# Lactobacillus casei DN-114001

**Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/lactobacillus-casei-dn-114001
**Data Source:** Hermetica Superfoods Ingredient Encyclopedia
**Updated:** 2026-03-18
**Evidence Score:** 8 / 10
**Category:** Other
**Also Known As:** Lactobacillus casei DN-114001, L. casei DN-114001, Lactobacillus casei Shirota strain, Actimel strain, Danone probiotic strain, LC DN-114001, Immunitas strain

## Overview

Lactobacillus casei DN-114001 is a clinically studied [probiotic](/ingredients/condition/gut-health) strain that produces bacteriocins and lactic acid to inhibit pathogenic bacteria. It modulates gut microbiota composition and enhances intestinal barrier function through tight junction protein regulation.

## Health Benefits

- Supports [digestive health](/ingredients/condition/gut-health) by balancing gut microbiota, reducing symptoms of IBS by up to 50% according to studies. It enhances nutrient absorption by optimizing the gut environment. - Enhances immune response by stimulating the production of antibodies, which helps reduce the duration of colds by 30%. It fortifies the body's defense against pathogens. - Reduces [inflammation](/ingredients/condition/inflammation) by modulating cytokine production, which can alleviate symptoms of inflammatory bowel diseases. It promotes overall gut health and comfort. - Improves lactose digestion by producing lactase, making dairy more tolerable for lactose-intolerant individuals. It allows for a more diverse diet. - Boosts mood by increasing [serotonin](/ingredients/condition/mood) levels, as 90% of serotonin is produced in the gut. It contributes to mental well-being and stress reduction. - Aids in weight management by influencing the hormones that regulate appetite, potentially reducing caloric intake. It supports a healthy [metabolism](/ingredients/condition/weight-management). - Enhances [skin health](/ingredients/condition/skin-health) by reducing [oxidative stress](/ingredients/condition/antioxidant), which can decrease acne severity. It promotes a clearer, more radiant complexion.

## Mechanism of Action

This strain produces bacteriocins and lactic acid that create an acidic environment hostile to pathogenic bacteria while promoting beneficial microflora growth. It stimulates dendritic cells in Peyer's patches, activating T-helper cells and increasing IgA antibody production. The strain also strengthens intestinal barrier function by upregulating claudin-1 and occludin tight junction proteins.

## Clinical Summary

Randomized controlled trials with 200-400 participants demonstrate that Lactobacillus casei DN-114001 reduces IBS symptom severity by up to 50% over 4-8 week periods. Studies show significant improvements in abdominal pain scores and bowel movement frequency. [Immune function](/ingredients/condition/immune-support) trials indicate reduced cold duration, though sample sizes remain modest at 100-200 subjects. Evidence quality is moderate with most studies being industry-funded.

## Nutritional Profile

- Present in [probiotic](/ingredients/condition/gut-health) supplements and dairy products. - Contains beneficial live bacteria that support gut health. - Often combined with other probiotic strains for enhanced effects.

## Dosage & Preparation

Commonly consumed in doses of 1-10 billion CFU per day. Consult a healthcare provider before use.

## Safety & Drug Interactions

Lactobacillus casei DN-114001 is generally well-tolerated with mild gastrointestinal side effects like bloating occurring in less than 5% of users. It may theoretically reduce effectiveness of antibiotics when taken simultaneously due to bacterial competition. Immunocompromised individuals should consult healthcare providers before use due to rare risk of bacteremia. Safety during pregnancy and lactation has not been established through clinical trials.

## Scientific Research

Studies have shown Lactobacillus casei DN-114001 to be effective in supporting gut health and enhancing [immune function](/ingredients/condition/immune-support), with evidence supporting its role in alleviating gastrointestinal issues.

## Historical & Cultural Context

[Probiotic](/ingredients/condition/gut-health)-rich foods have been a staple in many cultures, with Lactobacillus casei strains playing a key role in the fermentation of dairy products.

## Synergistic Combinations

Bifidobacterium, Yogurt, [Prebiotic](/ingredients/condition/gut-health)s, Lactose, Gut microbiota

## Frequently Asked Questions

### What is the recommended dosage of Lactobacillus casei DN-114001?

Clinical studies typically use doses of 10^8 to 10^10 CFU (colony forming units) daily. Most commercial supplements provide 1-10 billion CFU per serving, taken with or without food for optimal colonization.

### How long does it take for Lactobacillus casei DN-114001 to work?

Initial gut colonization occurs within 3-7 days of supplementation. Digestive benefits like reduced IBS symptoms typically appear after 2-4 weeks of consistent use, while immune benefits may take 4-6 weeks to manifest.

### Can Lactobacillus casei DN-114001 survive stomach acid?

This strain demonstrates good acid tolerance with 60-80% survival rates at pH 2.0 for 2 hours. Its natural resistance to gastric conditions allows effective colonization of the small and large intestines without requiring enteric coating.

### Is Lactobacillus casei DN-114001 the same as regular Lactobacillus casei?

No, DN-114001 is a specific strain with unique genetic markers and proven clinical efficacy. While all L. casei strains share basic characteristics, DN-114001 has distinct adhesion properties and immune-modulating capabilities documented in human trials.

### What foods naturally contain Lactobacillus casei DN-114001?

This specific strain is not found naturally in foods but is added to certain fermented dairy products like Actimel/DanActive yogurt drinks. Most dietary sources require targeted supplementation rather than relying on traditional fermented foods like kefir or yogurt.

### Is Lactobacillus casei DN-114001 safe to take with antibiotics?

Lactobacillus casei DN-114001 can be taken with antibiotics, but timing matters—it's best to separate them by at least 2 hours to prevent the antibiotic from killing the beneficial bacteria. Some research suggests taking probiotics during antibiotic courses may reduce antibiotic-associated diarrhea by up to 60%. Consult your healthcare provider about the optimal timing for your specific antibiotic regimen.

### Who benefits most from Lactobacillus casei DN-114001 supplementation?

People with irritable bowel syndrome (IBS), weakened immune systems, or those recovering from infections or antibiotic use benefit most from this strain. It is also beneficial for individuals with poor digestive health, frequent colds, or chronic inflammation-related conditions. Healthy individuals may use it preventatively to maintain gut balance and immune resilience.

### What clinical evidence supports the effectiveness of Lactobacillus casei DN-114001?

Multiple peer-reviewed studies demonstrate that Lactobacillus casei DN-114001 reduces IBS symptoms by up to 50% and shortens cold duration by approximately 30% through immune stimulation. Clinical trials show it improves bowel regularity and reduces bloating within 2–4 weeks of consistent use. The strain is well-researched with decades of safety data from its use in functional foods like yogurt and fermented beverages.

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*Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com*
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