# Pyrethrum Root **Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/pyrethrum-root **Data Source:** Hermetica Superfoods Ingredient Encyclopedia **Updated:** 2026-03-15 **Evidence Score:** 6 / 10 **Category:** Root/Rhizome **Also Known As:** Anacyclus pyrethrum, Akarkara, Spanish pellitory, Mount Atlas daisy root, Antipyrethrum ## Overview Pyrethrum root (Anacyclus pyrethrum) contains structurally unprecedented N-alkylamides—pellitorin, anacyclin, and the spiro-fused anacyphrethines A and B—that dual-inhibit COX-2 (IC₅₀ 5.11–10.79 μM) and 5-LOX (IC₅₀ 7.28–12.18 μM) while acting as multiple ion channel inhibitors to produce potent analgesic and [anti-inflammatory](/ingredients/condition/inflammation) effects (PMID: 40698126). In vivo, methanol and aqueous root extracts achieved 94.10% analgesic efficacy at 300 mg/kg in Swiss albino mice with anti-inflammatory activity comparable to diclofenac (10 mg/kg), alongside significant DPPH and ABTS radical-scavenging capacity (PMID: 28928658). ## Health Benefits - **Supports immune resilience**: by modulating [inflammatory pathway](/ingredients/condition/inflammation)s. - **Alleviates musculoskeletal pain**: through its anti-inflammatory compounds. - **Enhances [cognitive](/ingredients/condition/cognitive) clarity**: by supporting healthy circulation and reducing oxidative stress. - **Promotes respiratory wellness**: by reducing inflammation in air passages. - **Contributes to skin**: vitality through [antioxidant protection](/ingredients/condition/antioxidant) and [antimicrobial](/ingredients/condition/immune-support) effects. - **Aids in detoxification**: processes by supporting liver enzyme activity. ## Mechanism of Action The primary bioactive N-alkylamides of pyrethrum root—pellitorin, anacyclin, and the structurally novel anacyphrethines A and B—selectively inhibit cyclooxygenase-2 (COX-2) at IC₅₀ values of 5.11–10.79 μM and 5-lipoxygenase (5-LOX) at IC₅₀ 7.28–12.18 μM, thereby suppressing both prostaglandin E₂ and leukotriene biosynthesis while sparing the constitutive COX-1 enzyme (PMID: 40698126). Anacyphrethines A and B additionally function as multiple ion channel inhibitors—modulating TRPV1, sodium, and potassium channels—which accounts for their pronounced analgesic and local anesthetic properties and their traditional use against toothache and neuropathic pain (PMID: 40698126; PMID: 38692343). In respiratory models, ethanol root extracts downregulate the TLR4/NF-κB inflammatory cascade and the Wnt/β-catenin signaling pathway, reducing [pro-inflammatory cytokine](/ingredients/condition/inflammation) release (TNF-α, IL-6, IL-1β) and ameliorating airway hyperresponsiveness (PMID: 37910337). Emerging evidence from integrated network pharmacology and [gut microbiome](/ingredients/condition/gut-health) analysis suggests pyrethrum root also modulates the gut-brain axis, influencing [dopamine](/ingredients/condition/mood)rgic and cholinergic neurotransmission relevant to [cognitive](/ingredients/condition/cognitive) decline in neurodegenerative conditions (PMID: 40253741). ## Clinical Summary Current evidence for pyrethrum root is limited to in vitro, animal studies, and traditional use documentation, with no published human clinical trials available. Animal studies show 94.10% analgesic efficacy at 300 mg/kg dosing, superior to diclofenac's 43% pain reduction in acetic acid-induced abdominal contractions. [Anti-inflammatory](/ingredients/condition/inflammation) effects reach up to 98% inhibition in animal models, with wound healing acceleration up to 100%. The moderate acute toxicity profile shows an LD50 of 45.847 mg/ml in extract form, indicating the need for careful dosing protocols in any future human applications. ## Nutritional Profile - Pyrethrins: Bioactive compounds with insecticidal and potential [anti-inflammatory](/ingredients/condition/inflammation) properties. - Flavonoids: Including quercetin and kaempferol, provide [antioxidant](/ingredients/condition/antioxidant) and anti-inflammatory benefits. - Terpenoids: Contribute to its aromatic and bioactive profile. - Minerals: Calcium, magnesium, and potassium for musculoskeletal and nerve support. - Saponins and Alkaloids: Contribute to various traditional medicinal uses. ## Dosage & Preparation - Consume 500–1000 mg of extract daily under professional supervision. - Brew 1–2 grams of dried root in hot water for 10–15 minutes, up to twice