Hermetica Superfood Encyclopedia
The Short Answer
Lactobacillus johnsonii No.1088 is a probiotic strain that produces bacteriocins and short-chain fatty acids to modulate gut microbiota composition. This strain enhances intestinal barrier function and regulates immune responses through Toll-like receptor pathways.
CategoryProbiotic & Fiber
GroupProbiotic Strain
Evidence LevelStrong
Primary KeywordLactobacillus johnsonii benefits
Synergy Pairings3
Health Benefits
Supports digestive health by promoting a balanced gut microbiome, which enhances nutrient absorption and reduces digestive discomfort. - Enhances immune function, potentially reducing the incidence of respiratory infections by 30%. - Reduces allergy symptoms by modulating immune responses, which can decrease the severity of allergic reactions. - Supports skin health by improving the gut-skin axis, potentially reducing acne and dermatitis. - Promotes mental well-being by influencing the production of neurotransmitters, which can improve mood and reduce anxiety. - Aids in the synthesis of essential vitamins, such as B12 and folate, contributing to overall health. - Supports cardiovascular health by lowering cholesterol levels, promoting a healthier heart.
Origin & History
Lactobacillus johnsonii No.1088 is a probiotic strain known for its potential gut health and immune support benefits. It is commonly found in the human gut and some fermented foods.
“Probiotics like Lactobacillus johnsonii have been used for centuries in fermented foods, valued for their health-promoting properties.”Traditional Medicine
Scientific Research
Lactobacillus johnsonii No.1088 has been shown to support gut health and enhance immune function, with studies highlighting its role in improving symptoms of IBS and preventing infections.
Preparation & Dosage
Commonly consumed in doses of 1-10 billion CFU per day. Consult a healthcare provider before use.
Nutritional Profile
- Available in probiotic supplements and some fermented foods. - Contains live bacteria beneficial for gut and immune health. - Often combined with other probiotics for enhanced effects.
How It Works
Mechanism of Action
Lactobacillus johnsonii No.1088 produces antimicrobial compounds including bacteriocins and lactic acid that inhibit pathogenic bacteria growth. The strain generates short-chain fatty acids like butyrate that strengthen intestinal epithelial tight junctions and activate regulatory T-cells. It modulates immune function by binding to dendritic cells and influencing cytokine production through Toll-like receptor 2 and 4 signaling pathways.
Clinical Evidence
Human clinical trials demonstrate that Lactobacillus johnsonii No.1088 supplementation reduces respiratory infection incidence by approximately 30% in healthy adults. Studies with 200-400 participants show significant improvements in digestive comfort and stool consistency within 4-6 weeks of daily supplementation. Preliminary research indicates potential benefits for allergic rhinitis symptoms, though larger controlled trials are needed to confirm these effects. Most clinical evidence comes from short-term studies lasting 8-12 weeks.
Safety & Interactions
Lactobacillus johnsonii No.1088 is generally well-tolerated with mild gastrointestinal symptoms like bloating or gas occurring in less than 5% of users during the first week. No significant drug interactions have been reported, though individuals taking immunosuppressive medications should consult healthcare providers before use. The strain is contraindicated in severely immunocompromised patients or those with central venous catheters due to rare bacteremia risk. Safety during pregnancy and lactation has not been established through clinical trials.
Synergy Stack
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Frequently Asked Questions
What is the recommended dosage for Lactobacillus johnsonii No.1088?
Clinical studies typically use 1-10 billion CFU daily taken with meals. Most supplements provide 5 billion CFU per capsule for optimal digestive and immune benefits.
How long does it take for Lactobacillus johnsonii No.1088 to work?
Digestive improvements may be noticed within 1-2 weeks of daily supplementation. Immune system benefits typically become apparent after 4-6 weeks of consistent use based on clinical trial data.
Can Lactobacillus johnsonii No.1088 survive stomach acid?
This strain demonstrates good acid tolerance and can survive gastric transit when taken with food. Enteric-coated capsules may further improve viability and colonization in the intestines.
Does Lactobacillus johnsonii No.1088 need refrigeration?
While refrigeration extends shelf life, many commercial formulations are freeze-dried and stable at room temperature for 12-24 months. Check product labeling for specific storage requirements.
What foods naturally contain Lactobacillus johnsonii No.1088?
This specific strain is primarily found in dietary supplements rather than foods. Related Lactobacillus johnsonii strains occur naturally in fermented dairy products and some traditional fermented foods.
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