preparation

No clinically studied dosage ranges are provided in the available research. Forms mentioned include the trans-isomer as the stable, bioactive form, which can be extracted from grape sources. Consult a healthcare provider before starting any new supplement.

## Safety & Drug Interactions

Resveratrol is generally well-tolerated at doses up to 1000mg daily, though gastrointestinal upset may occur at higher doses. It may interact with anticoagulant medications due to potential blood-thinning effects. The compound can interfere with certain chemotherapy drugs by affecting cellular pathways. Pregnant and breastfeeding women should avoid supplementation due to insufficient safety data.

## Scientific Research

The research dossier contains no specific clinical trials, RCTs, or meta-analyses with PMIDs for resveratrol. The available research focuses on chemical characterization and extraction methods rather than clinical outcomes.

## Historical & Cultural Context

The research dossier contains no information about traditional or historical medicinal uses of resveratrol. The compound's discovery and use appear to be primarily modern, related to its identification in grape products.

## Synergistic Combinations

Pterostilbene, piceatannol, grape seed extract, quercetin, vitamin C

## Known Interactions

| Substance | Severity | Summary | URL |
|---|---|---|---|
| Warfarin | MODERATE | 🟡 MODERATE — Resveratrol may increase Warfarin bleeding risk. | https://ingredients.hermeticasuperfoods.com/interactions/warfarin |
| Acetyl-L-Carnitine | SAFE | 🟢 SAFE — Resveratrol and Acetyl-L-Carnitine can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/acetyl-l-carnitine |
| Alpha-Lipoic Acid | SAFE | 🟢 SAFE — Resveratrol and Alpha-Lipoic Acid can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/alpha-lipoic-acid |
| Taurine | SAFE | 🟢 SAFE — Resveratrol and Taurine can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/taurine |
| Glycine | SAFE | 🟢 SAFE — Resveratrol and Glycine can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/glycine |
| PEA | SAFE | 🟢 SAFE — Resveratrol and PEA can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/pea |
| CBD Oil | SAFE | 🟢 SAFE — Resveratrol and CBD Oil can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/cbd-oil |
| MCT Oil | SAFE | 🟢 SAFE — Resveratrol and MCT Oil can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/mct-oil |
| D-Mannose | SAFE | 🟢 SAFE — Resveratrol and D-Mannose can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/d-mannose |
| Beta-Alanine | SAFE | 🟢 SAFE — Resveratrol and Beta-Alanine can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/beta-alanine |
| Citrulline | SAFE | 🟢 SAFE — Resveratrol and Citrulline can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/citrulline |
| Tyrosine | SAFE | 🟢 SAFE — Resveratrol and Tyrosine can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/tyrosine |
| Phosphatidylserine | SAFE | 🟢 SAFE — Resveratrol and Phosphatidylserine can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/phosphatidylserine |
| Bacopa Monnieri | SAFE | 🟢 SAFE — Resveratrol and Bacopa Monnieri can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/bacopa-monnieri |
| Mucuna Pruriens | SAFE | 🟢 SAFE — Resveratrol and Mucuna Pruriens can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/mucuna-pruriens |
| Dapagliflozin | SAFE | 🟢 SAFE — Resveratrol and Dapagliflozin can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/dapagliflozin |
| Sitagliptin | SAFE | 🟢 SAFE — Resveratrol and Sitagliptin can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/sitagliptin |
| Pioglitazone | SAFE | 🟢 SAFE — Resveratrol and Pioglitazone can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/pioglitazone |
| Linagliptin | SAFE | 🟢 SAFE — Resveratrol and Linagliptin can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/linagliptin |
| Telmisartan | SAFE | 🟢 SAFE — Resveratrol and Telmisartan can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/telmisartan |

## Frequently Asked Questions

### What foods contain resveratrol naturally?

Red grape skins contain the highest concentrations at 50-100 micrograms per gram. Red wine provides 0.2-5.8mg per liter, while blueberries and cranberries contain smaller amounts around 32-35 micrograms per gram.

### How much resveratrol should I take daily?

Most studies use doses between 150-500mg daily, though optimal dosing remains unclear. Some research suggests 250mg twice daily may improve bioavailability compared to single large doses.

### Does resveratrol really activate longevity genes?

Resveratrol directly activates SIRT1 proteins, which are involved in cellular stress responses and metabolism. However, whether this translates to actual longevity benefits in humans requires more long-term research.

### Can resveratrol help with weight loss?

Some small studies suggest resveratrol may modestly improve metabolic markers, but evidence for significant weight loss is limited. Most trials show minimal effects on body weight compared to placebo.

### Is resveratrol better absorbed with food?

Yes, taking resveratrol with meals containing fat can improve absorption since it's lipophilic. However, bioavailability remains low due to rapid metabolism by the liver, regardless of timing.

### Does resveratrol interact with blood thinners or anticoagulant medications?

Resveratrol may have mild antiplatelet effects due to its antioxidant properties, which could theoretically potentiate blood-thinning medications like warfarin or aspirin. While clinical evidence of significant interaction is limited, individuals taking anticoagulants should consult their healthcare provider before supplementing with resveratrol. This is especially important at higher doses or when combined with multiple supplements that affect blood clotting.

### Is resveratrol safe to take during pregnancy or while breastfeeding?

There is insufficient clinical data to establish the safety of resveratrol supplementation during pregnancy or lactation, and it is generally recommended to avoid supplementation during these periods. While resveratrol occurs naturally in small amounts in foods like grapes, concentrated supplement doses have not been adequately studied in pregnant or nursing populations. Pregnant and breastfeeding women should consult their healthcare provider before considering resveratrol supplements.

### What is the difference between resveratrol from red wine, grapes, and synthetic or extracted resveratrol supplements?

Red wine contains resveratrol naturally but in very small amounts (typically 0.3–1.3 mg per glass), making it an impractical source for therapeutic dosing; grapes and grape skin extracts provide more concentrated natural sources. Synthetic resveratrol supplements are chemically identical to the natural compound but bypass the need for large food volumes, though bioavailability may vary depending on formulation and whether food is consumed alongside the supplement. The choice between sources depends on dosage goals, as supplement forms allow for standardized, measurable intake that food sources alone cannot reliably provide.

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*Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com*
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