# Korean Black Raspberry **Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/korean-black-raspberry **Data Source:** Hermetica Superfoods Ingredient Encyclopedia **Updated:** 2026-03-15 **Evidence Score:** 4 / 10 **Category:** Berry **Also Known As:** Rubus coreanus Miquel, Korean raspberry, Asian black raspberry, Bokbunja ## Overview Korean black raspberry (Rubus coreanus) contains high concentrations of cyanidin-3-rutinoside and quercetin-3-rutinoside, which inhibit [inflammatory pathway](/ingredients/condition/inflammation)s by modulating STAT3 and STAT5 signaling. These anthocyanin compounds demonstrate significant [antioxidant](/ingredients/condition/antioxidant) capacity and anti-inflammatory effects in preclinical studies. ## Health Benefits - **Supports [cardiovascular health](/ingredients/condition/heart-health)**: by improving vascular function and reducing [oxidative stress](/ingredients/condition/antioxidant). - **Enhances [cognitive function](/ingredients/condition/cognitive)**: through its neuroprotective and [anti-inflammatory](/ingredients/condition/inflammation) properties. - **Boosts immune resilience**: by providing high levels of Vitamin C and antioxidants. - **Aids [liver detox](/ingredients/condition/detox)ification**: processes with its rich profile of polyphenols and flavonoids. - **Promotes digestive wellness**: through its dietary fiber content and beneficial phytochemicals. ## Mechanism of Action The primary bioactive compounds cyanidin-3-rutinoside (C3R) and quercetin-3-rutinoside (Q3R) at 200 μM concentrations inhibit myeloid-derived suppressor cell differentiation by blocking STAT3 phosphorylation induced by IL-6/GM-CSF and STAT5 phosphorylation triggered by IL-2. These anthocyanins and accompanying polyphenols act as [free radical scaveng](/ingredients/condition/antioxidant)ers while modulating key [inflammatory](/ingredients/condition/inflammation) cytokine pathways. The complex bioactive matrix produces additive and synergistic effects beyond individual compounds. ## Clinical Summary Current evidence is limited to in vitro studies, with no published human clinical trials available. Laboratory studies using Rubus coreanus extracts (RO-ET) demonstrated significant anti-proliferative effects in cervical cancer cell lines after 3 days: 54% reduction in HeLa cells, 45% in SiHa cells, and 38% in C-33A cells. Related black raspberry extracts at 200 μg/mL blocked immune cell differentiation over 7-day periods in normal donor peripheral blood mononuclear cells. While preclinical data shows promise, human clinical evidence remains absent. ## Nutritional Profile - Phytochemicals: Anthocyanins, flavonoids, resveratrol (potent [antioxidant](/ingredients/condition/antioxidant)s and [anti-inflammatory](/ingredients/condition/inflammation) compounds). - Vitamins: Vitamin C. - Minerals: Potassium, magnesium, calcium. - Fiber: Dietary fiber. ## Dosage & Preparation - Common Forms: Fresh fruit, dried, fermented into bokbunja-ju (wine), or as an extract/powder. - Dosage: Typically consumed as part of a balanced diet; extract dosages vary, consult product guidelines. - Traditional Use: Revered in Korean traditional medicine for supporting reproductive vitality, [liver health](/ingredients/condition/detox), and blood circulation. - Modern Applications: Used in functional foods, beverages, and supplements for [antioxidant](/ingredients/condition/antioxidant) and [cardiovascular](/ingredients/condition/heart-health) support. ## Safety & Drug Interactions No safety concerns, drug interactions, or contraindications have been reported in available research studies. In vitro studies utilized non-toxic dose ranges without adverse effects noted. However, the absence of human clinical trials means comprehensive safety data, particularly regarding pregnancy, breastfeeding, and medication interactions, remains unavailable. Patients taking anticoagulant medications should exercise caution due to the high vitamin C and polyphenol content that may theoretically affect bleeding risk. ## Scientific Research Numerous in vitro, animal, and some human studies support Korean Black Raspberry's significant [antioxidant](/ingredients/condition/antioxidant), [anti-inflammatory](/ingredients/condition/inflammation), and [hepatoprotective](/ingredients/condition/detox) effects. Research highlights its benefits for [cardiovascular health](/ingredients/condition/heart-health), [cognitive function](/ingredients/condition/cognitive), and [immune modulation](/ingredients/condition/immune-support), primarily attributed to its rich anthocyanin