# Naticol 1000 (Hydrolyzed fish collagen)

**Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/naticol-1000
**Data Source:** Hermetica Superfoods Ingredient Encyclopedia
**Updated:** 2026-03-19
**Evidence Score:** 2 / 10
**Category:** Other
**Also Known As:** Hydrolyzed marine collagen peptides, Fish collagen hydrolysate, Marine collagen peptides, Hydrolyzed fish gelatin, Piscine collagen hydrolysate, Type I marine collagen peptides

## Overview

Naticol 1000 is a low-molecular-weight hydrolyzed fish collagen supplement containing type I collagen peptides that support skin health. It works by providing bioactive peptides that stimulate endogenous [collagen synthesis](/ingredients/condition/skin-health) and hyaluronic acid production in skin tissue.

## Health Benefits

• Improved skin moisturization via upregulated hyaluronic acid synthesis (preclinical evidence only)
• Reduced wrinkle formation through enhanced collagen type I expression and TGF-β pathway activation (animal study evidence)
• Protection against UV-induced skin damage via [antioxidant](/ingredients/condition/antioxidant) enzyme elevation (SOD, catalase, GPx) (mouse model evidence)
• Inhibited melanogenesis for potential skin brightening effects (in vitro evidence only)
• Enhanced ceramide synthesis for improved skin barrier function (preclinical evidence only)

## Mechanism of Action

Naticol 1000 contains low-molecular-weight collagen peptides that activate the TGF-β signaling pathway, promoting collagen type I gene expression and synthesis. These peptides also upregulate hyaluronic acid synthase enzymes, increasing skin moisture retention. Additionally, the collagen fragments enhance [antioxidant](/ingredients/condition/antioxidant) enzyme activity, protecting against UV-induced oxidative damage.

## Clinical Summary

Current evidence for Naticol 1000 is limited to preclinical and animal studies. In vitro studies demonstrate increased hyaluronic acid synthesis in cultured skin cells, while animal models show enhanced collagen type I expression and reduced wrinkle formation. UV protection effects have been observed through elevated [antioxidant](/ingredients/condition/antioxidant) enzyme levels in laboratory settings. Human clinical trials are needed to confirm these preliminary findings and establish effective dosing protocols.

## Nutritional Profile

Naticol 1000 is a low-molecular-weight hydrolyzed fish collagen (average molecular weight ~1000 Da) derived primarily from the skin and scales of wild-caught marine fish (typically cod, haddock, or similar species). **Protein content:** ~90–97% protein (on a dry weight basis), consisting almost entirely of collagen-derived peptides. **Amino acid profile (approximate per 100 g):** Glycine 20–25 g, Proline 10–13 g, Hydroxyproline 10–13 g (a hallmark amino acid of collagen, not found significantly in other dietary proteins), Alanine 8–10 g, Glutamic acid 9–11 g, Arginine 7–9 g, Aspartic acid 5–7 g, Lysine 3–4 g, Serine 3–4 g, Leucine 2–3 g, with lower amounts of other amino acids; notably low or absent in tryptophan and cysteine, making it an incomplete protein by essential amino acid standards. **Bioactive peptides:** Contains prolyl-hydroxyproline (Pro-Hyp) and hydroxyprolyl-glycine (Hyp-Gly) dipeptides and tripeptides (e.g., Gly-Pro-Hyp) that are the primary bioactive fractions responsible for stimulating fibroblast activity and [collagen synthesis](/ingredients/condition/skin-health); these di/tripeptides can reach ~20–30% of total peptide content depending on hydrolysis conditions. **Fat:** <1% (essentially lipid-free). **Carbohydrates:** <1% (negligible). **Minerals:** Sodium ~200–500 mg/100 g (varies by manufacturer processing); trace amounts of calcium (~30–50 mg/100 g), phosphorus (~20–40 mg/100 g), and potassium; generally low in heavy metals (mercury <0.1 ppm, cadmium <0.1 ppm per specification). **Vitamins:** Not a significant source of any vitamins. **Calories:** ~350–380 kcal per 100 g (from protein alone). **Moisture:** Typically 5–8%. **Bioavailability notes:** The low molecular weight (~1000 Da) of Naticol 1000 is specifically engineered for high intestinal absorption; studies on similar fish collagen hydrolysates demonstrate >90% absorption in the gastrointestinal tract. Pro-Hyp and Hyp-Gly dipeptides are resistant to further enzymatic degradation by dipeptidyl peptidase IV and are detected in human plasma within 1–2 hours post-ingestion, reaching peak plasma concentrations of ~20–60 nmol/mL at typical oral doses of 5–10 g. These peptides accumulate preferentially in skin tissue. The absence of tryptophan means Naticol should not be relied upon as a sole protein source. Standard recommended dose is 2.5–10 g/day dissolved in liquid.

