Oil & Fat · Other

GLA (Gamma-Linolenic Acid)

Provisional Strong Scorelipid

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

GLA (gamma-linolenic acid) is an omega-6 fatty acid that converts to dihomo-gamma-linolenic acid (DGLA) and anti-inflammatory prostaglandins. It regulates inflammatory responses and maintains skin barrier function through prostaglandin E1 synthesis.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryOil & Fat

GroupOther

Public Score StatusProvisional Strong

Primary KeywordGLA benefits

GLA close-up macro showing natural texture and detail — rich in anti-inflammatory, immunomodulatory, skin-protective

GLA (Gamma-Linolenic Acid) — botanical close-up

Reported Benefits (Provisional)

Supports skin health by improving hydration and reducing inflammation

GLA increases skin moisture by 25%, combating dryness. - Aids in managing symptoms of eczema and psoriasis. It reduces skin inflammation, alleviating discomfort and redness. - Supports hormonal balance, particularly in women. GLA aids in the synthesis of prostaglandins, regulating menstrual cycles. - Enhances joint health by reducing stiffness and pain. Its anti-inflammatory effects improve mobility and comfort. - Boosts hair health and growth. GLA nourishes hair follicles, promoting thicker and healthier hair. - Supports weight management by enhancing fat metabolism. It aids in breaking down stored fat for energy. - May improve nerve function. GLA supports myelin sheath health, crucial for nerve transmission.

Origin & History

Natural habitat

GLA, or gamma-linolenic acid, is an omega-6 fatty acid found in plant oils such as evening primrose oil and borage oil. It is extracted through cold-pressing to preserve its nutritional integrity.

“GLA has been used traditionally in herbal medicine for its anti-inflammatory properties and benefits for women's health, particularly in managing menstrual symptoms.”Traditional Medicine

Research Narrative (Provisional)

Several human trials have shown GLA's benefits in supporting skin and joint health. Its role in managing PMS symptoms is also supported by research.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Rich in omega-6 fatty acids, particularly GLA. - Found in plant-based sources like evening primrose and borage oil. - Often used in combination with other omega fatty acids for enhanced benefits.

Reported Mechanism (Provisional)

Mechanism of Action

GLA converts to dihomo-gamma-linolenic acid (DGLA) via delta-6-desaturase enzyme, then to anti-inflammatory prostaglandin E1 (PGE1) through cyclooxygenase. This pathway counteracts pro-inflammatory arachidonic acid metabolites, reducing inflammatory cytokines IL-1β and TNF-α. GLA also enhances ceramide synthesis in skin cells, strengthening the epidermal barrier.

Clinical Narrative (Provisional)

A 12-week randomized controlled trial with 120 participants showed GLA supplementation (500mg daily) increased skin hydration by 25% and reduced trans-epidermal water loss. Meta-analysis of 8 studies involving 349 eczema patients demonstrated significant reduction in inflammation scores with 240-500mg daily GLA. Smaller studies suggest benefits for PMS symptoms, but evidence remains limited with mixed results across trials.

Also Known As

Octadecatrienoic acid18:3 n-6cis-6,9,12-Octadecatrienoic acidGamma linolenic acidGLA omega-6Evening primrose fatty acidBorage seed acid

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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