# Nattokinase

**Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/nattokinase
**Data Source:** Hermetica Superfoods Ingredient Encyclopedia
**Updated:** 2026-03-18
**Evidence Score:** 8 / 10
**Category:** Enzyme
**Also Known As:** Nattokinase enzyme, NK, Natto kinase, Fibrinolytic enzyme, Bacillus subtilis natto protease, Japanese fibrinolytic enzyme, Subtilisin NAT

## Overview

Nattokinase is a fibrinolytic enzyme derived from natto (fermented soybeans) that directly breaks down fibrin to support [cardiovascular health](/ingredients/condition/heart-health). The enzyme works by cleaving fibrin clots and activating plasminogen, promoting healthy blood circulation and reducing thrombotic risk.

## Health Benefits

- Supports [cardiovascular health](/ingredients/condition/heart-health) by promoting healthy blood circulation and reducing blood viscosity, which may lower the risk of clot formation. - Aids in the breakdown of fibrin, a protein involved in blood clotting, helping to maintain clear arteries and optimal blood flow. - May reduce blood pressure by improving vascular flexibility and decreasing arterial stiffness, as shown in studies with reductions of up to 10%. - Enhances heart health by lowering LDL cholesterol and triglyceride levels, contributing to a healthier lipid profile. - Supports healthy aging by protecting against [oxidative stress](/ingredients/condition/antioxidant) and [inflammation](/ingredients/condition/inflammation), both linked to cardiovascular disease. - May improve recovery after physical exertion by reducing muscle soreness and supporting efficient circulation. - Promotes brain health by supporting microcirculation, which can enhance [cognitive function](/ingredients/condition/cognitive) and mental clarity. - Helps maintain normal platelet function, reducing the risk of unwanted clotting events.

## Mechanism of Action

Nattokinase directly cleaves fibrin through its serine protease activity, breaking down existing blood clots and preventing new clot formation. The enzyme also activates tissue plasminogen activator (tPA) and converts plasminogen to plasmin, enhancing the body's natural fibrinolytic system. Additionally, nattokinase inhibits plasminogen activator inhibitor-1 (PAI-1), further promoting clot dissolution.

## Clinical Summary

Human studies using 2000-6000 FU (fibrinolytic units) daily have demonstrated nattokinase's ability to reduce blood viscosity by 8-12% and improve circulation markers within 2-8 weeks. A randomized controlled trial with 86 participants showed significant reductions in fibrinogen levels and improved arterial elasticity after 8 weeks of supplementation. Several smaller studies have reported decreased [blood pressure](/ingredients/condition/heart-health) and improved lipid profiles, though larger long-term trials are needed to confirm cardiovascular protection. The evidence is promising but still emerging, with most studies having 12-week durations and moderate sample sizes.

## Nutritional Profile

- Contains fibrinolytic activity, aiding in blood clot breakdown. - Rich in protein due to its soybean origin. - Contains vitamin K2, important for bone and [cardiovascular health](/ingredients/condition/heart-health).

## Dosage & Preparation

Typical dosage ranges from 100 to 200 mg per day. Consult a healthcare provider before use.

## Safety & Drug Interactions

Nattokinase can increase bleeding risk and should not be combined with anticoagulant medications like warfarin, heparin, or antiplatelet drugs without medical supervision. Common side effects include mild gastrointestinal upset, and rare cases of allergic reactions have been reported in individuals sensitive to soy products. The supplement should be discontinued at least 2 weeks before surgery due to bleeding concerns. Pregnant and breastfeeding women should avoid nattokinase due to insufficient safety data, and individuals with bleeding disorders or recent strokes should consult healthcare providers before use.

## Scientific Research

Clinical trials and observational studies support its role in [cardiovascular health](/ingredients/condition/heart-health), particularly in promoting blood flow and reducing clot formation.

## Historical & Cultural Context

Nattokinase has been used in Japan for centuries as part of the traditional diet, known for its [cardiovascular](/ingredients/condition/heart-health) benefits.

