Hermetica Superfood Encyclopedia
The Short Answer
Mahogany seed (Swietenia macrophylla) contains mahagonin (MSC15) which demonstrates antidiabetic activity by binding to protein tyrosine phosphatase 1B with -8.86 kcal/mol energy. The seed's phenolic compounds (70.83 mg GAE/g) and flavonoids provide antioxidant effects comparable to BHT and vitamin E through free radical scavenging mechanisms.
CategorySeed
GroupSeed
Evidence LevelStrong
Primary KeywordMahogany Seed benefits
Synergy Pairings4
Health Benefits
Supports liver detoxification by enhancing enzymatic pathways and protecting hepatocytes from damage.
Promotes cardiovascular wellness by modulating lipid profiles and supporting healthy circulation.
Aids blood sugar regulation through compounds that influence glucose metabolism and insulin sensitivity.
Enhances immune resilience with its rich content of saponins and flavonoids, fortifying natural defenses.
Supports digestive health by promoting a balanced gut environment and aiding nutrient absorption.
Contributes to cognitive function through its antioxidant and neuroprotective properties.
Modulates metabolic balance, supporting overall cellular efficiency and energy production.
Origin & History
Mahogany Seed, derived from the *Swietenia macrophylla* tree, is native to the tropical regions of Central and South America, Africa, and Southeast Asia. This revered botanical is known for its dense wood and its seeds, which are rich in bioactive compounds with significant functional properties.
“Revered in tropical indigenous traditions, Mahogany Seed has been used for centuries to promote vitality, resilience, and longevity. The seeds and trees symbolized protection and endurance, often incorporated into medicinal and ritual practices to fortify the body’s defenses and support overall well-being.”Traditional Medicine
Scientific Research
Emerging research, including in vitro and animal studies, supports Mahogany Seed's potential for liver detoxification, cardiovascular wellness, and blood sugar regulation. Studies highlight the hepatoprotective effects of its limonoids and the metabolic benefits of its diverse phytochemical profile, indicating promising therapeutic applications.
Preparation & Dosage
Common forms
Ground powder, decoctions, extracts, functional teas.
Traditional use
Ground into powders or decoctions for digestive, liver, and cardiovascular support; used in indigenous medicine for metabolic health and wound healing.
Modern use
Incorporated into supplements, functional teas, metabolic support blends, and nootropic formulations.
Recommended dosage
500–1000mg extract daily or 1–2g dried seeds steeped as a tea
Nutritional Profile
- Bioactives: Saponins, limonoids, flavonoids, phenolic acids
- Fiber: Dietary fiber
- Minerals: Potassium, magnesium, calcium, iron
- Vitamins: Small amounts of B vitamins (thiamine, riboflavin, niacin)
How It Works
Mechanism of Action
Mahagonin (MSC15) inhibits protein tyrosine phosphatase 1B via hydrogen bonds with GLU276 and ASN193 residues, mimicking glibenclamide's antidiabetic effects. Phenolic compounds totaling 70.83 mg GAE/g enable free radical scavenging through hydrogen donation and xanthine oxidase inhibition. The limonoid compounds enhance hepatic enzymatic pathways while saponins and flavonoids modulate immune and cardiovascular function.
Clinical Evidence
Evidence remains limited to preclinical studies with no human clinical trials reported. Animal studies show 79% reduction in carrageenan-induced inflammation at 1,000 mg/kg in mice and ~50% reduction in mitomycin C-induced cellular damage at 20 mg/kg. In vitro studies demonstrate cytotoxic effects against cancer cell lines (HCT116, MCF-7) at ≥0.05 mg/mL concentrations. Antimicrobial activity shows MIC/MBC values of 25-50 mg/mL against Staphylococcus aureus.
Safety & Interactions
Safety data is limited to preclinical studies showing low H₂O₂ cytotoxicity at doses under 20-50 mg, suggesting minimal cellular toxicity from phenolic compounds. High-dose cytotoxic effects observed in cancer cells include increased sub-G1 cell populations and glutathione depletion, indicating potential risks at elevated concentrations. No specific drug interactions or contraindications have been documented in available research. Pregnant and nursing women should avoid use due to insufficient safety data and potential cytotoxic effects.
Synergy Stack
Hermetica Formulation Heuristic
Fat + fiber base
Cardio & Circulation | Detox & Liver
Also Known As
Swietenia macrophyllaBig-leaf mahogany seedSwietenia mahagoniSky fruit seed
Frequently Asked Questions
What is the main active compound in mahogany seed?
Mahagonin (MSC15) is the primary bioactive compound, demonstrating the strongest protein binding activity at -8.86 kcal/mol against diabetes-related enzymes. The seeds also contain significant phenolic compounds at 70.83 mg GAE/g and flavonoids at 2.5 mg catechin equivalent/g.
How does mahogany seed help with diabetes?
Mahagonin inhibits protein tyrosine phosphatase 1B through hydrogen bonding, mimicking the mechanism of glibenclamide, a pharmaceutical diabetes medication. Animal studies suggest improved glucose metabolism and insulin sensitivity, though human clinical trials are not yet available.
Is mahogany seed safe to consume?
Safety data is limited to animal studies showing low toxicity at moderate doses under 20-50 mg. However, higher concentrations demonstrate cytotoxic effects in laboratory studies, and no human safety trials have been conducted.
What other health benefits does mahogany seed provide?
Preclinical studies show 79% anti-inflammatory activity in mice and antioxidant effects comparable to vitamin E and BHT. The seeds also demonstrate antimicrobial activity against bacteria like Staphylococcus aureus at 25-50 mg/mL concentrations.
Can mahogany seed interact with medications?
No specific drug interactions have been documented in available research, though the antidiabetic mechanism suggests potential interactions with diabetes medications. Consultation with healthcare providers is essential before combining with prescription drugs due to limited safety data.
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