# Gotu Kola (Centella asiatica)

**Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/gotu-kola
**Data Source:** Hermetica Superfoods Ingredient Encyclopedia
**Updated:** 2026-03-19
**Evidence Score:** 6 / 10
**Category:** Ayurveda
**Also Known As:** Centella asiatica, Indian pennywort, Asiatic pennywort, Brahmi, Mandukaparni, Tiger grass, Thankuni, Pegaga

## Overview

Gotu kola (Centella asiatica) contains bioactive triterpenes including asiaticoside, asiatic acid, and madecassoside that may support wound healing and [cognitive function](/ingredients/condition/cognitive). The herb works primarily by modulating [collagen synthesis](/ingredients/condition/skin-health) and potentially affecting neurotransmitter pathways.

## Health Benefits

• Limited clinical evidence available - research dossier lacks specific human trial data
• Traditional use in Ayurveda and Traditional Chinese Medicine for various conditions (evidence quality: traditional only)
• Contains bioactive triterpenes with noted pharmacological activity (evidence quality: preliminary)
• Bioavailability studies show distribution to brain, stomach, and skin tissues (evidence quality: preliminary pharmacokinetic data)
• Approximately 124 compounds identified including asiaticoside and madecassoside (evidence quality: chemical analysis only)

## Mechanism of Action

Gotu kola's triterpenes, particularly asiaticoside and asiatic acid, stimulate collagen synthesis by increasing fibroblast activity and enhancing type I [collagen production](/ingredients/condition/skin-health). These compounds may also modulate GABA neurotransmission and reduce neuroinflammation through inhibition of [pro-inflammatory cytokine](/ingredients/condition/inflammation)s. Additionally, the herb appears to strengthen venous walls by promoting glycosaminoglycan synthesis in blood vessel connective tissue.

## Clinical Summary

Human studies on gotu kola are limited but show some promise for venous insufficiency and wound healing. A few small trials (20-100 participants) suggest 60-120mg daily may improve venous circulation and reduce ankle swelling. [Cognitive](/ingredients/condition/cognitive) studies are primarily animal-based, with minimal human data available. The overall clinical evidence remains insufficient to establish definitive therapeutic benefits, requiring larger, well-controlled trials.

## Nutritional Profile

Gotu Kola (Centella asiatica) is a non-caloric medicinal herb used primarily for its bioactive phytochemical content rather than macronutrient value. Key bioactive compounds include: Triterpenoid saponins (primary actives) - asiaticoside (approximately 0.1–0.9% dry weight), madecassoside (approximately 0.3–1.0% dry weight), asiatic acid (approximately 0.5–1.0% dry weight), and madecassic acid (approximately 0.3–0.7% dry weight); these four compounds collectively constitute the 'total triterpenic fraction of Centella asiatica' (TTFCA), typically standardized to 40% in commercial extracts. Flavonoids present include quercetin, kaempferol, and rutin at trace concentrations (0.01–0.05% dry weight). Polyacetylenes including centellicin are present in small amounts. Macronutrients per 100g fresh leaf: crude protein approximately 2.3–3.0g, crude fiber approximately 1.8–2.5g, carbohydrates approximately 4.5–6.0g, fat less than 0.5g. Micronutrients include vitamin C (approximately 48–70mg/100g fresh weight), vitamin B2/riboflavin (trace), calcium (approximately 171mg/100g), iron (approximately 3.1mg/100g), and potassium (approximately 391mg/100g). Bioavailability notes: Triterpenes show moderate oral bioavailability with Tmax of 2–4 hours post-ingestion; distribution studies confirm tissue-level uptake in brain, skin, and gastric mucosa. Asiaticoside undergoes hydrolysis to asiatic acid in the gut, which is considered the primary absorbed form. Lipid-based delivery systems and phospholipid complexes have shown enhanced bioavailability in preliminary studies. Chlorogenic acid derivatives and hydroxycinnamic acids are also present as minor phenolic constituents.

## Dosage & Preparation

No clinically studied dosage ranges for different forms (extract, powder, standardized) are specified in the available research. Standardization details from studies are not provided. Consult a healthcare provider before starting any new supplement.

## Safety & Drug Interactions

Gotu kola is generally well-tolerated but may cause skin irritation, headaches, or stomach upset in sensitive individuals. It may potentiate sedative medications due to potential GABA activity and could theoretically interact with anticoagulants. Pregnant and nursing women should avoid use due to insufficient safety data. Individuals with liver disease should exercise caution, as rare cases of hepatotoxicity have been reported with high doses.

## Scientific Research

The research dossier does not provide specific human clinical trials, RCTs, or meta-analyses with PMIDs. While general pharmacological activity is attributed to triterpenes, no factual clinical trial data including study designs, sample sizes, or outcomes is available in the current sources.

## Historical & Cultural Context

Gotu Kola has been used in traditional medicine systems including Ayurveda and Traditional Chinese Medicine for various diseases. However, specific conditions treated, duration of use, or detailed historical contexts are not provided in the available sources.