## Synergistic Combinations

CoQ10, Omega-3, Garlic

## Known Interactions

| Substance | Severity | Summary | URL |
|---|---|---|---|
| Fadogia Agrestis | SAFE | Fadogia Agrestis and Nattokinase — No Known Interaction | https://ingredients.hermeticasuperfoods.com/interactions/fadogia-agrestis |
| Lumbrokinase | SAFE | Nattokinase and Lumbrokinase — No Known Interaction | https://ingredients.hermeticasuperfoods.com/interactions/lumbrokinase |
| Wobenzym | SAFE | Nattokinase and Wobenzym — No Known Interaction | https://ingredients.hermeticasuperfoods.com/interactions/wobenzym |
| Monolaurin | SAFE | Nattokinase and Monolaurin — No Known Interaction | https://ingredients.hermeticasuperfoods.com/interactions/monolaurin |
| Turkesterone | SAFE | Nattokinase and Turkesterone — No Known Interaction | https://ingredients.hermeticasuperfoods.com/interactions/turkesterone |
| Cistanche | SAFE | Nattokinase and Cistanche — No Known Interaction | https://ingredients.hermeticasuperfoods.com/interactions/cistanche |
| Apigenin | SAFE | Nattokinase and Apigenin — No Known Interaction | https://ingredients.hermeticasuperfoods.com/interactions/apigenin |
| Emodin | SAFE | Nattokinase and Emodin — No Known Interaction | https://ingredients.hermeticasuperfoods.com/interactions/emodin |
| Sea Moss | SAFE | Nattokinase and Sea Moss — No Known Interaction | https://ingredients.hermeticasuperfoods.com/interactions/sea-moss |
| Spermidine | SAFE | Nattokinase and Spermidine — No Known Interaction | https://ingredients.hermeticasuperfoods.com/interactions/spermidine |
| Urolithin A | SAFE | Nattokinase and Urolithin A — No Known Interaction | https://ingredients.hermeticasuperfoods.com/interactions/urolithin-a |
| Adrafinil | SAFE | Adrafinil and Nattokinase — No Known Interaction | https://ingredients.hermeticasuperfoods.com/interactions/adrafinil |
| Serrapeptase | SAFE | Serrapeptase and Nattokinase — No Known Interaction | https://ingredients.hermeticasuperfoods.com/interactions/serrapeptase |
| Phenibut | SAFE | Phenibut and Nattokinase — No Known Interaction | https://ingredients.hermeticasuperfoods.com/interactions/phenibut |
| Tianeptine | SAFE | Tianeptine and Nattokinase — No Known Interaction | https://ingredients.hermeticasuperfoods.com/interactions/tianeptine |
| Ashwagandha | SAFE | Nattokinase and Ashwagandha — No Known Interaction | https://ingredients.hermeticasuperfoods.com/interactions/ashwagandha |
| Rhodiola Rosea | SAFE | Nattokinase and Rhodiola Rosea — No Known Interaction | https://ingredients.hermeticasuperfoods.com/interactions/rhodiola-rosea |
| Maca Root | SAFE | Nattokinase and Maca Root — No Known Interaction | https://ingredients.hermeticasuperfoods.com/interactions/maca-root |
| Ginseng (Panax) | SAFE | Nattokinase and Ginseng (Panax) — No Known Interaction | https://ingredients.hermeticasuperfoods.com/interactions/panax-ginseng |
| Lions Mane | SAFE | Nattokinase and Lions Mane — No Known Interaction | https://ingredients.hermeticasuperfoods.com/interactions/lions-mane |

## Frequently Asked Questions

### Does nattokinase help dissolve blood clots?

Yes, nattokinase has direct fibrinolytic activity, meaning it can break down existing blood clots. It works through serine protease activity to cleave fibrin, the structural protein of clots. It also activates tissue plasminogen activator (tPA) and converts plasminogen to plasmin, enhancing the body's natural clot-dissolving system. Additionally, it inhibits PAI-1, a protein that normally suppresses clot breakdown. Clinical research supports its role in promoting healthy blood flow and reducing thrombotic risk, though it should not replace prescribed anticoagulant therapy.

### Can nattokinase lower blood pressure?

Research suggests nattokinase may modestly reduce blood pressure. Clinical studies have reported reductions of up to 10% in both systolic and diastolic readings. The proposed mechanism involves improving vascular flexibility and reducing arterial stiffness, which decreases resistance to blood flow. By lowering blood viscosity and supporting healthy circulation, nattokinase may complement lifestyle strategies for blood pressure management. However, it should not substitute prescribed antihypertensive medications without medical supervision.

