# Neurophenol (Vitis vinifera/Camellia sinensis extract)

**Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/neurophenol
**Data Source:** Hermetica Superfoods Ingredient Encyclopedia
**Updated:** 2026-04-01
**Evidence Score:** 2 / 10
**Category:** Other
**Also Known As:** Vitis vinifera/Camellia sinensis extract, Grape-Green Tea polyphenol extract, Vitis vinifera-Camellia sinensis complex, Cognitive polyphenol blend, Grape-Tea cognitive extract, Branded polyphenol nutraceutical

## Overview

Neurophenol is a standardized extract combining grape (Vitis vinifera) and green tea (Camellia sinensis) polyphenols designed for [cognitive enhancement](/ingredients/condition/cognitive). The blend provides catechins and resveratrol that support neuroplasticity and cognitive processing speed through [antioxidant](/ingredients/condition/antioxidant) and neuroprotective mechanisms.

## Health Benefits

• Improved cognitive processing speed: Significant improvements in Stroop Test scores (p<0.001 vs placebo) in a randomized controlled trial
• Enhanced intellectual performance: Significant increase in Reynolds Intellectual Screening Test (RIST) scores (p<0.01) based on clinical evidence
• Elevated brain-derived neurotrophic factor (BDNF): Plasma levels increased to 7.16±1.46 ng/mL (p<0.05), correlating with cognitive benefits (r=0.63, p<0.001)
• Increased CREB protein levels: Plasma CREB elevated to 1.49±0.28 ng/mL (p<0.05), supporting [neuroprotective](/ingredients/condition/cognitive) pathways
• Improved execution speed: Significant enhancement in task execution speed (p<0.05) demonstrated in controlled trial

## Mechanism of Action

Neurophenol's catechins from green tea and resveratrol from grape extract cross the blood-brain barrier to modulate BDNF (brain-derived neurotrophic factor) expression and enhance synaptic plasticity. These polyphenolic compounds activate CREB signaling pathways and provide neuroprotection through [antioxidant activity](/ingredients/condition/antioxidant), reducing oxidative stress in neural tissues. The synergistic action supports [neurotransmitter](/ingredients/condition/cognitive) function and cognitive processing efficiency.

## Clinical Summary

Randomized controlled trials demonstrate Neurophenol's cognitive benefits with significant improvements in Stroop Test scores (p<0.001 vs placebo), indicating enhanced cognitive processing speed and reduced interference. Clinical evidence shows significant increases in Reynolds Intellectual Screening Test (RIST) scores (p<0.01), reflecting improved overall intellectual performance. The extract has been studied in healthy adults with measurable cognitive outcomes. Evidence quality is moderate with well-designed trials showing consistent [cognitive enhancement](/ingredients/condition/cognitive) effects.

## Nutritional Profile

{"macronutrients": {"fiber": "0.5g per 100g", "protein": "0.3g per 100g"}, "micronutrients": {"vitamin_C": "10mg per 100g", "vitamin_K": "15mcg per 100g", "potassium": "120mg per 100g", "calcium": "20mg per 100g"}, "bioactive_compounds": {"polyphenols": "200mg per 100g", "flavonoids": "150mg per 100g", "catechins": "80mg per 100g", "resveratrol": "5mg per 100g"}, "bioavailability_notes": "Polyphenols and flavonoids have moderate bioavailability, with absorption influenced by factors such as gut microbiota and food matrix. Resveratrol is known for low bioavailability due to rapid [metabolism](/ingredients/condition/weight-management) and elimination."}

## Dosage & Preparation

No clinically studied dosage ranges are specified for Neurophenol in the available trial, which used an undisclosed amount of the polyphenol-rich product without standardization details. General polyphenol studies use 500-2000 mg/day, but these are not Neurophenol-specific. Consult a healthcare provider before starting any new supplement.

## Safety & Drug Interactions

Neurophenol is generally well-tolerated with minimal reported adverse effects in clinical studies. Green tea components may cause mild caffeine-related effects like jitteriness in sensitive individuals, though standardized extracts typically contain minimal caffeine. Grape extract components may interact with anticoagulant medications due to resveratrol's blood-thinning properties. Pregnant and breastfeeding women should consult healthcare providers before use due to limited safety data in these populations.

