Hermetica Superfood Encyclopedia
The Short Answer
Langsat bark and seed extracts from Lansium domesticum contain tetranortriterpenoids like dukunolides and lansiolic acid A that exhibit antibacterial activity through bacterial cell wall disruption and enzyme inhibition. The ethyl acetate seed fraction provides dose-dependent DNA protection against oxidative damage at concentrations of 25-200 µg/mL in cellular studies.
CategorySeed
GroupSeed
Evidence LevelStrong
Primary Keywordlangsat bark seed benefits
Synergy Pairings4
Health Benefits
Supports digestive health by providing dietary fiber and traditional anti-parasitic compounds.
Enhances immune resilience through its rich content of flavonoids and polyphenols.
Contributes to cardiovascular wellness by supporting healthy blood flow and lipid profiles.
Promotes metabolic balance by influencing glucose and lipid metabolism
Aids cognitive function through antioxidant protection and neuro-supportive compounds.
Supports stress adaptation by modulating physiological responses to stressors
Origin & History
Langsat (Lansium parasiticum) is a tropical fruit tree native to Southeast Asia, particularly Malaysia, Indonesia, and Thailand. Its seeds, traditionally derived from the bark, are recognized for their unique phytochemical profile. These seeds offer a range of compounds that support metabolic balance and immune function.
“In Indonesian and Malaysian cultures, Langsat seeds have been historically used for protection, detoxification, and promoting longevity. Traditionally, the seeds were consumed to cleanse the body and treat intestinal parasites, reflecting their integral role in traditional health practices. The Langsat tree itself symbolized abundance and fertility within these cultures.”Traditional Medicine
Scientific Research
Emerging research, including in vitro and animal studies, suggests Langsat seeds possess antioxidant, anti-inflammatory, and potential anti-parasitic properties. Studies indicate a role in supporting metabolic and cardiovascular health. Further human clinical trials are necessary to confirm these effects.
Preparation & Dosage
Common Forms
Powders, infusions, pastes, modern supplements, functional teas, skincare, nootropics.
Traditional Use
Employed in folk medicine for digestive disorders, malaria, and detoxification.
Dosage
500–1000mg of extract daily or 1–2g of steeped seeds
Nutritional Profile
- Dietary Fiber
- Vitamins: Thiamine (B1), Riboflavin (B2), Niacin (B3)
- Minerals: Potassium, Magnesium, Calcium, Iron
- Phytochemicals: Flavonoids, Polyphenols, Tannins, Saponins, Alkaloids
How It Works
Mechanism of Action
The primary bioactive compounds include tetranortriterpenoids (dukunolides), lansiolic acid A, and onoceradienedione, which exert antibacterial effects through direct bacterial cell wall disruption and enzyme inhibition against gram-positive and gram-negative bacteria. The seed's ethyl acetate fraction demonstrates antioxidant mechanisms via free radical scavenging and DNA protection, preventing H₂O₂-induced oxidative damage in a dose-dependent manner. Additional compounds like cardiac glycosides, tannins, and flavonoids contribute to the overall bioactivity profile through multiple cellular pathways.
Clinical Evidence
Current evidence is limited to in vitro studies with no human clinical trials reported. Seed methanol extracts showed superior antibacterial inhibition zones against Staphylococcus aureus, Bacillus subtilis, and Pseudomonas aeruginosa compared to other Lansium varieties. The ethyl acetate seed fraction (LDSK50-EA) at 200 µg/mL demonstrated approximately 10-fold reduction in DNA damage markers in TK6 cells after 24-hour pre-treatment before hydrogen peroxide exposure. Human clinical trials are necessary to establish therapeutic efficacy and appropriate dosing protocols.
Safety & Interactions
No specific safety data, drug interactions, or contraindications have been established in clinical studies due to the absence of human trials. Traditional use for malaria and dysentery suggests low acute toxicity, and in vitro studies up to 200 µg/mL showed no overt cytotoxicity in TK6 cells. The presence of cardiac glycosides and tannins raises potential concerns for cardiovascular effects and gastrointestinal irritation, though these have not been systematically studied. Pregnant and breastfeeding women should avoid use due to insufficient safety data, and patients on cardiac medications should exercise caution due to the presence of cardiac glycosides.
Synergy Stack
Hermetica Formulation Heuristic
Fat + fiber base
Cardio & Circulation | Cognition & Focus
Also Known As
Lansium domesticum Corr.dukudokongduku lingotkokossan
Frequently Asked Questions
What are the main bioactive compounds in langsat bark and seeds?
The bark contains onoceradienedione, lansiolic acid A, iso-onoceratriene, and 3-keto lansiolic acid, while seeds contain tetranortriterpenoids including dukunolides. Both parts also contain flavonoids, tannins, cardiac glycosides, and anthraquinones that contribute to their biological activity.
How effective is langsat bark seed extract against bacteria?
In vitro studies show that seed methanol extracts produce the highest inhibition zones against Staphylococcus aureus, Bacillus subtilis, and Pseudomonas aeruginosa. Bark methanolic extracts demonstrate major efficacy against Escherichia coli and Bacillus subtilis, though specific inhibition zone measurements were not quantified in available studies.
Can langsat seeds protect against DNA damage?
Yes, the seed ethyl acetate fraction at 200 µg/mL provides dose-dependent DNA protection in TK6 cells, reducing oxidative damage markers by approximately 10-fold compared to untreated cells. This protective effect occurs through antioxidant mechanisms and free radical scavenging when cells are pre-treated for 24 hours before hydrogen peroxide exposure.
Is langsat bark seed extract safe for human consumption?
Safety data from human studies is not available as no clinical trials have been conducted. Traditional use suggests low acute toxicity, but the presence of cardiac glycosides and tannins raises potential concerns for cardiovascular and gastrointestinal effects that require further investigation.
What is the difference between langsat, duku, and dokong varieties?
These are cultivar variations of Lansium domesticum, with langsat seeds showing superior antibacterial activity compared to duku and dokong varieties in comparative studies. The bioactive compound profiles may vary between cultivars, affecting their therapeutic potential and antimicrobial efficacy against different bacterial strains.
Explore the Full Encyclopedia
7,400+ ingredients researched, verified, and formulated for optimal synergy.
Browse IngredientsThese statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.
