# Myanmar Pyin Oo Lwin Coffee (Coffea arabica 'Myanmar Pyin Oo Lwin')

**Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/myanmar-pyin-oo-lwin-coffee
**Data Source:** Hermetica Superfoods Ingredient Encyclopedia
**Updated:** 2026-03-31
**Evidence Score:** 2 / 10
**Category:** Coffee Cultivars
**Also Known As:** Pyin Oo Lwin Coffee, Myanmar Highland Coffee, Pyin U Lwin Coffee, Maymyo Coffee, Burma Pyin Oo Lwin Arabica, Myanmar Mountain Coffee

## Overview

Myanmar Pyin Oo Lwin Coffee (Coffea arabica cultivated in the Pyin Oo Lwin highlands of Myanmar) delivers caffeine and chlorogenic acids as its primary bioactive compounds, which modulate adenosine receptors and inhibit glucose-6-phosphatase to influence alertness and [glucose metabolism](/ingredients/condition/weight-management). No cultivar-specific clinical trials exist, so health effects are extrapolated from broader Coffea arabica and chlorogenic acid research.

## Health Benefits

• No clinical evidence exists for this specific cultivar - general C. arabica benefits may apply but are not verified for this variant
• Potential caffeine-related alertness effects based on general coffee research (no cultivar-specific studies)
• Possible [glucose metabolism](/ingredients/condition/weight-management) support via chlorogenic acids found in standard C. arabica (no cultivar-specific data)
• May contain [antioxidant](/ingredients/condition/antioxidant) polyphenols typical of C. arabica (no quantitative analysis available)
• Theoretical adenosine receptor modulation effects from caffeine content (no clinical verification for this variant)

## Mechanism of Action

Caffeine in Coffea arabica competitively antagonizes adenosine A1 and A2A receptors in the central nervous system, reducing inhibitory neurotransmission and increasing [dopamine](/ingredients/condition/mood)rgic and noradrenergic signaling to promote wakefulness. Chlorogenic acids, particularly 5-caffeoylquinic acid, inhibit the enzyme glucose-6-phosphatase in the liver, potentially blunting postprandial glucose spikes by slowing hepatic glucose release. Additionally, chlorogenic acids may activate AMP-activated protein kinase (AMPK), a key regulator of cellular energy homeostasis, though this has not been confirmed in this specific cultivar.

## Clinical Summary

No peer-reviewed clinical trials have been conducted specifically on Myanmar Pyin Oo Lwin Coffee or its extracts, making cultivar-specific efficacy claims unsupported by direct evidence. General Coffea arabica research, including randomized controlled trials in cohorts of 50–200 participants, has associated chlorogenic acid intake (200–400 mg/day) with modest reductions in fasting [blood glucose](/ingredients/condition/weight-management) of approximately 5–10 mg/dL. Meta-analyses of coffee consumption studies suggest a dose-dependent association with reduced type 2 diabetes risk, but these findings cannot be attributed to this specific highland Myanmar cultivar without independent phytochemical profiling and clinical testing. Evidence quality for this particular ingredient remains very low, and all purported benefits are extrapolated from general Arabica coffee literature.

## Nutritional Profile

{"macronutrients": {"carbohydrates": "0.2g per 100ml brewed coffee", "protein": "0.1g per 100ml brewed coffee", "fat": "0g per 100ml brewed coffee"}, "micronutrients": {"potassium": "116mg per 100ml brewed coffee", "magnesium": "7mg per 100ml brewed coffee", "niacin (Vitamin B3)": "0.5mg per 100ml brewed coffee"}, "bioactive_compounds": {"caffeine": "40mg per 100ml brewed coffee", "chlorogenic acids": "70mg per 100ml brewed coffee", "polyphenols": "80mg per 100ml brewed coffee"}, "bioavailability_notes": "The bioavailability of caffeine and chlorogenic acids can vary based on brewing method and individual [metabolism](/ingredients/condition/weight-management). Polyphenols are generally well-absorbed but can be influenced by the presence of other dietary components."}

## Dosage & Preparation

No clinically studied dosage ranges exist for this specific cultivar. General C. arabica coffee consumption is typically 1-3 cups daily (70-210 mg caffeine), but standardization data for Pyin Oo Lwin variants is unavailable. Consult a healthcare provider before starting any new supplement.

## Safety & Drug Interactions

As a Coffea arabica cultivar, Myanmar Pyin Oo Lwin Coffee carries caffeine-related risks including anxiety, [insomnia](/ingredients/condition/sleep), tachycardia, and elevated [blood pressure](/ingredients/condition/heart-health) at doses exceeding 400 mg caffeine per day in healthy adults. It may interact with anticoagulants such as warfarin, as chlorogenic acids can modestly affect platelet aggregation, and caffeine can increase the clearance of clozapine and other CYP1A2-metabolized drugs. Pregnant individuals are advised to limit total caffeine intake to under 200 mg per day due to associations between high caffeine exposure and reduced fetal birth weight. Individuals with anxiety disorders, cardiac arrhythmias, or gastroesophageal reflux disease should exercise caution due to caffeine's stimulant and acid-secretion-promoting properties.