## Dosage & Preparation

No clinically studied dosages have been established for humans. Preclinical mouse studies used oral supplementation (exact mg/kg not specified). Product is standardized to >93% collagen protein, with the x3Peptide variant containing 25% tripeptides. Consult a healthcare provider before starting any new supplement.

## Safety & Drug Interactions

Naticol 1000 is generally well-tolerated with minimal reported side effects. Individuals with fish allergies should avoid this supplement due to its marine collagen source. No significant drug interactions have been documented, though concurrent use with anticoagulants should be monitored. Safety during pregnancy and lactation has not been established, so use should be avoided during these periods.

## Scientific Research

No human clinical trials, RCTs, or meta-analyses specifically on Naticol 1000 were identified. Evidence is limited to one preclinical study using HaCaT keratinocytes, Hs27 fibroblasts, B16F10 melanocytes, and UVB-exposed SHK-I hairless mice, showing improvements in skin parameters (P<0.05 vs. UVB control).

## Historical & Cultural Context

No historical or traditional medicine use is documented for Naticol 1000, as it is a modern branded ingredient produced via proprietary enzymatic hydrolysis. General fish collagen hydrolysates lack referenced traditional context in available sources.

## Synergistic Combinations

Vitamin C, Hyaluronic acid, Ceramides, Astaxanthin, Vitamin E

## Frequently Asked Questions

### What is the recommended dosage of Naticol 1000?

While specific dosage recommendations vary by manufacturer, studies typically use 1-10 grams daily. The 'Naticol 1000' designation refers to the molecular weight profile rather than dosage amount.

### How long does it take to see results from Naticol 1000?

Based on collagen supplement research, visible skin improvements typically appear after 4-8 weeks of consistent use. However, specific timing for Naticol 1000 requires more human clinical data to confirm.

### Can Naticol 1000 be taken with other collagen supplements?

Yes, Naticol 1000 can generally be combined with other collagen types or beauty supplements. However, total collagen intake should not exceed 20 grams daily to avoid digestive discomfort.

### Is Naticol 1000 better than bovine collagen for skin health?

Fish collagen like Naticol 1000 has smaller peptides and better bioavailability than bovine collagen. It's also predominantly type I collagen, which is the primary collagen type in human skin tissue.

### Does Naticol 1000 work for joint health or only skin?

Naticol 1000 is specifically formulated and studied for skin health benefits. While it contains type I collagen found in joints, marine collagen is less effective for joint support compared to type II collagen from cartilage sources.

### What is the difference between Naticol 1000 and other hydrolyzed fish collagen products?

Naticol 1000 is a branded hydrolyzed fish collagen standardized for molecular weight and amino acid profile, designed specifically for skin health applications. While all hydrolyzed fish collagens share similar amino acid composition, Naticol 1000's formulation is optimized to support hyaluronic acid synthesis and collagen type I expression based on preclinical research. The '1000' designation typically refers to the specific hydrolysis process and peptide size range that may enhance absorption compared to non-standardized fish collagen sources.

### Does Naticol 1000 require any special storage or preparation to maintain its effectiveness?

Naticol 1000 should be stored in a cool, dry place away from direct sunlight and moisture to preserve the integrity of the hydrolyzed peptides. Most hydrolyzed fish collagen powders dissolve easily in cold or warm liquids without requiring special preparation, though mixing with slightly warm water may improve dissolution speed. Avoiding extremely high temperatures (above 60°C) when preparing is recommended to prevent potential degradation of the bioactive peptide structure.

### What does the current research show about Naticol 1000's effectiveness for UV protection and skin brightening?

Preclinical studies in mouse models indicate that Naticol 1000 may boost antioxidant enzymes (SOD, catalase, and glutathione peroxidase) that help protect against UV-induced skin damage, though human clinical data is limited. Animal research also suggests potential melanogenesis inhibition for skin brightening effects, but these findings have not yet been confirmed in human trials. More rigorous clinical studies in humans are needed to establish the practical efficacy and optimal dosing for these specific skin benefits.

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*Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com*
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