Leaf & Herb · Other

Pine Bark Extract (Pycnogenol)

Provisional Strong Scorebotanical

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Pine bark extract (Pycnogenol) is a standardized extract containing proanthocyanidins and catechins that enhance cardiovascular function and provide antioxidant protection. It works by increasing nitric oxide production and stabilizing capillary walls through collagen cross-linking.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryLeaf & Herb

GroupOther

Public Score StatusProvisional Strong

Primary Keywordpine bark extract benefits

Pine Bark Extract (Pycnogenol) — botanical close-up

Reported Benefits (Provisional)

Enhances cardiovascular health by improving endothelial function, leading to better blood flow and reduced blood pressure. Studies show a 12% improvement in blood flow. - Acts as a potent antioxidant, neutralizing free radicals and reducing oxidative stress by up to 30%. This helps in preventing cellular damage. - Supports skin health by increasing skin hydration and elasticity. Clinical trials indicate a 44% improvement in skin elasticity. - Boosts cognitive function by enhancing blood flow to the brain, improving memory and focus. This is particularly beneficial for aging populations. - Reduces inflammation by inhibiting pro-inflammatory enzymes, which can alleviate symptoms of arthritis. - Strengthens immune function by increasing the production of nitric oxide, which aids in pathogen defense. - Improves respiratory health by reducing symptoms of asthma and allergic reactions, enhancing overall lung function.

Origin & History

Natural habitat

Pine Bark Extract, often referred to as Pycnogenol, is derived from the bark of the French maritime pine tree. The bark is harvested and processed to extract oligomeric proanthocyanidins (OPCs), known for their antioxidant properties.

“Used traditionally in European herbal medicine for its healing properties. Gained popularity in the 20th century for its potent antioxidant effects.”Traditional Medicine

Research Narrative (Provisional)

Numerous RCTs and meta-analyses support its role in cardiovascular health and antioxidant protection. Studies also highlight its benefits for skin and cognitive function.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Rich in oligomeric proanthocyanidins (OPCs). - Contains phenolic acids and flavonoids. - Provides essential minerals like potassium and calcium.

Reported Mechanism (Provisional)

Mechanism of Action

Pycnogenol's proanthocyanidins enhance endothelial nitric oxide synthase (eNOS) activity, increasing nitric oxide production for vasodilation. The catechins and procyanidins bind to collagen and elastin fibers, strengthening capillary walls and reducing vascular permeability. These compounds also scavenge hydroxyl radicals and superoxide anions while regenerating vitamins C and E.

Clinical Narrative (Provisional)

Multiple randomized controlled trials with 20-200 participants demonstrate pine bark extract's cardiovascular benefits at 100-200mg daily doses. A meta-analysis of 7 studies showed significant improvements in endothelial function and 12% increases in blood flow. Antioxidant studies consistently report 20-30% reductions in oxidative stress markers. Evidence quality is moderate, with most studies being small-scale but well-controlled.

Also Known As

Pinus pinasterFrench Maritime Pine BarkOPCOligomeric ProanthocyanidinsMaritime Pine ExtractCluster Pine BarkPinaster Bark Extract

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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