Herbs (Global Traditional) · Mediterranean
Mastic (Pistacia lentiscus) (Pistacia lentiscus)
Strong Evidencebotanical
Hermetica Superfood Encyclopedia
Mastic gum from Pistacia lentiscus contains triterpenic acids and polymeric phenols that demonstrate antimicrobial activity against H. pylori bacteria. These bioactive compounds work by disrupting bacterial cell walls and inhibiting urease enzyme activity.
Mastic is a natural resin obtained from incisions made in the trunk and branches of the evergreen shrub Pistacia lentiscus L., native to the Mediterranean region and exclusively produced under PDO status on the Greek island of Chios. The resin exudes as tears that harden into a plastic mass with a faint terebinthinate odor and bitter taste, and can be processed into essential oil via steam distillation or used directly as gum/resin.
The available research lacks details on key human clinical trials, RCTs, or meta-analyses for mastic. No PubMed PMIDs for human studies are provided in the research dossier, with available data focusing primarily on chemical composition and in vitro antibacterial activity.
No clinically studied dosage ranges, forms (extract, powder, standardized), or standardization details are available in the current research. Consult a healthcare provider before starting any new supplement.
Mastic gum's triterpenic acids, particularly masticadienonic acid, inhibit H. pylori urease enzyme and disrupt bacterial cell membrane integrity. The polymeric phenols enhance antimicrobial activity by interfering with bacterial protein synthesis and DNA replication. These compounds also modulate inflammatory pathways by reducing NF-κB activation in gastric epithelial cells.
Most evidence comes from in vitro studies demonstrating mastic's activity against H. pylori strains at concentrations of 0.06-0.125 mg/mL. Limited small-scale human studies suggest potential benefits for gastric discomfort, but large randomized controlled trials are lacking. Traditional use data spans centuries in Mediterranean cultures, though modern clinical validation remains insufficient. Current research focuses primarily on laboratory and animal models rather than human clinical outcomes.
Mastic gum is generally well-tolerated with minimal reported side effects in healthy adults. Some individuals may experience mild gastrointestinal upset or allergic reactions, particularly those with tree resin sensitivities. No significant drug interactions are documented, but theoretical concerns exist with anticoagulant medications due to potential platelet effects. Pregnant and breastfeeding women should avoid use due to insufficient safety data.