### Is nattokinase safe to take with blood thinners like warfarin or aspirin?

Nattokinase has significant fibrinolytic and antiplatelet properties, which means combining it with blood thinners such as warfarin, aspirin, or clopidogrel could increase the risk of excessive bleeding. This combination is generally not recommended without direct medical supervision. Because nattokinase enhances the body's natural clot-dissolving pathways and inhibits PAI-1, its additive effect alongside anticoagulants or antiplatelets warrants caution. Always consult a healthcare provider before combining nattokinase with any blood-thinning medication.

### Can nattokinase improve cholesterol levels?

Emerging evidence suggests nattokinase may contribute to a healthier lipid profile by lowering LDL cholesterol and triglyceride levels. While its primary mechanism is fibrinolytic, its anti-inflammatory and antioxidative properties may also support vascular health by reducing oxidative stress linked to lipid oxidation. However, nattokinase is not a replacement for statin therapy or dietary interventions in managing clinically elevated cholesterol. It may serve as a complementary approach alongside heart-healthy lifestyle modifications.

### What are the side effects of nattokinase?

Nattokinase is generally well tolerated at typical doses of 100–200 mg daily. The most notable risk is excessive bleeding due to its blood-thinning properties, particularly in individuals taking anticoagulants or those with bleeding disorders. Some users may experience mild gastrointestinal discomfort. Because natto is derived from fermented soybeans, individuals with soy allergies should exercise caution. Nattokinase is contraindicated before surgery or in those with hemorrhagic conditions. Always consult a healthcare provider before starting supplementation.

### Can nattokinase support brain health and cognitive function?

Nattokinase may support brain health by promoting microcirculation, which ensures adequate oxygen and nutrient delivery to brain tissues. Improved blood flow in cerebral vessels can enhance cognitive function and mental clarity. Its fibrinolytic activity may also help prevent microclot formation that contributes to cognitive decline. Additionally, its antioxidative and anti-inflammatory properties may protect neurons from oxidative damage. While early research is promising, robust clinical trials specifically targeting cognitive outcomes are still needed.

### Does nattokinase help with muscle recovery after exercise?

Nattokinase may support post-exercise recovery by improving circulation, which facilitates faster removal of metabolic waste products such as lactic acid from muscle tissue. Enhanced blood flow can also accelerate delivery of oxygen and nutrients needed for muscle repair. Its anti-inflammatory properties may help reduce exercise-induced muscle soreness. While direct clinical evidence for athletic recovery remains limited, its circulatory benefits provide a plausible mechanism for reduced recovery time and improved physical performance.

### Who should not take nattokinase?

Nattokinase is not suitable for everyone. It should be avoided by individuals taking anticoagulants or antiplatelet medications due to an elevated bleeding risk. Those with bleeding disorders, upcoming surgeries, or a history of stroke related to bleeding should also avoid it. Pregnant or breastfeeding women should consult a doctor before use due to insufficient safety data. Individuals with soy allergies should be cautious given its fermented soybean origin. Anyone with a serious cardiovascular condition should seek medical guidance before supplementing with nattokinase.

### How much nattokinase should I take daily?

Clinical studies typically use 2000-6000 FU (fibrinolytic units) daily, often divided into 2 doses taken on an empty stomach. Most commercial supplements provide 2000 FU per capsule, with 1-2 capsules daily being the standard recommendation.

### How long does it take for nattokinase to work?

Blood viscosity improvements can be measured within 2-4 hours of taking nattokinase, with peak fibrinolytic activity occurring around 8-12 hours post-dose. Clinical benefits like improved circulation markers typically become apparent after 2-8 weeks of consistent supplementation.

### Can I take nattokinase with blood pressure medications?

Nattokinase may enhance the effects of blood pressure medications and could potentially cause excessive blood pressure reduction. It's essential to monitor blood pressure closely and consult with a healthcare provider before combining these treatments.

### Is nattokinase safe for people with vitamin K deficiency?

Nattokinase itself doesn't contain vitamin K2 like traditional natto food, so it doesn't directly affect vitamin K status. However, people with bleeding disorders or vitamin K deficiency should exercise extra caution due to nattokinase's anticoagulant effects.

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*Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com*
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