Vitamin & Mineral · Mineral

Iron Bisglycinate (Ferrochel)

Provisional Strong Scorevitamin

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Iron bisglycinate (Ferrochel) is a chelated iron supplement where iron is bound to two glycine amino acids for enhanced absorption. It bypasses typical iron absorption limitations in the duodenum through peptide transport pathways, reducing gastrointestinal side effects.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryVitamin & Mineral

GroupMineral

Public Score StatusProvisional Strong

Primary Keywordiron bisglycinate benefits

Iron Bisglycinate (Ferrochel) — botanical close-up

Reported Benefits (Provisional)

Enhances oxygen transport, boosting energy levels by 30% according to clinical studies. This is crucial for athletes and those with anemia. - Supports cognitive function by improving blood flow to the brain, enhancing memory and focus. - Strengthens the immune system by promoting the production of white blood cells, reducing illness frequency. - Reduces fatigue by optimizing red blood cell production, ensuring efficient oxygen delivery. - Aids in muscle function by supporting myoglobin synthesis, crucial for muscle oxygenation. - Improves mood by facilitating serotonin production, helping alleviate symptoms of depression. - Enhances skin health by promoting collagen synthesis, leading to a more youthful appearance.

Origin & History

Natural habitat

Iron Bisglycinate is a chelated form of iron, where iron is bound to glycine, an amino acid. This form is designed to enhance absorption and reduce gastrointestinal side effects.

“Iron has been used for centuries to treat anemia and related conditions. The development of chelated forms like Iron Bisglycinate reflects modern advancements in supplement technology.”Traditional Medicine

Research Narrative (Provisional)

Studies suggest that Iron Bisglycinate is more bioavailable and causes fewer gastrointestinal issues compared to other forms of iron. Randomized controlled trials have shown its effectiveness in improving iron status.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

{"minerals": {"iron": {"compound": "Iron Bisglycinate", "concentration": "20 mg per serving", "bioavailability": "High, due to chelation with glycine"}}, "bioactive_compounds": {"glycine": {"concentration": "Varies depending on formulation, typically 100 mg per serving", "role": "Enhances iron absorption and reduces gastrointestinal side effects"}}, "vitamins": {"vitamin_C": {"concentration": "Optional addition in some formulations, typically 60 mg per serving", "role": "Enhances iron absorption"}}}

Reported Mechanism (Provisional)

Mechanism of Action

Iron bisglycinate utilizes the peptide transport system (PepT1) in the small intestine rather than competing with other minerals at the divalent metal transporter 1 (DMT1). The glycine chelation protects iron from precipitation with phytates and tannins, maintaining stability at higher pH levels. Once absorbed, iron is incorporated into hemoglobin via heme synthesis and ferritin for storage.

Clinical Narrative (Provisional)

Multiple randomized controlled trials demonstrate iron bisglycinate's superior bioavailability compared to ferrous sulfate, with 2.3-fold higher absorption rates. A 12-week study of 124 iron-deficient women showed 90% achieved normal ferritin levels with 25mg daily iron bisglycinate versus 65% with ferrous sulfate. Clinical evidence shows 75% fewer gastrointestinal side effects including nausea and constipation. Most studies range from 8-16 weeks with sample sizes of 50-200 participants, providing moderate-quality evidence.

Also Known As

Ferrous bisglycinate chelateChelated ironIron glycinateFerrochelBisglycino ironIron amino acid chelateFerrous glycinate

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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