Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Oxyresveratrol is a stilbene compound found in mulberry that demonstrates potent antioxidant activity through free radical scavenging mechanisms. This bioactive compound inhibits tyrosinase enzyme activity and provides neuroprotective effects in preliminary research models.
Origin & History
Oxyresveratrol (trans-2,3',4,5'-tetrahydroxystilbene) is a naturally occurring stilbenoid polyphenol found in plants including Artocarpus lakoocha, mulberry wood, Schoenocaulon officinale, and Polygonum multiflorum, where it functions as a phytoalexin. This compound features a trans-1,2-diphenylethylene core structure with four hydroxyl groups—two on each aromatic ring.
Research Narrative (Provisional)
The available research on oxyresveratrol consists primarily of in vitro studies and chemical characterization rather than human clinical trials. No randomized controlled trials (RCTs) or meta-analyses with PubMed PMIDs were identified in the provided research dossier.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
Oxyresveratrol (3,5,3',4'-tetrahydroxystilbene) is a pure polyphenolic stilbene compound, not a whole food ingredient, and therefore does not possess a conventional macronutrient or micronutrient profile. As a discrete phytochemical (molecular weight: 244.24 g/mol; molecular formula: C₁₄H₁₂O₄), its profile is characterized entirely by its bioactive compound identity. It is naturally found in Morus alba (white mulberry) heartwood (concentrations up to 1.0–2.8 mg/g dry weight), Artocarpus lakoocha (up to 10–15% of heartwood extract in some reports), and grape canes (trace levels). As an isolated compound: no caloric value, no fiber, no protein, no vitamins, no minerals. Bioactive concentration in standardized extracts typically ranges from 95–99% purity in research-grade material. Bioavailability notes: Oxyresveratrol demonstrates superior water solubility compared to resveratrol due to its additional hydroxyl group, which may enhance oral bioavailability. It undergoes rapid Phase II metabolism (glucuronidation and sulfation) in the intestinal wall and liver, similar to resveratrol, with peak plasma concentrations (Tmax) reported at approximately 30–60 minutes post-oral administration in rodent models. First-pass metabolism is significant; bioavailability in humans is not yet precisely quantified but estimated to be moderate (>resveratrol baseline). No significant protein, fat, or carbohydrate content applicable.
Reported Mechanism (Provisional)
Oxyresveratrol scavenges reactive oxygen species including hydrogen peroxide and nitric oxide through direct electron donation mechanisms. The compound inhibits tyrosinase enzyme activity, reducing melanin synthesis pathways. In neuronal tissues, oxyresveratrol prevents apoptotic cell death by modulating cellular oxidative stress responses during ischemic conditions.
Clinical Narrative (Provisional)
Current evidence for oxyresveratrol comes primarily from in vitro studies demonstrating antioxidant activity with IC₅₀ values of 45.3 μM for nitric oxide and 28.9 μM for DPPH radical scavenging. Animal model studies show neuroprotective effects against transient cerebral ischemia-induced apoptosis. Human clinical trials evaluating oxyresveratrol supplementation are limited. The evidence base remains preliminary and requires controlled human studies to establish therapeutic efficacy.
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