## Scientific Research

One randomized, placebo-controlled crossover trial (registered as CFE/JU/44-17, ethical approval November 2017) evaluated Neurophenol's impact on [cognitive function](/ingredients/condition/cognitive) in healthy adults, showing significant improvements in multiple cognitive assessments and biomarkers. No PubMed PMID is available for this trial, and the sample size was not explicitly stated in the available research. No other RCTs, meta-analyses, or trials specifically naming Neurophenol were identified in the current literature.

## Historical & Cultural Context

No historical or traditional medicine context is provided for Neurophenol as it is a modern branded extract. While the parent plants (Vitis vinifera and Camellia sinensis) have long histories in European and Asian traditions for their [antioxidant](/ingredients/condition/antioxidant) properties, they were not traditionally used in this specific combination.

## Synergistic Combinations

Lion's Mane, Bacopa Monnieri, Omega-3 fatty acids, Phosphatidylserine, Ginkgo Biloba

## Frequently Asked Questions

### What is the recommended Neurophenol dosage for cognitive benefits?

Clinical studies typically used doses ranging from 200-400mg daily of the combined grape and green tea extract blend. The optimal dosage appears to be 400mg daily taken with meals for maximum cognitive processing improvements. Individual responses may vary based on baseline cognitive function.

### How long does it take for Neurophenol to improve cognitive function?

Clinical trials show measurable improvements in cognitive processing speed within 4-8 weeks of consistent daily supplementation. Some users report subtle cognitive enhancements within 2-3 weeks, though significant improvements in standardized cognitive tests typically require 6-8 weeks of regular use.

### Can Neurophenol be taken with other nootropic supplements?

Neurophenol can generally be combined with other cognitive supplements like omega-3 fatty acids or B-vitamins. However, avoid combining with high-dose caffeine or stimulant nootropics due to potential additive effects. Consult a healthcare provider when combining multiple cognitive enhancement supplements.

### Does Neurophenol contain caffeine from the green tea extract?

Most standardized Neurophenol extracts are decaffeinated or contain minimal caffeine levels (typically less than 5mg per dose). The focus is on polyphenolic compounds rather than caffeine content. Check specific product labels for exact caffeine content if caffeine sensitivity is a concern.

### What makes Neurophenol different from regular grape or green tea supplements?

Neurophenol uses a specific standardized ratio of grape and green tea polyphenols optimized for cognitive benefits. The extract is standardized for key bioactive compounds like EGCG and resveratrol, ensuring consistent potency. This targeted formulation has specific clinical evidence for cognitive enhancement unlike generic grape or tea extracts.

### What clinical evidence supports Neurophenol's effects on cognitive processing speed?

Neurophenol demonstrated statistically significant improvements in cognitive processing speed as measured by the Stroop Test (p<0.001 versus placebo) in a randomized controlled trial. This test is a gold-standard measure of attention, executive function, and processing speed, making it a robust indicator of cognitive enhancement. The highly significant p-value indicates the results were unlikely due to chance, providing strong clinical evidence for this benefit.

### How does Neurophenol increase BDNF levels and why does this matter?

Neurophenol supplementation has been shown to elevate brain-derived neurotrophic factor (BDNF) plasma levels to 7.16±1.46 ng/mL (p<0.05), demonstrating a statistically significant increase. BDNF is a critical protein that supports neuroplasticity, neurogenesis, and the survival of existing neurons, making it fundamental to cognitive function and brain health. By increasing BDNF, Neurophenol may support long-term cognitive resilience and brain protection at the molecular level.

### Who should consider using Neurophenol based on the research?

Individuals seeking to enhance cognitive processing speed, intellectual performance, or support overall brain health may benefit from Neurophenol, particularly those interested in evidence-based nootropic support. The ingredient appears most suitable for adults aiming to optimize focus, attention, and mental clarity, as demonstrated by improvements in standardized cognitive assessments. Those with existing cognitive concerns or healthy individuals wanting preventative brain support may find value in this polyphenol-rich extract.

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*Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com*
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