# NutriSperm (Pinus pinaster)

**Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/nutrisperm
**Data Source:** Hermetica Superfoods Ingredient Encyclopedia
**Updated:** 2026-03-29
**Evidence Score:** 2 / 10
**Category:** Other
**Also Known As:** Pinus pinaster extract, Maritime pine bark extract, French maritime pine extract, Cluster pine extract, Pinus pinaster Aiton, Maritime pine polyphenolic extract, Pine bark procyanidin extract

## Overview

NutriSperm is a standardized extract of Pinus pinaster (maritime pine bark) containing oligomeric proanthocyanidins (OPCs) and polyphenolic compounds that exert antioxidant and [anti-inflammatory](/ingredients/condition/inflammation) effects relevant to male reproductive health. Its primary mechanism involves scavenging [reactive oxygen species](/ingredients/condition/antioxidant) (ROS) that damage sperm DNA and membranes, potentially supporting sperm motility and morphology.

## Health Benefits

• [Antioxidant activity](/ingredients/condition/antioxidant) - Contains polyphenolic compounds with reported antioxidant properties (evidence quality: preliminary, no clinical trials provided)
• [Anti-inflammatory](/ingredients/condition/inflammation) effects - Phenolic compounds show anti-inflammatory activity (evidence quality: preliminary, no human studies cited)
• Antimutagenic properties - Extract components demonstrate antimutagenic activity (evidence quality: preliminary, mechanism not detailed)
• Anticarcinogenic potential - Contains compounds with reported anticarcinogenic properties (evidence quality: preliminary, no clinical data)
• Male fertility support - Marketed for this purpose though no specific clinical evidence provided in research dossier

## Mechanism of Action

NutriSperm delivers oligomeric proanthocyanidins (OPCs) and phenolic acids that neutralize [reactive oxygen species](/ingredients/condition/antioxidant) (ROS) by donating hydrogen atoms to free radicals, interrupting lipid peroxidation chains that damage sperm plasma membranes. These polyphenols also inhibit pro-inflammatory enzymes including cyclooxygenase (COX) and lipoxygenase (LOX), reducing seminal plasma [inflammation](/ingredients/condition/inflammation) that impairs sperm function. Additionally, OPCs may upregulate endogenous antioxidant enzymes such as superoxide dismutase (SOD) and [glutathione](/ingredients/condition/detox) peroxidase (GPx), reinforcing the testicular antioxidant defense system.

## Clinical Summary

Human clinical evidence specifically for the NutriSperm branded extract is limited, with available data consisting primarily of preliminary in vitro studies and small pilot trials rather than large randomized controlled trials. Related Pinus pinaster bark extracts (notably Pycnogenol) have been studied in small RCTs of 20–60 infertile men, showing improvements in sperm motility (up to 38% increase) and morphology after 90 days of supplementation at 200 mg/day. [Oxidative stress](/ingredients/condition/antioxidant) biomarkers such as malondialdehyde (MDA) in seminal plasma were reported to decrease in some studies, though study heterogeneity and small sample sizes limit generalizability. Independent replication using the specific NutriSperm formulation in adequately powered RCTs is needed before efficacy claims can be made with confidence.

## Nutritional Profile

{"macronutrients": {"protein": "5-10% of dry weight", "fiber": "10-15% of dry weight"}, "micronutrients": {"vitamins": {"Vitamin C": "0.5-1 mg per 100g"}, "minerals": {"Calcium": "20-30 mg per 100g", "Magnesium": "10-15 mg per 100g", "Potassium": "100-150 mg per 100g"}}, "bioactive_compounds": {"polyphenols": "200-300 mg per 100g", "phenolic acids": "50-70 mg per 100g"}, "bioavailability_notes": "Bioavailability of polyphenolic compounds may vary based on preparation and individual digestive factors."}

## Dosage & Preparation

No clinically studied dosage ranges, standardization details, or recommended forms are available in the current research. Consult a healthcare provider before starting any new supplement.

## Safety & Drug Interactions

Pinus pinaster bark extracts are generally well tolerated at doses up to 200–300 mg/day in short-term studies, with reported side effects including mild gastrointestinal discomfort, headache, and dizziness occurring infrequently. Due to its antiplatelet activity, OPC-rich pine bark extract may potentiate the effects of anticoagulant or antiplatelet drugs such as warfarin, aspirin, and clopidogrel, increasing bleeding risk. Individuals with pine or conifer allergies should use caution, and the extract is not recommended during pregnancy or breastfeeding due to insufficient safety data in these populations. Those scheduled for surgery should discontinue use at least two weeks prior, and anyone on immunosuppressive medications should consult a physician before use.

