Hermetica Superfood Encyclopedia
Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.
Review flags: AWAITING_SEMANTIC_VALIDATION
Nettle leaf (Urtica dioica) contains flavonoids including apigenin and kaempferol alongside phenolic acids that inhibit NF-κB activation and suppress pro-inflammatory cytokines. In vitro studies demonstrate 5 mg/mL ethanol extract reduces TNF-α by 50.8% and IL-1β by 99.7% in LPS-stimulated human blood.
Reported Benefits (Provisional)
Origin & History
Nettle Leaf (Urtica dioica) is a widely distributed perennial herb native to Europe, Asia, and North America, thriving in temperate climates with moist, nutrient-rich soils. Revered across diverse traditional medicine systems, it is valued for its potent anti-inflammatory, immune-boosting, and detoxifying properties, making it a cornerstone of holistic wellness.
Research Narrative (Provisional)
Numerous studies, including in vitro, animal models, and some human clinical trials, support Nettle Leaf's anti-inflammatory, antioxidant, and immunomodulatory properties. Research highlights its potential for metabolic regulation, cardiovascular support, and detoxification, validating many of its traditional uses.
Preparation & Dosage
Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.
Nutritional Profile
- Vitamins: A, C, K, E - Minerals: Calcium, Magnesium, Iron, Silica, Zinc - Phytochemicals/Bioactives: Chlorophyll, Polyphenols, Flavonoids, Tannins, Beta-sitosterol, Lignans, Phytosterols, Lecithin - Other: Essential fatty acids (Linoleic acid, Alpha-linolenic acid)
Reported Mechanism (Provisional)
Nettle leaf's flavonoids (apigenin, kaempferol, luteolin) and phenolic acids (chlorogenic, caffeic, ferulic acid) inhibit NF-κB activation by preventing degradation of its inhibitor protein. This suppresses inflammatory cytokine gene expression including TNF-α and IL-1β, while also blocking histamine H1 receptors, COX-1/COX-2 enzymes, and interfering with TLR4 pathway activation in macrophages.
Clinical Narrative (Provisional)
Current evidence is primarily from in vitro and animal studies, with limited human clinical trial data available. Laboratory studies show 5 mg/mL ethanol nettle leaf extract suppressed TNF-α by 50.8% and IL-1β by 99.7% in LPS-stimulated human whole blood samples. Dichloromethane leaf extracts demonstrated potent NF-κB inhibition in RAW 264.7 macrophages compared to other solvent preparations. Animal studies indicate reduced lipid peroxidation in diabetic rat models, but human efficacy data with specific dosages and outcomes remains limited.
Also Known As
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