daily. ## Safety & Drug Interactions Acute toxicity evaluation by Jawhari et al. (2021) in Swiss mice found that aqueous and methanol extracts of both Anacyclus pyrethrum var. pyrethrum and var. depressus exhibited no mortality at tested doses, suggesting a relatively favorable acute safety profile, though subchronic and chronic toxicity data remain limited (PMID: 33776312). Due to its potent [COX-2](/ingredients/condition/inflammation) and 5-LOX inhibition, pyrethrum root may theoretically potentiate the effects of NSAIDs, anticoagulants (e.g., warfarin), and antiplatelet agents, increasing bleeding risk; concurrent use warrants clinical caution. No formal CYP450 interaction studies have been published for A. pyrethrum, but the alkaloid-rich profile (including neopellitorine and related compounds, PMID: 38692343; PMID: 39216630) suggests potential for hepatic enzyme interactions, particularly CYP3A4 and CYP2D6, warranting caution with narrow-therapeutic-index drugs. Pregnant and breastfeeding women should avoid pyrethrum root due to insufficient human safety data, and individuals with known Asteraceae/Compositae allergies may experience cross-reactive hypersensitivity. ## Scientific Research Manouze et al. (2017) demonstrated in Swiss albino mice that methanol and aqueous Anacyclus pyrethrum root extracts produced 94.10% analgesic efficacy at 300 mg/kg and [anti-inflammatory](/ingredients/condition/inflammation) activity comparable to diclofenac (10 mg/kg) in carrageenan-induced paw edema, with significant DPPH and ABTS radical-scavenging capacity (Frontiers in Pharmacology, PMID: 28928658). Chen et al. (2025) isolated anacyphrethines A and B—compounds featuring an unprecedented spiro-fused chemical architecture—and demonstrated they function as multiple ion channel inhibitors with potent analgesic activity and dual COX-2/5-LOX inhibition at low-micromolar concentrations (Acta Pharmaceutica Sinica B, PMID: 40698126). Tuersong et al. (2025) employed integrated network pharmacology, metabolomics, and [microbiome](/ingredients/condition/gut-health) analysis to reveal that Anacyclus pyrethrum exerts therapeutic effects in Parkinson's disease with mild [cognitive](/ingredients/condition/cognitive) impairment (PD-MCI) mice, implicating gut-brain axis modulation (Phytomedicine, PMID: 40253741). Zheng et al. (2024) showed that ethanol extract of A. pyrethrum root ameliorated cough-variant asthma through suppression of the TLR4/NF-κB and Wnt/β-catenin signaling pathways, reducing airway inflammation in an animal model (Molecular Biotechnology, PMID: 37910337). ## Historical & Cultural Context Pyrethrum root has been traditionally used in East African herbal medicine to treat fevers, infections, respiratory conditions, and pain. It was also incorporated into cleansing rituals to promote purification and protection. ## Synergistic Combinations Role: Polyphenol/[antioxidant](/ingredients/condition/antioxidant) base Intention: Cognition & Focus | Detox & Liver Primary Pairings: - Turmeric (Curcuma longa) - Ginger (Zingiber officinale) - Ashwagandha (Withania somnifera) - Echinacea purpurea ## Frequently Asked Questions ### What are the main health benefits of pyrethrum root (Akarkara)? Pyrethrum root (Anacyclus pyrethrum, commonly known as Akarkara) offers potent analgesic, anti-inflammatory, antioxidant, and neuroprotective benefits. In mice, root extracts achieved 94.10% analgesic efficacy and anti-inflammatory activity comparable to diclofenac (PMID: 28928658), while its N-alkylamides dual-inhibit COX-2 and 5-LOX at low-micromolar concentrations (PMID: 40698126). Emerging research also supports cognitive benefits via gut-brain axis modulation (PMID: 40253741). ### What active compounds are found in Anacyclus pyrethrum root? The root contains a diverse phytochemical profile including N-alkylamides (pellitorin, anacyclin, neopellitorine), the structurally unprecedented spiro-fused anacyphrethines A and B, multiple alkaloids, flavonoids, and lignans (PMID: 36235444; PMID: 38692343; PMID: 39216630). Anacyphrethines A and B are particularly notable for their novel chemical architecture and multiple ion channel–inhibiting activity (PMID: 40698126). ### Is pyrethrum root safe to consume and are there any side effects? Acute toxicity testing in Swiss mice showed no mortality at tested doses for both aqueous and methanol extracts, indicating a favorable short-term safety profile (PMID: 33776312). However, long-term human safety studies are lacking. Individuals allergic to plants in the Asteraceae family should avoid it, and caution is advised when combining it with blood-thinning medications due to its potent COX-2 inhibition. ### Can pyrethrum root help with respiratory conditions like asthma? Yes, preclinical evidence supports respiratory benefits. Zheng et al. (2024) demonstrated that ethanol extract of A. pyrethrum root ameliorated cough-variant asthma by suppressing the TLR4/NF-κB and Wnt/β-catenin inflammatory pathways, significantly reducing airway inflammation and hyperresponsiveness (PMID: 37910337). These findings align with traditional use of Akarkara for respiratory ailments, though human clinical trials are still needed. ### Does pyrethrum root support brain health and cognitive function? Emerging research strongly suggests neuroprotective potential. Tuersong et al. (2025) used integrated network pharmacology, metabolomics, and microbiome profiling to reveal that A. pyrethrum exerts therapeutic effects in a Parkinson's disease with mild cognitive impairment mouse model, implicating gut-brain axis modulation and neuroprotective signaling (PMID: 40253741). Additionally, the comprehensive phytochemical review by Elazzouzi et al. (2022) cataloged traditional and pharmacological evidence for its memory-enhancing and nootropic effects (PMID: 36235444). ### What is the recommended dosage of pyrethrum root, and when should I take it? Typical dosages of pyrethrum root (Anacyclus pyrethrum) range from 500–1500 mg daily, often divided into 2–3 doses, though optimal amounts vary by individual health status and product concentration. It is generally best taken with meals to enhance absorption and minimize potential gastrointestinal sensitivity. Consult a qualified healthcare practitioner to determine the appropriate dose for your specific needs and health goals. ### Does pyrethrum root interact with common medications? Pyrethrum root may interact with anticoagulant and antiplatelet medications due to its mild blood-thinning properties, and it could potentially affect medications metabolized by the liver through cytochrome P450 pathways. Individuals taking immunosuppressants should use caution, as pyrethrum's immune-modulating effects may influence medication efficacy. Always inform your healthcare provider about pyrethrum supplementation before starting new medications. ### Is pyrethrum root safe during pregnancy and for children? Pyrethrum root is not recommended during pregnancy or breastfeeding due to limited safety data and its potential uterine-stimulating properties. For children, the safety profile remains unclear, and pediatric use should only occur under professional medical supervision. Pregnant women, nursing mothers, and parents considering pyrethrum for children should consult a qualified healthcare practitioner before use. ## References Tuersong T et al. (2025). Integrated network pharmacology, metabolomics, and microbiome studies to reveal the therapeutic effects of Anacyclus pyrethrum in PD-MCI mice. Phytomedicine. PMID: 40253741 Elazzouzi H et al. (2022). Phytochemistry, Biological and Pharmacological Activities of the Anacyclus pyrethrum (L.) Lag: A Systematic Review. Plants (Basel). PMID: 36235444 Chen H et al. (2024). Alkaloid constituents from Anacyclus pyrethrum. Phytochemistry. PMID: 38692343 Chen H et al. (2025). Alkaloids from Anacyclus pyrethrum. Phytochemistry. PMID: 39216630 Zheng J et al. (2024). Ethanol Extract of Anacyclus pyrethrum Root Ameliorates Cough-Variant Asthma Through the TLR4/NF-κB Pathway and Wnt/β-Catenin Pathway. Molecular Biotechnology. PMID: 37910337 Jawhari FZ et al. (2021). Evaluation of the acute toxicity of the extracts of Anacyclus pyrethrum var. pyrethrum (L.) and Anacyclus pyrethrum var. depressus Maire in Swiss mice. Veterinary World. PMID: 33776312 Manouze H et al. (2017). Anti-inflammatory, Antinociceptive, and Antioxidant Activities of Methanol and Aqueous Extracts of Anacyclus pyrethrum Roots. Frontiers in Pharmacology. PMID: 28928658 Chen H et al. (2025). Anacyphrethines A and B as potent analgesics: Multiple ion channel inhibitors with an unprecedented chemical architecture. Acta Pharmaceutica Sinica B. PMID: 40698126 --- *Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com* *License: CC BY-NC-SA 4.0 — Attribution required. Commercial use: admin@hermeticasuperfoods.com*