## Scientific Research

No clinical trials, RCTs, or meta-analyses specific to Myanmar Pyin Oo Lwin Coffee were identified in PubMed or other databases. All available evidence relates to general Coffea arabica studies rather than this specific cultivar variant.

## Historical & Cultural Context

Myanmar Pyin Oo Lwin Coffee has no documented traditional medicinal use, being primarily a commercial crop introduced in the 1800s for beverage production. The cultivar represents colonial agricultural development rather than indigenous medicinal tradition.

## Synergistic Combinations

L-theanine, green tea extract, guarana, rhodiola, ginseng

## Frequently Asked Questions

### What makes Myanmar Pyin Oo Lwin Coffee different from other Arabica coffees?

Pyin Oo Lwin (formerly Maymyo) sits at approximately 1,070 meters elevation in Myanmar's Mandalay Region, where cooler temperatures slow coffee cherry development and can concentrate organic acids and aromatic compounds in the bean. However, no published phytochemical comparison study has quantified whether its chlorogenic acid or caffeine content differs meaningfully from other Arabica cultivars. Until such profiling is done, its biochemical distinction from standard Coffea arabica remains unconfirmed.

### Does Myanmar Pyin Oo Lwin Coffee help with blood sugar control?

Extrapolating from general Coffea arabica research, chlorogenic acids (particularly 5-caffeoylquinic acid) in Arabica coffee inhibit hepatic glucose-6-phosphatase, which may reduce postprandial blood glucose elevations. Studies using standardized green coffee extract containing 400 mg chlorogenic acids daily showed fasting glucose reductions of roughly 5–10 mg/dL over 8–12 weeks in pre-diabetic adults. No studies have tested this specific Myanmar cultivar for glucose metabolism effects, so these outcomes cannot be directly attributed to it.

### How much caffeine is in Myanmar Pyin Oo Lwin Coffee?

No published laboratory analysis has specifically measured the caffeine content of Myanmar Pyin Oo Lwin Coffee beans. Standard Coffea arabica beans contain approximately 1.2–1.5% caffeine by dry weight, yielding roughly 80–120 mg of caffeine per 8-ounce brewed cup depending on grind, brew method, and roast level. Until cultivar-specific testing is performed, these general Arabica figures are the best available estimate.

### Is Myanmar Pyin Oo Lwin Coffee safe to drink every day?

For most healthy adults, moderate consumption of up to 3–4 cups of brewed Arabica coffee per day (approximately 300–400 mg caffeine) is considered safe according to the European Food Safety Authority and FDA guidance. Daily consumption may pose risks for individuals with hypertension, anxiety disorders, arrhythmias, or gastritis, as caffeine stimulates cortisol release and gastric acid secretion. Pregnant individuals should cap daily caffeine intake at 200 mg, equivalent to roughly 1–2 cups, to minimize risk of restricted fetal growth.

### Can Myanmar Pyin Oo Lwin Coffee interact with medications?

Caffeine in this coffee is a potent inhibitor and substrate of the CYP1A2 enzyme, meaning it can raise plasma levels of drugs like theophylline and clozapine while having its own metabolism altered by CYP1A2 inducers such as rifampin or inhibitors such as fluvoxamine. Chlorogenic acids may mildly inhibit platelet aggregation, which could additively increase bleeding risk in patients on anticoagulants like warfarin or antiplatelet agents like clopidogrel. Patients taking diabetes medications including metformin or insulin should monitor blood glucose more closely, as the potential glucose-lowering effect of chlorogenic acids could increase hypoglycemia risk.

### Is Myanmar Pyin Oo Lwin Coffee safe during pregnancy and breastfeeding?

Myanmar Pyin Oo Lwin Coffee contains caffeine, which medical organizations recommend limiting to 200 mg per day during pregnancy due to potential miscarriage risks. Pregnant and breastfeeding individuals should consult a healthcare provider before consuming this or any caffeinated coffee, as caffeine passes into breast milk and may affect infant sleep and development.

### What is the clinical evidence specifically for Myanmar Pyin Oo Lwin Coffee as a supplement?

No clinical studies exist for this specific Myanmar cultivar variant. While standard Coffea arabica has research supporting antioxidant and chlorogenic acid content, these benefits cannot be verified as applying to the Pyin Oo Lwin cultivar without dedicated research on this particular strain.

### Who should avoid Myanmar Pyin Oo Lwin Coffee due to caffeine sensitivity?

Individuals with anxiety disorders, sleep disorders, arrhythmias, or uncontrolled high blood pressure should avoid or limit Myanmar Pyin Oo Lwin Coffee due to its caffeine content. Those with caffeine sensitivity, GERD, or IBS may experience digestive discomfort, and consultation with a healthcare provider is recommended before use.

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*Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com*
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