Extract & Compound · Compound

Kaempferol

Provisional Moderate Scorecompound

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Kaempferol is a flavonoid polyphenol that enhances nitric oxide synthase activity to support cardiovascular health and blood flow. This bioactive compound demonstrates potent antioxidant properties through its ability to scavenge free radicals and inhibit lipid peroxidation.

—

Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryExtract & Compound

GroupCompound

Public Score StatusProvisional Moderate

Primary Keywordkaempferol benefits

Kaempferol close-up macro showing natural texture and detail — rich in antioxidant, anti-inflammatory, antimicrobial

Kaempferol — botanical close-up

Reported Benefits (Provisional)

Supports cardiovascular health by enhancing nitric oxide production, improving blood flow. - Acts as a powerful antioxidant, reducing oxidative stress and protecting against cellular damage. - Reduces inflammation by inhibiting pro-inflammatory cytokines, alleviating chronic conditions. - Supports bone health by promoting osteoblast activity, increasing bone density. - Enhances metabolic health by improving insulin sensitivity, aiding in weight management. - Promotes liver health by reducing fat accumulation, preventing liver disease. - Supports respiratory health by reducing airway inflammation, improving lung function.

Origin & History

Natural habitat

Kaempferol is a naturally occurring flavonoid found in fruits, vegetables, and herbs like kale, tea, and broccoli. It is extracted from these sources or synthesized for supplements. Kaempferol is valued for its antioxidant and anti-inflammatory properties.

“Kaempferol has been used in traditional medicine for its anti-inflammatory and cardioprotective properties. It is commonly consumed through a diet rich in fruits and vegetables.”Traditional Medicine

Research Narrative (Provisional)

Research, including animal studies and some human trials, supports kaempferol's role in cardiovascular and cognitive health. Emerging evidence suggests benefits for immune modulation.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Flavonoid with potent antioxidant and anti-inflammatory properties. - Found in kale, tea, and broccoli. - Bioavailability varies based on food source and preparation.

Reported Mechanism (Provisional)

Mechanism of Action

Kaempferol activates endothelial nitric oxide synthase (eNOS) to increase nitric oxide production, promoting vasodilation and improved blood flow. It inhibits nuclear factor-kappa B (NF-κB) signaling pathways, reducing pro-inflammatory cytokines like TNF-α and IL-6. The compound also upregulates antioxidant enzymes including superoxide dismutase and catalase while chelating metal ions that catalyze oxidative reactions.

Clinical Narrative (Provisional)

Human studies on kaempferol are limited, with most evidence derived from in vitro and animal research. A 12-week study in 60 adults showed kaempferol-rich extract (50mg daily) improved endothelial function by 15% compared to placebo. Animal studies demonstrate significant anti-inflammatory effects at doses of 10-50mg/kg body weight. More randomized controlled trials are needed to establish definitive therapeutic benefits and optimal dosing in humans.

Also Known As

3,5,7-trihydroxy-2-(4-hydroxyphenyl)-4H-chromen-4-oneKaempferol 3-glucosideRobigeninPelargidenolonIndigo YellowNimbecetin

Browse All Ingredients More Compound About the Encyclopedia

These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

From the Hermetica Research Desk

Research updates — and 25% off your first order

Join our list for source-aware wellness education, review-state updates, and product news — and unlock 25% off your first Hermetica order. Educational content is not medical advice. No spam, unsubscribe anytime.

Educational content only — not medical advice.