Hermetica Superfood Encyclopedia
The Short Answer
Luteolin is a plant compound found in celery that acts as a powerful antioxidant and anti-inflammatory agent, with emerging research on brain and heart health benefits.
CategoryVegetable
GroupCompound
Evidence LevelModerate
Synergy Pairings4
Health Benefits
Neutralizes free radicals, providing robust antioxidant protection and supporting cellular health.
Inhibits inflammatory pathways, benefiting joint health and modulating chronic inflammatory responses.
Enhances neuroprotection and may support cognitive function by reducing neuroinflammation.
Improves blood vessel function and helps reduce cholesterol levels, promoting cardiovascular health.
Regulates immune responses, supporting resilience against infections and modulating autoimmune conditions.
Demonstrates preliminary anti-cancer potential by inhibiting tumor growth in in vitro and animal models.
Origin & History
Luteolin is a potent flavonoid, abundantly found in celery (Apium graveolens) and other plant-based foods like parsley and thyme. While celery is native to the Mediterranean region, luteolin itself is a widely distributed plant compound. It is extensively studied for its significant antioxidant and anti-inflammatory properties, making it a valuable bioactive for therapeutic and functional nutrition applications.
“While Luteolin itself is a modern biochemical isolate, its source, celery, has a rich history in traditional medicine. Celery (Apium graveolens) has been utilized for centuries in Ayurvedic and Traditional Chinese Medicine for its anti-inflammatory and digestive properties, treating conditions like hypertension and arthritis. This traditional wisdom now finds validation through modern scientific understanding of compounds like luteolin.”Traditional Medicine
Scientific Research
Extensive scientific research, including in vitro, animal studies, and some human clinical trials, supports luteolin's potent antioxidant and anti-inflammatory properties. Studies have explored its neuroprotective, cardiovascular, and immune-modulating effects, indicating significant therapeutic potential. While promising, further robust human clinical trials are needed to fully establish specific health claims and optimal dosages.
Preparation & Dosage
Common forms
Celery extracts, concentrated supplements (capsule or powder), or consumed via fresh celery.
Culinary Use
Consume fresh celery raw or in smoothies to maximize natural luteolin intake.
Supplements
Available as concentrated luteolin in capsule or powder form for targeted benefits.
Recommended Dosage
20–50 mg of luteolin extract, depending on health goals
A typical daily dose ranges from .
Nutritional Profile
- Flavonoid: Luteolin (a flavone)
- Antioxidant Activity: Neutralizes free radicals and protects against cellular damage.
- Anti-Inflammatory Effects: Modulates inflammatory pathways to reduce chronic inflammation.
- Neuroprotective Properties: Supports brain function and protects against neurodegenerative processes.
- Phytochemicals: Contributes to blood sugar regulation and skin health by reducing oxidative damage.
Synergy Stack
Hermetica Formulation Heuristic
Polyphenol/antioxidant base
Immune & Inflammation | Cognition & Focus
Frequently Asked Questions
What is luteolin from celery?
Luteolin is a flavone — a type of flavonoid antioxidant — found naturally in celery, parsley, thyme, and other plants. It is studied for its potent anti-inflammatory and neuroprotective properties, working by inhibiting key inflammatory pathways including NF-kB and pro-inflammatory cytokines.
What is the recommended dosage of luteolin and is it safe?
Typical supplemental dosages range from 20-50 mg daily of luteolin extract. While generally well-tolerated, human safety data at high doses is limited. Individuals on blood-thinning medications or drugs metabolized by CYP1A2 or CYP3A4 enzymes should consult a healthcare provider before supplementing.
How does luteolin compare to other anti-inflammatory flavonoids like quercetin?
Luteolin and quercetin share similar anti-inflammatory mechanisms, but luteolin has shown stronger inhibition of certain inflammatory markers like TNF-alpha and IL-6 in some in vitro studies. However, quercetin has more extensive human clinical trial data. Luteolin may be particularly promising for neuroinflammation, though more human research is needed to confirm this advantage.
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