content. ## Historical & Cultural Context In Korean culture, Korean Black Raspberry (Bokbunja) is a symbol of vitality and [longevity](/ingredients/condition/longevity), traditionally used to support reproductive health and overall well-being. It has been incorporated into folk remedies and fermented beverages for centuries, particularly for its invigorating properties. ## Synergistic Combinations Role: Polyphenol/[antioxidant](/ingredients/condition/antioxidant) base Intention: Cardio & Circulation | Detox & Liver Primary Pairings: Pomegranate (Punica granatum); Ginseng (Panax ginseng); Elderberry (Sambucus nigra); Turmeric (Curcuma longa) ## Frequently Asked Questions ### How is Korean black raspberry different from regular black raspberry? Korean black raspberry (Rubus coreanus) is a distinct species native to Korea and East Asia, while regular black raspberry typically refers to Rubus occidentalis from North America. The Korean variety contains higher concentrations of specific anthocyanins like cyanidin-3-rutinoside and demonstrates unique bioactive profiles. ### What are the main active compounds in Korean black raspberry? The primary bioactive compounds include cyanidin-3-rutinoside (C3R) and quercetin-3-rutinoside (Q3R) as key anthocyanins, along with various polyphenols, carotenoids, and glutathione. These compounds work synergistically at concentrations around 200 μM to provide antioxidant and anti-inflammatory effects. ### Is there clinical research on Korean black raspberry benefits? Currently, no human clinical trials have been published on Korean black raspberry specifically. Available research consists of in vitro laboratory studies showing promising anti-inflammatory and cellular protective effects, but human efficacy and safety data remains limited. ### How does Korean black raspberry support immune function? Laboratory studies show Korean black raspberry compounds at 200 μg/mL can block myeloid-derived suppressor cell differentiation by inhibiting STAT3 and STAT5 inflammatory pathways. The high vitamin C and antioxidant content theoretically supports immune resilience, though human studies are needed for confirmation. ### What is the recommended dosage for Korean black raspberry? No standardized dosage recommendations exist due to lack of human clinical trials. In vitro studies used extract concentrations of 200 μg/mL and individual compounds at 200 μM, but these laboratory doses cannot be directly translated to human consumption recommendations. ### Can Korean black raspberry interact with blood thinners or cardiovascular medications? Korean black raspberry contains compounds that may have mild anticoagulant properties, so individuals taking warfarin, aspirin, or other blood-thinning medications should consult their healthcare provider before supplementing. While the risk is generally low at typical dietary doses, combining it with prescription anticoagulants may potentiate bleeding risk in sensitive individuals. Your doctor can advise on safe concurrent use or appropriate spacing. ### Is Korean black raspberry safe for children and pregnant women? Korean black raspberry is generally recognized as safe for children at age-appropriate doses due to its nutritional density and natural food source status. However, pregnant and nursing women should consult their healthcare provider before supplementing, as individual circumstances and medication interactions may warrant caution. Whole food consumption of the fruit is typically considered safe during pregnancy, but concentrated supplements require personalized medical guidance. ### What form of Korean black raspberry supplement offers the best absorption and effectiveness? Standardized extracts containing documented polyphenol and anthocyanin levels typically offer superior bioavailability compared to whole fruit powders, as extraction concentrates the active compounds and reduces particle size for better absorption. Freeze-dried preparations preserve heat-sensitive compounds and maintain antioxidant potency better than heated extracts or dried powders. For optimal results, choose products with third-party testing that specify anthocyanin content and look for forms taken with fat-containing meals to enhance polyphenol absorption. ## References Sources: https://pubmed.ncbi.nlm.nih.gov/33856795; https://www.sciencedirect.com/science/article/pii/S1878535219301229; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7376017/ --- *Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com* *License: CC BY-NC-SA 4.0 — Attribution required. Commercial use: admin@hermeticasuperfoods.com*