# Luteolin from Celery **Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/luteolin-from-celery **Data Source:** Hermetica Superfoods Ingredient Encyclopedia **Updated:** 2026-03-15 **Evidence Score:** 4 / 10 **Category:** Compound **Also Known As:** Apium graveolens (Celery), Luteol ## Overview Luteolin, a potent flavonoid abundantly found in celery, is recognized for its strong antioxidant and [anti-inflammatory](/ingredients/condition/inflammation) properties. Its unique chemical structure enables it to neutralize [free radical](/ingredients/condition/antioxidant)s and inhibit cellular damage, supporting overall health. ## Health Benefits - Neutralizes free radicals, providing robust [antioxidant protection](/ingredients/condition/antioxidant) and supporting cellular health. - Inhibits [inflammatory pathway](/ingredients/condition/inflammation)s, benefiting joint health and modulating chronic inflammatory responses. - Enhances neuroprotection and may support [cognitive function](/ingredients/condition/cognitive) by reducing neuroinflammation. - Improves blood vessel function and helps reduce cholesterol levels, promoting [cardiovascular health](/ingredients/condition/heart-health). - Regulates immune responses, supporting resilience against infections and modulating autoimmune conditions. - Demonstrates preliminary anti-cancer potential by inhibiting tumor growth in in vitro and animal models. ## Mechanism of Action Luteolin's strong [antioxidant activity](/ingredients/condition/antioxidant) stems from hydroxyl groups at the 5, 7, 3′, and 4′ carbon positions, enabling efficient free radical neutralization. A carbonyl oxygen at the 4 position and a double bond between carbons 2 and 3 contribute to its biocidal and [antimicrobial](/ingredients/condition/immune-support) effects. Furthermore, luteolin inhibits LPC-induced endothelial cell apoptosis by blocking calcium influx, calpain activity, and cytochrome C release within the [mitochondrial](/ingredients/condition/energy) pathway. ## Clinical Summary Extensive scientific research, including in vitro and animal studies, supports luteolin's potent [antioxidant](/ingredients/condition/antioxidant) and [anti-inflammatory](/ingredients/condition/inflammation) properties. These studies indicate significant therapeutic potential in neuroprotection, [cardiovascular health](/ingredients/condition/heart-health), and [immune modulation](/ingredients/condition/immune-support). While some human clinical trials exist, the majority of evidence comes from preclinical models, highlighting the need for further large-scale human studies to fully elucidate its clinical efficacy and optimal dosing. ## Nutritional Profile - Flavonoid: Luteolin (a flavone) - [Antioxidant Activity](/ingredients/condition/antioxidant): Neutralizes free radicals and protects against cellular damage. - Anti-Inflammatory Effects: Modulates [inflammatory pathway](/ingredients/condition/inflammation)s to reduce chronic inflammation. - [Neuroprotective](/ingredients/condition/cognitive) Properties: Supports brain function and protects against neurodegenerative processes. - Phytochemicals: Contributes to blood sugar regulation and [skin health](/ingredients/condition/skin-health) by reducing oxidative damage. ## Dosage & Preparation - Common forms: Celery extracts, concentrated supplements (capsule or powder), or consumed via fresh celery. - Culinary Use: Consume fresh celery raw or in smoothies to maximize natural luteolin intake. - Supplements: Available as concentrated luteolin in capsule or powder form for targeted benefits. - Recommended Dosage: A typical daily dose ranges from 20–50 mg of luteolin extract, depending on health goals. ## Safety & Drug Interactions The provided research does not detail specific side effects, drug interactions, contraindications, or safety during pregnancy for luteolin from celery. As a naturally occurring flavonoid, it is generally considered safe when consumed as part of a balanced diet. However, for concentrated supplement forms, it is advisable to consult a healthcare professional, especially for pregnant or breastfeeding individuals or those on medication. ## Scientific Research Extensive scientific research, including in vitro, animal studies, and some human clinical trials, supports luteolin's potent [antioxidant](/ingredients/condition/antioxidant) and [anti-inflammatory](/ingredients/condition/inflammation) properties. Studies have explored its [neuroprotective](/ingredients/condition/cognitive), [cardiovascular](/ingredients/condition/heart-health), and immune-modulating effects, indicating significant therapeutic potential. While promising, further robust human clinical