# Jaceosidin

**Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/jaceosidin
**Data Source:** Hermetica Superfoods Ingredient Encyclopedia
**Updated:** 2026-03-29
**Evidence Score:** 2 / 10
**Category:** Compound
**Also Known As:** 5,7-dihydroxy-6,4'-dimethoxyflavone, Artemisia flavone, Chinese mugwort flavonoid, Folium Artemisiae Argyi extract compound, A. princeps flavone, Traditional Chinese medicine flavonoid

## Overview

Jaceosidin is a polymethoxylated flavonoid found primarily in Artemisia and Saussurea plant species that exerts its biological effects by modulating NF-κB signaling, inducing [mitochondrial](/ingredients/condition/energy) apoptosis, and suppressing [pro-inflammatory cytokine](/ingredients/condition/inflammation) cascades. Research in animal and cell-based models suggests it holds potential in oncology, neuroprotection, and cardioprotection, though no human clinical trials have been completed.

## Health Benefits

• May reduce inflammation and microglial activation in spinal cord injury (preliminary evidence from mouse studies) • Supports cardiac function during sepsis-induced myocardial dysfunction (animal model evidence only) • Shows anti-cancer properties against gastric cancer cells, inducing apoptosis at 39 μM concentration (in vitro evidence) • Demonstrates [neuroprotective effect](/ingredients/condition/cognitive)s through PKM2 enzyme inhibition (preclinical evidence) • Exhibits [antioxidant activity](/ingredients/condition/antioxidant) through modulation of [inflammatory pathway](/ingredients/condition/inflammation)s (cell culture studies)

## Mechanism of Action

Jaceosidin inhibits the NF-κB signaling pathway by preventing IκBα phosphorylation and degradation, thereby reducing transcription of pro-[inflammatory](/ingredients/condition/inflammation) genes encoding TNF-α, IL-1β, and IL-6. In cancer cells, it triggers intrinsic [mitochondrial](/ingredients/condition/energy) apoptosis by downregulating anti-apoptotic Bcl-2 and Bcl-xL proteins while upregulating pro-apoptotic Bax, leading to cytochrome c release and caspase-3/9 activation. It also inhibits microglial activation partly through suppression of iNOS and COX-2 enzyme expression.

## Clinical Summary

All available evidence for jaceosidin comes from in vitro cell studies and in vivo mouse or rat models, with zero published human clinical trials to date. In a mouse model of spinal cord injury, jaceosidin reduced lesion-site microglial activation and [inflammatory](/ingredients/condition/inflammation) cytokine levels, improving functional recovery scores. Rat models of sepsis-induced myocardial dysfunction showed jaceosidin administration attenuated cardiac troponin I release and improved ejection fraction metrics. Gastric cancer cell line studies (e.g., SGC-7901, MKN-45) demonstrated dose-dependent apoptosis induction at micromolar concentrations (typically 10–80 µM), but translation to human dosing remains entirely speculative.

## Nutritional Profile

Jaceosidin is a pure bioactive flavonoid compound (specifically a flavone), not a whole food or nutritional ingredient, and therefore has no macronutrient, micronutrient, fiber, or protein content in the conventional dietary sense. Molecular formula: C17H14O7, molecular weight: 334.28 g/mol. It is classified as a polymethoxylated flavone with the following structural features: hydroxyl groups at positions 4', 5, and 7; methoxy groups at positions 3', 4' (partial), and 6. Bioactive compound identity: 5,7-dihydroxy-3',4',6-trimethoxyflavone. Natural sources include Artemisia argyi, Artemisia iwayomogi, and related Artemisia species (mugwort family), where it occurs at trace concentrations typically in the range of 0.01–0.5% dry weight of plant material depending on species and extraction method. Bioavailability is considered limited due to its hydrophobic methoxy groups, suggesting poor aqueous solubility; lipid-based delivery or nanoformulation may enhance absorption. No established dietary reference intake (DRI) or recommended daily allowance (RDA) exists. The compound is studied exclusively in research contexts at concentrations of 10–100 μM in vitro (e.g., 39 μM demonstrated apoptotic effects in gastric cancer cells) and at mg/kg doses in animal models. It is not present in meaningful nutritional quantities in typical human diets.

## Dosage & Preparation

No clinically studied human dosages are available. In cell culture studies, concentrations of 20-100 μM have been used, with an IC50 of approximately 39 μM in gastric cancer cells. Animal studies used unspecified doses via injection or culture medium. Consult a healthcare provider before starting any new supplement.

## Safety & Drug Interactions

No human safety data, established tolerable upper limits, or pharmacokinetic profiles in humans currently exist for jaceosidin. Because it suppresses [NF-κB](/ingredients/condition/inflammation) and modulates cytochrome P450 activity in preclinical models, it may theoretically interact with immunosuppressants, anticoagulants such as warfarin, and chemotherapy agents metabolized via CYP3A4. Pregnant and breastfeeding individuals should avoid jaceosidin entirely due to the absence of reproductive safety data and its botanical origin in Artemisia species, which contain compounds with uterotonic potential. Individuals with autoimmune conditions or those on corticosteroids should consult a physician before considering any jaceosidin-containing product.

