Fruit · Nut

Naringenin from Grapefruit

Provisional Moderate ScoreCompound

Hermetica Superfood Encyclopedia

Published March 15, 2026Last updated March 15, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Naringenin is a key flavonoid aglycone found in grapefruit, derived from its glycoside naringin, and is recognized for its potent antioxidant, anti-inflammatory, and metabolic properties. Its primary mechanisms involve inhibiting specific cardiac ion channels and various cytochrome P450 (CYP) enzymes, impacting drug metabolism and cellular processes.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryFruit

GroupNut

Public Score StatusProvisional Moderate

Primary Keywordnaringenin from grapefruit benefits

Naringenin from Grapefruit close-up macro showing natural texture and detail — rich in strong cyp3a4 enzyme inhibition (primary concern), moderate cyp1a2 inhibition, potential p-glycoprotein transporter modulation. activates nrf2 antioxidant pathway

Naringenin from Grapefruit — botanical close-up

Reported Benefits (Provisional)

Neutralizes free radicals, providing potent antioxidant protection and supporting cellular health.

Reduces systemic inflammation, benefiting joint health and overall well-being

Improves cholesterol profiles and regulates blood pressure, promoting cardiovascular health.

Enhances liver detoxification pathways and protects against liver damage

Improves insulin sensitivity and supports healthy blood sugar levels for glucose regulation.

Promotes fat metabolism and inhibits fat accumulation, aiding in weight management.

Enhances immune responses and combats inflammation-driven conditions

Origin & History

Natural habitat

Naringenin is a potent flavonoid primarily found in grapefruits (*Citrus paradisi*), which originated in Barbados as a hybrid of pomelo and sweet orange. This bioactive compound contributes to the tart flavor of grapefruits and offers extensive health benefits, including antioxidant, anti-inflammatory, and metabolic-regulating properties. It is highly valued in functional nutrition for its therapeutic potential in improving cardiovascular health, supporting liver detoxification, and regulating glucose metabolism.

“Naringenin, primarily sourced from grapefruit, has been consumed as part of traditional diets in citrus-growing regions since grapefruit's popularization in the 19th century. While the compound itself is a modern biochemical isolate, its source fruit has been valued for its health-promoting properties. Modern research now highlights Naringenin's potential in managing metabolic syndrome, supporting liver health, and enhancing cardiovascular wellness.”Traditional Medicine

Research Narrative (Provisional)

Extensive research, including in vitro, animal, and some human clinical studies, investigates Naringenin's antioxidant, anti-inflammatory, and metabolic-regulating properties. Studies explore its potential in cardiovascular health, liver support, and glucose metabolism. Further robust human clinical trials are needed to fully establish its therapeutic applications and optimal dosages.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Naringenin (flavonoid) - Other Polyphenols

Reported Mechanism (Provisional)

Mechanism of Action

Naringenin, released from naringin by gut hydrolysis, primarily acts through inhibiting cardiac ion channels like hERG, with reported IC50 values ranging from 36.5 μM in HEK cells to 102.6 μM. Additionally, it strongly inhibits various cytochrome P450 (CYP) enzymes, including CYP3A4, CYP2C9, CYP2C19, and CYP19, thereby influencing drug metabolism and toxin bioactivation.

Clinical Narrative (Provisional)

Extensive research on Naringenin, encompassing in vitro and animal models, highlights its antioxidant, anti-inflammatory, and metabolic-regulating properties, exploring its potential in cardiovascular health, liver support, and glucose metabolism. While some human clinical studies exist, these are not consistently robust, lacking specific sample sizes and clear outcome data in the provided research. Consequently, further comprehensive and well-designed human trials are needed to fully establish its clinical efficacy and therapeutic applications.

Also Known As

Citrus paradisiGrapefruit flavonoidNaringin aglycone

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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