## Synergistic Combinations

Insufficient research data to recommend synergistic combinations

## Known Interactions

| Substance | Severity | Summary | URL |
|---|---|---|---|
| Memantine | SAFE | 🟢 SAFE — Gotu Kola and Memantine can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/memantine |
| Tribulus Terrestris | SAFE | 🟢 SAFE — Gotu Kola and Tribulus Terrestris can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/tribulus-terrestris |
| Hawthorn Berry | SAFE | 🟢 SAFE — Gotu Kola and Hawthorn Berry can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/hawthorn-berry |
| Olive Leaf Extract | SAFE | 🟢 SAFE — Gotu Kola and Olive Leaf Extract can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/olive-leaf-extract |
| Oregano Oil | SAFE | 🟢 SAFE — Gotu Kola and Oregano Oil can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/oregano-oil |
| Garlic Extract | SAFE | 🟢 SAFE — Gotu Kola and Garlic Extract can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/garlic-extract |
| Cinnamon Extract | SAFE | 🟢 SAFE — Gotu Kola and Cinnamon Extract can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/cinnamon-extract |
| Cayenne | SAFE | 🟢 SAFE — Gotu Kola and Cayenne can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/cayenne |
| Dandelion Root | SAFE | 🟢 SAFE — Gotu Kola and Dandelion Root can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/dandelion-root |
| Nettle Root | SAFE | 🟢 SAFE — Gotu Kola and Nettle Root can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/nettle-root |
| Pine Bark Extract | SAFE | 🟢 SAFE — Gotu Kola and Pine Bark Extract can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/pine-bark-extract |
| Grape Seed Extract | SAFE | 🟢 SAFE — Gotu Kola and Grape Seed Extract can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/grape-seed-extract |
| BCAAs | SAFE | 🟢 SAFE — Gotu Kola and BCAAs can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/bcaas |
| L-Glutamine | SAFE | 🟢 SAFE — Gotu Kola and L-Glutamine can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/l-glutamine |
| L-Arginine | SAFE | 🟢 SAFE — Gotu Kola and L-Arginine can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/l-arginine |
| L-Carnosine | SAFE | 🟢 SAFE — Gotu Kola and L-Carnosine can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/l-carnosine |
| HMB | SAFE | 🟢 SAFE — Gotu Kola and HMB can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/hmb |
| D-Aspartic Acid | SAFE | 🟢 SAFE — Gotu Kola and D-Aspartic Acid can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/d-aspartic-acid |
| Electrolyte Complex | SAFE | 🟢 SAFE — Gotu Kola and Electrolyte Complex can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/electrolyte-complex |
| Whey Protein | SAFE | 🟢 SAFE — Gotu Kola and Whey Protein can be taken together safely. | https://ingredients.hermeticasuperfoods.com/interactions/whey-protein |

## Frequently Asked Questions

### What is the typical dosage of gotu kola extract?

Clinical studies typically use 60-120mg daily of standardized extract containing 40% asiaticoside. Traditional preparations may use 1-2 grams of dried herb three times daily, though standardized extracts provide more consistent triterpene content.

### How long does gotu kola take to show effects?

For venous circulation benefits, improvements may be noticed within 2-4 weeks of consistent use. Wound healing applications may show results in 1-2 weeks, while any cognitive effects would likely require 4-8 weeks of supplementation.

### Can gotu kola cause liver damage?

Rare cases of hepatotoxicity have been reported, primarily with high doses or contaminated products. Most users experience no liver issues, but individuals with existing liver conditions should consult healthcare providers before use.

### Is gotu kola the same as kola nut?

No, gotu kola (Centella asiatica) is completely different from kola nut (Cola nitida). Gotu kola contains no caffeine and is an herb used for circulation and wound healing, while kola nut is a caffeine-containing seed.

### Does gotu kola interact with blood thinning medications?

Gotu kola may theoretically enhance anticoagulant effects due to its influence on circulation and potential anti-platelet activity. Individuals taking warfarin, aspirin, or other blood thinners should consult their physician before combining with gotu kola supplements.

### What does clinical research show about gotu kola's effectiveness?

Clinical evidence for gotu kola remains limited, with most traditional uses supported by historical practice in Ayurveda and Traditional Chinese Medicine rather than rigorous human trials. While preliminary laboratory studies have identified bioactive triterpenes with potential pharmacological activity, larger-scale human studies are needed to confirm efficacy for specific health claims. Current research primarily demonstrates safety and tissue distribution patterns rather than definitive therapeutic outcomes.

### Is gotu kola safe during pregnancy and breastfeeding?

Gotu kola safety during pregnancy and breastfeeding has not been extensively studied in clinical trials, making it difficult to provide definitive recommendations. Traditional use suggests low toxicity, but the lack of specific human safety data means pregnant or nursing women should consult a healthcare provider before supplementing. Caution is warranted given the ingredient's distribution to multiple body tissues and the sensitivity of fetal and infant development.

### Which form of gotu kola has the best absorption—extract, powder, or fresh leaf?

Standardized extracts typically offer superior bioavailability compared to whole powder, as extraction concentrates the bioactive triterpenes and improves their distribution to brain, stomach, and skin tissues. Fresh leaf contains active compounds but provides inconsistent potency and lower concentrations than processed forms. Bioavailability studies favor extract formulations, though absorption can vary based on individual factors like digestive health and whether the supplement is taken with food.

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*Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com*
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