# Genkwanin

**Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/genkwanin
**Data Source:** Hermetica Superfoods Ingredient Encyclopedia
**Updated:** 2026-03-23
**Evidence Score:** 2 / 10
**Category:** Compound
**Also Known As:** 5,7-dihydroxy-4'-methoxyflavone, Apigenin 4'-methyl ether, Yuan Hua flavone, Daphne genkwa flavone, 4'-O-methylapigenin, Genkwa flavonoid

## Overview

Genkwanin is a naturally occurring flavone aglycone found in plants such as Genkwa Flos and Achillea millefolium that exerts anticancer and [anti-inflammatory](/ingredients/condition/inflammation) effects primarily by modulating NF-κB signaling and cytokine production. It suppresses pro-inflammatory mediators including TNF-α and IL-6 while upregulating the anti-inflammatory cytokine IL-10, and demonstrates tumor inhibition comparable to the chemotherapy drug paclitaxel in preclinical models.

## Health Benefits

• May inhibit tumors, achieving a 62.09% inhibition rate in mice, comparable to paclitaxel [1]. • Reduces inflammation markers such as TNF-α and IL-6 in arthritis models [3]. • Enhances IL-10 levels, an anti-inflammatory cytokine, in animal studies [3]. • Potentially inhibits pro[inflammatory pathway](/ingredients/condition/inflammation)s including JAK/STAT and NF-κB [3]. • Shows good safety profile in animal models with high tolerance levels [1].

## Mechanism of Action

Genkwanin inhibits the NF-κB proinflammatory signaling pathway, thereby suppressing downstream transcription of [pro-inflammatory cytokine](/ingredients/condition/inflammation)s TNF-α and IL-6 in immune and synovial cells. It concurrently enhances production of IL-10, an anti-inflammatory cytokine that counterbalances inflammatory cascades. In tumor models, genkwanin is believed to induce apoptosis and inhibit cell proliferation through interference with cell cycle regulatory proteins, showing activity comparable to paclitaxel's microtubule-stabilizing mechanism at equivalent study doses.

## Clinical Summary

Current evidence for genkwanin is limited to in vitro cell studies and in vivo animal models, with no published human clinical trials as of early 2025. In murine tumor models, genkwanin achieved a 62.09% tumor inhibition rate, a result statistically comparable to paclitaxel in the same experimental cohorts. Arthritis animal models demonstrated significant reductions in TNF-α and IL-6 concentrations alongside elevated IL-10 levels following genkwanin administration. While these preclinical findings are promising, the absence of human pharmacokinetic data, optimal dosing, and randomized controlled trials means the evidence base remains preliminary and extrapolation to human clinical use is not yet supported.

## Nutritional Profile

Genkwanin (4',5-dihydroxy-7-methoxyflavone; C₁₆H₁₂O₅; MW 284.26 g/mol) is a naturally occurring O-methylated flavone, not a nutritional macronutrient source. It provides no significant calories, protein, fat, fiber, or carbohydrates at bioactive doses. Key biochemical and bioactive details: • Found naturally in plants such as Daphne genkwa (flower buds), Rosmarinus officinalis (rosemary), and certain Alnus (alder) species, typically at trace concentrations (often <0.1% dry weight of plant material). • Structurally, it is the 7-O-methyl ether of apigenin, featuring two free hydroxyl groups at C-4' and C-5 and a methoxy group at C-7, which influences its lipophilicity (estimated LogP ~2.7–3.0) and membrane permeability. • As a flavonoid aglycone, its oral bioavailability is expected to be low to moderate, limited by poor aqueous solubility, extensive Phase II [metabolism](/ingredients/condition/weight-management) (glucuronidation and sulfation in the intestinal wall and liver), and potential efflux by P-glycoprotein transporters. • No vitamins or minerals are contributed at pharmacologically relevant doses (typically studied in the low mg/kg range in animal models). • Primary bioactive properties stem from interactions with molecular targets: reported IC₅₀ values in various cancer cell lines range roughly from 10–100 µM in vitro; [anti-inflammatory](/ingredients/condition/inflammation) activity involves suppression of TNF-α and IL-6 (observed at concentrations around 10–50 µM in cell-based assays) and upregulation of IL-10. • Contains no essential amino acids, fatty acids, or dietary fiber. • Bioavailability may be enhanced through lipid-based delivery systems, nanoformulations, or co-administration with absorption enhancers (e.g., piperine), though clinical pharmacokinetic data in humans remain limited. • Typical analytical quantification in plant extracts is performed via HPLC-UV/MS, with concentrations reported in the range of 0.01–5 mg/g of dried extract depending on plant source and extraction method.

## Dosage & Preparation

In animal studies, genkwanin nanosuspensions were given at 20-60 mg/kg intravenously every other day for 10 days. No human dosages are established. Consult a healthcare provider before starting any new supplement.

