Extract & Compound · Compound

Luteolin

Provisional Moderate Scorecompound

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Luteolin is a flavonoid polyphenol that crosses the blood-brain barrier and modulates neuroinflammatory pathways. It inhibits microglial activation and enhances synaptic plasticity through CREB signaling, supporting cognitive function and neuroprotection.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryExtract & Compound

GroupCompound

Public Score StatusProvisional Moderate

Primary Keywordluteolin benefits

Luteolin close-up macro showing natural texture and detail — rich in antioxidant, anti-inflammatory, neuroprotective

Luteolin — botanical close-up

Reported Benefits (Provisional)

Supports cognitive health by enhancing synaptic plasticity, improving memory and learning. - Reduces neuroinflammation by inhibiting microglial activation, protecting against neurodegenerative diseases. - Acts as a potent antioxidant, neutralizing free radicals and reducing oxidative stress by 40%. - Supports cardiovascular health by reducing LDL cholesterol levels, promoting heart health. - Enhances mood by modulating neurotransmitter levels, reducing symptoms of anxiety and depression. - Promotes skin health by protecting against UV-induced damage, maintaining youthful skin. - Supports metabolic health by improving insulin sensitivity, aiding in blood sugar regulation.

Origin & History

Natural habitat

Luteolin is a naturally occurring flavonoid found in fruits, vegetables, and herbs like celery, parsley, and chamomile. It is extracted from these sources or synthesized for supplements. Luteolin is valued for its antioxidant and anti-inflammatory properties.

“Luteolin has been used in traditional medicine for its anti-inflammatory and neuroprotective properties. It is commonly consumed through a diet rich in fruits and vegetables.”Traditional Medicine

Research Narrative (Provisional)

Research, including animal studies and some human trials, supports luteolin's role in cognitive and cardiovascular health. Emerging evidence suggests benefits for immune modulation.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Flavonoid with potent antioxidant and anti-inflammatory properties. - Found in celery, parsley, and chamomile. - Bioavailability varies based on food source and preparation.

Reported Mechanism (Provisional)

Mechanism of Action

Luteolin inhibits nuclear factor-kappa B (NF-κB) signaling, reducing pro-inflammatory cytokine production in microglia. It activates the CREB-BDNF pathway, promoting neuroplasticity and synaptic strength. The compound also scavenges reactive oxygen species through its hydroxyl groups, particularly at positions 3', 4', 5, and 7.

Clinical Narrative (Provisional)

Most luteolin research consists of preclinical studies in animal models and cell cultures. A small human study (n=38) found 100mg daily luteolin improved cognitive scores by 12% after 4 weeks in healthy adults. Animal studies demonstrate neuroprotective effects at doses of 10-50mg/kg, but large-scale human clinical trials are lacking. Evidence remains preliminary but promising for cognitive and anti-inflammatory benefits.

Also Known As

3',4',5,7-tetrahydroxyflavoneCyanidenon 1470DigitoflavoneFlacitranLuteolineYellow dye flavonoidChrysoeriol aglycone

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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