# Hydrastine **Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/hydrastine **Data Source:** Hermetica Superfoods Ingredient Encyclopedia **Updated:** 2026-03-19 **Evidence Score:** 4 / 10 **Category:** Compound **Also Known As:** (S)-Hydrastine, β-Hydrastine, L-Hydrastine, Hydrastine alkaloid, Goldenseal alkaloid, 6,7-Methylenedioxy-1-[(3,4-methylenedioxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline-1-carboxylic acid methyl ester ## Overview Hydrastine is an isoquinoline alkaloid found in goldenseal root that has been studied primarily for its chemical properties rather than therapeutic effects. No clinical trials have documented health benefits in humans, with evidence limited to traditional use contexts only. ## Health Benefits • No clinical health benefits documented - no human trials identified in available research • Traditional use context only through goldenseal preparations (evidence quality: traditional only) • Chemical properties studied but no pharmacological effects documented (evidence quality: none) • Safety profile not established through clinical research (evidence quality: insufficient) • Mechanism of action unknown - no receptor or enzyme interactions identified (evidence quality: none) ## Mechanism of Action Hydrastine exhibits weak [antimicrobial](/ingredients/condition/immune-support) activity through interaction with bacterial cell membrane components, though specific receptor targets remain poorly characterized. The compound may influence calcium channel activity and smooth muscle contraction in laboratory studies. However, these mechanisms have not been validated in human clinical research or shown to produce therapeutic effects. ## Clinical Summary No randomized controlled trials or clinical studies have evaluated hydrastine's health effects in humans. Available research consists primarily of in vitro chemical analysis and traditional use documentation through goldenseal preparations. Laboratory studies have examined [antimicrobial](/ingredients/condition/immune-support) properties but failed to demonstrate clinically relevant potency. The evidence base remains insufficient to support any health claims for this alkaloid. ## Nutritional Profile Hydrastine is an isoquinoline alkaloid (molecular formula C₂₁H₂₁NO₆, MW ~383.4 g/mol) found primarily in goldenseal (Hydrastis canadensis) root, typically comprising 1.5–4% of dried root weight alongside berberine (~2–6%) and canadine. It is not a nutrient and has no macronutrient, vitamin, or mineral content. As a bioactive alkaloid, it undergoes hepatic [metabolism](/ingredients/condition/weight-management) and has limited oral bioavailability due to first-pass effects. It exists as two diastereomers (α-hydrastine and β-hydrastine), with β-hydrastine being the predominant natural form. The compound is poorly water-soluble but soluble in ethanol and chloroform. No established RDA, tolerable upper intake, or standardized dosing exists. It should be regarded strictly as a phytochemical of research interest, not a nutritional compound. ## Dosage & Preparation No clinically studied dosage ranges for hydrastine are available. The compound typically comprises 1-4% of goldenseal root extracts, but no human dosing data from trials exists. Consult a healthcare provider before starting any new supplement. ## Safety & Drug Interactions Safety data for isolated hydrastine is extremely limited due to lack of human studies. Potential concerns may mirror those of goldenseal, including possible interactions with cytochrome P450 enzymes and [blood pressure](/ingredients/condition/heart-health) medications. High doses may cause gastrointestinal irritation or cardiovascular effects based on alkaloid class properties. Pregnant and breastfeeding women should avoid due to insufficient safety data. ## Scientific Research No human clinical trials, RCTs, or meta-analyses specifically on hydrastine were identified in the available research. The compound has been studied primarily for its chemical properties rather than clinical applications, with goldenseal (containing 1-4% hydrastine) nominated for toxicity evaluation but no specific trial data available. ## Historical & Cultural Context Hydrastine occurs in Hydrastis canadensis (goldenseal), historically used in Native American traditional medicine. However, specific traditional uses for hydrastine versus other goldenseal alkaloids like berberine are not documented in available sources. ## Synergistic Combinations Hydrastine naturally co-occurs with berberine and canadine in goldenseal root, and these three isoquinoline alkaloids may have complementary mechanisms—berberine targets NF-κB and AMPK pathways while hydrastine may contribute vasoconstrictive and smooth-muscle effects, potentially enhancing the overall [antimicrobial](/ingredients/condition/immune-support) and [anti-inflammatory](/ingredients/condition/inflammation) profile of whole goldenseal extracts. Echinacea purpurea alkylamides (particularly isobutylamides from Echinacea) are traditionally paired with goldenseal alkaloids in immune-support formulations, as the immunostimulatory action of echinacea may complement the antimicrobial alkaloid activity. Additionally, piperine (5–10 mg from black pepper extract) may enhance the oral bioavailability of hydrastine and co-occurring berberine by inhibiting CYP3A4 and P-glycoprotein efflux, similar to its well-documented effect of increasing berberine plasma concentrations by approximately 2-fold. Note: These synergies are theoretical or based on traditional formulation practices, not validated in clinical trials specific to isolated hydrastine. ## Frequently Asked Questions ### What foods contain hydrastine naturally Hydrastine is found exclusively in goldenseal root (Hydrastis canadensis) and is not present in common foods. The alkaloid comprises approximately 0.5-6% of goldenseal root depending on extraction methods and plant maturity. ### Is hydrastine the same as berberine No, hydrastine and berberine are different alkaloids though both occur in goldenseal. Berberine has extensive clinical research showing metabolic benefits, while hydrastine lacks human studies and documented therapeutic effects. ### What is the typical dosage of hydrastine supplements No standardized dosage exists for hydrastine as it is not sold as an isolated supplement. Goldenseal products containing hydrastine typically provide 250-500mg of whole root extract, but hydrastine content varies significantly. ### Can hydrastine help with infections Laboratory studies show weak antimicrobial activity, but no clinical trials demonstrate infection-fighting benefits in humans. The antimicrobial potency appears insufficient for therapeutic use compared to established treatments. ### Are there any proven health benefits of hydrastine No clinical health benefits have been proven for hydrastine in human studies. All available evidence comes from traditional use contexts and basic chemical research without therapeutic validation. ### What does current research say about hydrastine's safety profile? Clinical safety data for hydrastine is insufficient, as no controlled human trials have been conducted to establish safety parameters. The available evidence is limited to traditional use through goldenseal preparations and in vitro studies. Anyone considering hydrastine supplementation should consult a healthcare provider, particularly those with existing health conditions or taking medications. ### Does hydrastine interact with common medications? Specific drug interaction data for hydrastine has not been established through clinical research. However, as an alkaloid compound found in goldenseal, it may potentially affect liver metabolism similarly to other alkaloids, though this requires further study. Individuals taking prescription medications should consult their healthcare provider before using hydrastine supplements. ### Who should avoid taking hydrastine supplements? Due to insufficient safety data, hydrastine is not recommended for pregnant women, nursing mothers, or young children without medical supervision. People with liver conditions, autoimmune disorders, or those taking medications metabolized by the liver should also avoid hydrastine until safety is better established. Always consult a healthcare professional before use, especially if you have underlying health conditions. --- *Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com* *License: CC BY-NC-SA 4.0 — Attribution required. Commercial use: admin@hermeticasuperfoods.com*