trials are needed to fully establish specific health claims and optimal dosages. ## Historical & Cultural Context While Luteolin itself is a modern biochemical isolate, its source, celery, has a rich history in traditional medicine. Celery (Apium graveolens) has been utilized for centuries in Ayurvedic and Traditional Chinese Medicine for its [anti-inflammatory](/ingredients/condition/inflammation) and digestive properties, treating conditions like hypertension and arthritis. This traditional wisdom now finds validation through modern scientific understanding of compounds like luteolin. ## Synergistic Combinations Role: Polyphenol/[antioxidant](/ingredients/condition/antioxidant) base Intention: Immune & [Inflammation](/ingredients/condition/inflammation) | Cognition & Focus Primary Pairings: - Turmeric (Curcuma longa) - Vitamin C (Ascorbic Acid) - Quercetin (flavonoid) - Omega-3 Fatty Acids (DHA) ## Frequently Asked Questions ### What is luteolin and what are its primary benefits? Luteolin is a potent flavonoid abundant in celery and other plants, known for its strong antioxidant and anti-inflammatory properties. It helps neutralize free radicals, supports cellular health, inhibits inflammatory pathways, and may enhance neuroprotection. ### Which parts of celery contain luteolin? Luteolin is found throughout the celery plant, including its leaves, petioles (stalks), and seeds. White celery leaves, for example, can contain significant amounts, with studies reporting concentrations such as 36 μg/g. ### How does luteolin provide antioxidant protection? Luteolin's strong antioxidant activity is attributed to its chemical structure, specifically the hydroxyl groups at the 5, 7, 3′, and 4′ carbon positions. These groups enable it to efficiently scavenge and neutralize free radicals, thereby protecting cells from oxidative damage. ### What are luteolin's mechanisms for anti-inflammatory and neuroprotective effects? Luteolin inhibits inflammatory pathways and reduces neuroinflammation, supporting brain health. It also inhibits LPC-induced endothelial cell apoptosis by modulating the calcium-dependent mitochondrial pathway, blocking calcium influx, calpain activity, and cytochrome C release. ### What is the current scientific evidence supporting luteolin's health benefits? Extensive scientific research, primarily through in vitro and animal studies, supports luteolin's potent antioxidant, anti-inflammatory, neuroprotective, cardiovascular, and immune-modulating effects. While some human clinical trials exist, further large-scale human studies are needed to confirm its full therapeutic potential. ### Does luteolin from celery interact with blood pressure or cholesterol medications? Luteolin may have additive effects with blood pressure-lowering and cholesterol-reducing medications due to its cardiovascular benefits, potentially enhancing their effects. If you are taking antihypertensive or statin medications, consult your healthcare provider before supplementing with luteolin to avoid over-correction or adverse interactions. Medical supervision is particularly important if you are on warfarin or other anticoagulants, as luteolin's bioactive properties may affect bleeding risk. ### Is celery-derived luteolin safe for pregnant women or nursing mothers? There is limited clinical safety data on luteolin supplementation during pregnancy and lactation, so it is generally recommended to avoid concentrated supplements during these periods. While celery is a safe food, concentrated luteolin extracts may deliver levels exceeding normal dietary intake and have not been adequately studied in pregnant or nursing populations. Consult your obstetrician or midwife before using luteolin supplements if you are pregnant or breastfeeding. ### How much luteolin from celery do I need to consume daily for health benefits? Clinical studies examining luteolin's benefits have typically used doses ranging from 50–100 mg daily, though optimal dosage varies depending on the specific health goal and individual absorption. A typical serving of fresh celery contains approximately 2.6–12 mg of luteolin, meaning dietary sources alone may not achieve therapeutic levels observed in research. Supplemental luteolin extracts are often standardized to provide consistent dosing, but individual needs should be confirmed with a healthcare practitioner. ## References Research links: https://www.ncbi.nlm.nih.gov/search/all/?term=Luteolin+from+Celery | Studies: https://pubmed.ncbi.nlm.nih.gov/?term=Luteolin+from+Celery --- *Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com* *License: CC BY-NC-SA 4.0 — Attribution required. Commercial use: admin@hermeticasuperfoods.com*