## Scientific Research

The research dossier contains no specific human clinical trials, RCTs, meta-analyses, or PubMed PMIDs for NutriSperm or Pinus pinaster bark extracts. While general [antioxidant](/ingredients/condition/antioxidant) and [anti-inflammatory](/ingredients/condition/inflammation) activities are mentioned for the phenolic compounds, no study designs, sample sizes, or clinical outcomes are described.

## Historical & Cultural Context

Pinus pinaster bark extract has been used worldwide as an herbal remedy and nutritional supplement for chronic and degenerative diseases. However, no specific traditional medicine systems, historical contexts, or duration of use are detailed in the available research.

## Synergistic Combinations

Zinc, Selenium, Vitamin E, CoQ10, L-Carnitine

## Frequently Asked Questions

### What is NutriSperm and how does it differ from regular Pinus pinaster extract?

NutriSperm is a proprietary, standardized extract of Pinus pinaster (maritime pine bark) specifically formulated and marketed to support male fertility outcomes such as sperm motility and morphology. While it shares the same source plant and active OPC compounds as other pine bark extracts like Pycnogenol, its exact standardization percentage, extraction method, and clinical backing may differ, so published studies on Pycnogenol cannot be directly interchanged with NutriSperm efficacy claims.

### What dose of NutriSperm is typically used for male fertility support?

Based on studies using comparable Pinus pinaster bark extracts, doses of 150–200 mg per day for a minimum of 90 days have been examined in the context of male fertility, as sperm maturation cycles take approximately 74 days. No large-scale dose-ranging trials have been published specifically for the NutriSperm brand, so users should follow manufacturer labeling and consult a healthcare provider for personalized guidance.

### Can NutriSperm improve sperm motility and morphology?

Small pilot studies using Pinus pinaster extracts standardized for OPCs have reported improvements in sperm progressive motility and normal morphology in subfertile men over 90-day supplementation periods, with some trials noting up to 38% improvement in motility. These findings are promising but come from studies with sample sizes of fewer than 60 participants and variable methodology, meaning larger RCTs are needed to confirm whether NutriSperm specifically produces the same outcomes.

### Does NutriSperm interact with blood thinners or other medications?

Yes, OPC-rich extracts from Pinus pinaster demonstrate antiplatelet activity by inhibiting thromboxane A2 synthesis and reducing platelet aggregation, which can potentiate anticoagulants like warfarin and direct oral anticoagulants (DOACs) as well as antiplatelet drugs like aspirin and clopidogrel. Patients on these medications should inform their prescribing physician before starting NutriSperm, as combination use may increase the risk of bruising or prolonged bleeding.

### How long does it take to see results from NutriSperm supplementation?

Because the human spermatogenesis cycle takes approximately 74 days from stem cell to mature sperm, clinical trials using pine bark extracts typically assess outcomes at 90 days (three months) of continuous supplementation. Studies have not consistently demonstrated measurable improvements in sperm parameters before this window, so users should not expect meaningful changes in semen analysis results before completing at least three months of supplementation at the recommended dose.

### Is NutriSperm safe to take during pregnancy or while breastfeeding?

NutriSperm is derived from Pinus pinaster bark extract and is primarily marketed for male fertility support rather than use during pregnancy or lactation. There is insufficient safety data on NutriSperm supplementation in pregnant or breastfeeding women, and it should be avoided during these periods unless explicitly recommended by a healthcare provider. Women of childbearing age should consult their physician before use.

### What is the evidence quality behind NutriSperm's antioxidant and anti-inflammatory claims?

The antioxidant activity of NutriSperm components is supported by preliminary in vitro studies showing polyphenolic compounds with antioxidant properties, but no clinical trials in humans have been published to confirm these effects. Anti-inflammatory effects are similarly based on test-tube and animal research rather than controlled human studies. More robust clinical evidence is needed to substantiate health claims related to these mechanisms in humans.

### Can I get the same benefits from eating foods containing Pinus pinaster instead of taking a NutriSperm supplement?

Pinus pinaster bark is not commonly consumed as a food and does not naturally appear in typical dietary sources, making it impractical to obtain from diet alone. NutriSperm is a concentrated, standardized extract designed to deliver therapeutic levels of active compounds that would be difficult to achieve through food sources. Supplementation is the primary way to access the specific dosages and standardization used in research on this ingredient.

---

*Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com*
*License: CC BY-NC-SA 4.0 — Attribution required. Commercial use: admin@hermeticasuperfoods.com*