Nucleotide & Cofactor · Vitamin

NADH (Reduced NAD+)

Provisional Moderate Scorenucleotide

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

NADH (nicotinamide adenine dinucleotide) is the reduced coenzyme form of NAD+ that directly transfers electrons in cellular energy production. It functions as a primary electron donor in the mitochondrial electron transport chain, facilitating ATP synthesis for cellular energy.

—

Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryNucleotide & Cofactor

GroupVitamin

Public Score StatusProvisional Moderate

Primary KeywordNADH benefits

NADH close-up macro showing natural texture and detail — rich in coenzyme, antioxidant, neuroprotective

NADH (Reduced NAD+) — botanical close-up

Reported Benefits (Provisional)

Enhances cellular energy production by facilitating ATP synthesis, crucial for sustained energy levels. - Supports cognitive function by increasing neurotransmitter production, which may improve concentration and mental clarity. - May reduce fatigue by optimizing cellular respiration, leading to increased endurance during physical activities. - Promotes cardiovascular health by improving blood flow and reducing oxidative stress. - Supports mood regulation by enhancing serotonin production, potentially reducing symptoms of depression. - Aids in the management of chronic fatigue syndrome by improving mitochondrial efficiency, offering a 25% increase in energy levels. - Boosts athletic performance by enhancing muscle contraction efficiency, leading to improved physical output.

Origin & History

Natural habitat

NADH is a coenzyme found in all living cells, derived from vitamin B3 (niacin). It is produced during the Krebs cycle in mitochondria. Commercially, NADH is extracted and stabilized for supplementation.

“NADH was discovered as a part of the study of cellular respiration. It has been used in Europe for decades as a supplement to boost energy and cognitive function.”Traditional Medicine

Research Narrative (Provisional)

Numerous studies, including randomized controlled trials, have explored NADH's effects on energy and cognitive function. Some studies suggest benefits for chronic fatigue syndrome and Parkinson's disease.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- NADH is a derivative of niacin (vitamin B3). - It plays a critical role in the electron transport chain. - Contains high-energy electrons used in ATP production.

Reported Mechanism (Provisional)

Mechanism of Action

NADH donates electrons to Complex I (NADH dehydrogenase) in the mitochondrial electron transport chain, driving proton pumping across the inner mitochondrial membrane. This creates the electrochemical gradient necessary for ATP synthase to produce ATP from ADP. NADH also serves as a cofactor for enzymes involved in neurotransmitter synthesis, including tyrosine hydroxylase for dopamine production.

Clinical Narrative (Provisional)

Small-scale clinical trials with 20-50 participants have shown modest improvements in fatigue and cognitive performance with 10-20mg daily NADH supplementation. A 12-week study in chronic fatigue syndrome patients found 31% reported improved energy levels versus 8% in placebo group. However, larger randomized controlled trials are limited, and bioavailability concerns exist due to NADH's instability in stomach acid. Current evidence suggests potential benefits but requires more robust clinical validation.

Also Known As

Nicotinamide adenine dinucleotide (reduced)Reduced nicotinamide adenine dinucleotideDihydronicotinamide adenine dinucleotideDPNHCoenzyme 1 (reduced form)β-NADHNAD hydride

Browse All Ingredients More Vitamin About the Encyclopedia

These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

From the Hermetica Research Desk

Research updates — and 25% off your first order

Join our list for source-aware wellness education, review-state updates, and product news — and unlock 25% off your first Hermetica order. Educational content is not medical advice. No spam, unsubscribe anytime.

Educational content only — not medical advice.