## Safety & Drug Interactions

No established safety profile or standardized dosage for genkwanin in humans exists, as clinical trials have not yet been conducted. Because genkwanin inhibits NF-κB and modulates [cytokine](/ingredients/condition/inflammation) activity, theoretical interactions with immunosuppressant drugs such as corticosteroids, methotrexate, or biologics targeting TNF-α are plausible and warrant caution. Pregnant or breastfeeding individuals should avoid genkwanin supplementation entirely, given the lack of reproductive safety data and the known cytotoxic activity observed in cell models. Individuals on anticoagulant or chemotherapy regimens should consult a physician before use, as flavone compounds can influence CYP450 enzyme [metabolism](/ingredients/condition/weight-management) and alter drug clearance.

## Scientific Research

There are no human clinical trials or meta-analyses available for genkwanin. Evidence is limited to preclinical in vitro and animal studies, such as those demonstrating tumor inhibition in mice (PMID: 28961040) and [anti-inflammatory](/ingredients/condition/inflammation) effects in rats (PMID: 31401534).

## Historical & Cultural Context

Genkwanin is derived from Daphne genkwa, a plant used in traditional Chinese medicine. While specific historical uses of genkwanin are not detailed, the parent herb is linked to anti-arthritic effects traditionally.

## Synergistic Combinations

Quercetin, Resveratrol, Curcumin, Green Tea Extract, Omega-3 Fatty Acids

## Frequently Asked Questions

### What is genkwanin and what plants does it come from?

Genkwanin is a flavone aglycone, meaning it is a flavone compound without attached sugar molecules. It is naturally found in Daphne genkwa (Genkwa Flos), Achillea millefolium (yarrow), and several other medicinal herbs. It can also be produced by hydrolysis of its glycoside form, genkwanin-5-O-glucoside.

### How does genkwanin compare to paclitaxel for cancer?

In mouse tumor models, genkwanin achieved a 62.09% tumor inhibition rate, a figure described as comparable to paclitaxel tested under the same experimental conditions. However, paclitaxel is an FDA-approved chemotherapy drug with extensive human clinical data, while genkwanin has only preclinical evidence. No head-to-head human trials exist, and genkwanin cannot be considered a clinical substitute for paclitaxel at this time.

### Does genkwanin reduce inflammation, and which markers does it affect?

Yes, in arthritis animal models genkwanin significantly reduced levels of TNF-α (tumor necrosis factor-alpha) and IL-6, two key pro-inflammatory cytokines involved in chronic inflammatory conditions. Simultaneously, it elevated IL-10, an anti-inflammatory cytokine that helps resolve inflammation. These effects are mediated at least partly through inhibition of the NF-κB signaling pathway.

### Is there a recommended dosage for genkwanin supplements?

No standardized human dosage for genkwanin has been established, as no clinical trials have determined safe or effective doses in people. All dosing data currently comes from animal studies, where doses are typically administered in milligrams per kilogram of body weight and cannot be directly translated to human supplementation. Anyone considering genkwanin supplementation should consult a qualified healthcare provider before use.

### Can genkwanin interact with prescription medications?

Genkwanin theoretically interacts with drugs metabolized by CYP450 liver enzymes, a common pathway for many pharmaceuticals, potentially altering their blood concentrations. Its cytokine-modulating activity may also interfere with immunosuppressants, TNF-α inhibitors, or corticosteroids used in autoimmune conditions. Individuals taking anticoagulants, chemotherapy agents, or immunomodulatory drugs should seek medical advice before using genkwanin-containing products.

### What does the research show about genkwanin's effectiveness against cancer compared to conventional treatments?

Animal studies demonstrate that genkwanin achieves a 62.09% tumor inhibition rate in mice, which is comparable to paclitaxel, a standard chemotherapy drug. However, these results are from preclinical research, and human clinical trials are needed to establish efficacy and safety in cancer patients. Genkwanin's mechanism appears to involve multiple pathways, but translation to clinical use remains in early stages.

### Is genkwanin safe for long-term use based on current safety data?

Animal models have shown a good safety profile with high tolerance to genkwanin, suggesting low toxicity potential. However, long-term human safety studies have not been extensively conducted, and data on chronic supplementation in people remains limited. Anyone considering long-term use should consult a healthcare provider to assess individual risk factors and monitor for unexpected effects.

### Which inflammatory conditions might benefit most from genkwanin supplementation?

Genkwanin shows promise for conditions involving elevated TNF-α and IL-6, such as arthritis, based on animal model studies demonstrating significant reductions in these inflammatory markers. The compound also enhances IL-10 production, an anti-inflammatory cytokine, and may inhibit JAK/STAT and NF-κB pathways involved in chronic inflammation. However, evidence is primarily from animal research, and clinical efficacy in specific human inflammatory diseases has not been established.

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