## Scientific Research

No human clinical trials have been conducted with jaceosidin; all evidence comes from preclinical studies. Key research includes a mouse spinal cord injury model showing reduced microglial activation (PMC12325413), a murine sepsis-induced myocardial dysfunction model demonstrating improved cardiac function (PMID: 41599696), and gastric cancer cell studies showing 40% increased apoptosis at 39 μM concentration (PMC10854459).

## Historical & Cultural Context

Jaceosidin is derived from Artemisia species that have been used for centuries in traditional Chinese medicine formulations for inflammation and injury. These plants, particularly A. princeps and Folium Artemisiae Argyi, are valued for their [anti-inflammatory](/ingredients/condition/inflammation), [antioxidant](/ingredients/condition/antioxidant), and [neuroprotective](/ingredients/condition/cognitive) properties in TCM.

## Synergistic Combinations

Other flavonoids, quercetin, curcumin, resveratrol, green tea polyphenols

## Frequently Asked Questions

### What plant is jaceosidin found in naturally?

Jaceosidin is found predominantly in plants of the Artemisia genus, including Artemisia argyi and Artemisia capillaris, as well as in Saussurea species within the Asteraceae family. These plants have a long history of use in traditional East Asian medicine, and jaceosidin is considered one of their bioactive polymethoxylated flavonoid constituents.

### Does jaceosidin kill cancer cells?

In laboratory cell studies, jaceosidin has induced apoptosis in gastric cancer cell lines such as SGC-7901 at concentrations of approximately 10–80 µM by activating the intrinsic mitochondrial pathway via Bax upregulation and Bcl-2 suppression. However, these are in vitro findings, and no human trials exist, meaning anti-cancer effects in living humans are unproven and cannot be claimed.

### How does jaceosidin reduce inflammation?

Jaceosidin reduces inflammation primarily by blocking NF-κB pathway activation, specifically preventing the phosphorylation of IκBα, which keeps NF-κB sequestered in the cytoplasm and unable to drive transcription of cytokines like TNF-α and IL-6. It also downregulates iNOS and COX-2 enzyme activity, reducing nitric oxide and prostaglandin E2 production in activated immune cells.

### Is jaceosidin safe to take as a supplement?

Jaceosidin has no established human safety profile, no FDA-recognized dosage, and no completed clinical trials assessing tolerability or adverse effects in people. Preclinical data suggest potential interactions with CYP3A4-metabolized drugs and immunosuppressants, making its use risky without medical supervision, particularly for individuals on prescription medications.

### What is the difference between jaceosidin and other Artemisia flavonoids like artemetin?

Jaceosidin (5,7-dihydroxy-3',4',6-trimethoxyflavone) and artemetin (3,5,7-trihydroxy-3',4',6-trimethoxyflavone) are both polymethoxylated flavones from Artemisia species but differ in their hydroxylation patterns, which affects receptor binding affinity and biological potency. Jaceosidin notably retains a free 5-OH group that is associated with stronger COX-2 inhibition, while artemetin shows comparatively greater activity at the cannabinoid CB2 receptor in preliminary studies.

### What does the current clinical evidence show about jaceosidin's effectiveness in humans?

Most evidence for jaceosidin comes from laboratory and animal studies, with limited human clinical trials published to date. The strongest data exists for its anti-inflammatory and neuroprotective mechanisms in preclinical models, particularly regarding spinal cord injury and cardiac function during sepsis. More human-based research is needed to establish efficacy, dosing, and safety profiles for supplement use.

### Does jaceosidin have better bioavailability in certain forms or when taken with food?

As a flavonoid, jaceosidin's absorption may be enhanced when consumed with dietary fats or alongside other compounds that support flavonoid bioavailability, though specific bioavailability studies on jaceosidin supplements are limited. Most naturally occurring jaceosidin is found in plant matrix form (such as Artemisia herba alba extracts) which may influence absorption compared to isolated supplements. Taking jaceosidin-containing products with meals is generally recommended to optimize absorption, though individual absorption can vary significantly.

### Who might benefit most from jaceosidin supplementation based on current research?

Individuals interested in neuroprotection, spinal cord health support, and anti-inflammatory benefits may be candidates, based on promising animal model data, though clinical evidence in humans remains preliminary. Those concerned with gastric health or seeking complementary approaches to cancer prevention may be interested in jaceosidin's in vitro anti-cancer properties, though these effects have not been demonstrated in human studies. Anyone considering jaceosidin should consult a healthcare provider, as research is still emerging and individual suitability depends on personal health status.

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