# Gardenin B **Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/gardenin-b **Data Source:** Hermetica Superfoods Ingredient Encyclopedia **Updated:** 2026-03-28 **Evidence Score:** 2 / 10 **Category:** Compound **Also Known As:** 5,6,7,8-Tetramethoxyflavone, Tetramethoxyflavone, Gardenin-B, 5,6,7,8-Tetramethoxy-2-(4-hydroxyphenyl)-4H-chromen-4-one, TMF, Citrus tetramethoxyflavone ## Overview Gardenin B is a polymethoxylated flavonoid compound derived from Gardenia species that exhibits antioxidant and anti-inflammatory properties. This bioactive flavonoid works primarily through [free radical scaveng](/ingredients/condition/antioxidant)ing and modulation of [inflammatory pathway](/ingredients/condition/inflammation)s. ## Health Benefits • Potential [antioxidant](/ingredients/condition/antioxidant) properties[1]. • May support [cardiovascular health](/ingredients/condition/heart-health) due to flavonoid activity[1]. • Could exhibit [anti-inflammatory](/ingredients/condition/inflammation) effects[1]. • Possible [neuroprotective](/ingredients/condition/cognitive) benefits[1]. • Might aid in metabolic health management[1]. ## Mechanism of Action Gardenin B exerts its biological effects primarily through [free radical scaveng](/ingredients/condition/antioxidant)ing via electron donation and hydrogen atom transfer mechanisms. The compound modulates inflammatory pathways by inhibiting [pro-inflammatory cytokine](/ingredients/condition/inflammation)s and may influence nitric oxide synthase activity. Its polymethoxylated structure enhances cellular membrane stability and provides protection against oxidative stress. ## Clinical Summary Current research on Gardenin B is primarily limited to in vitro and animal studies, with minimal human clinical data available. Laboratory studies have demonstrated antioxidant activity with IC50 values in the micromolar range for [free radical scaveng](/ingredients/condition/antioxidant)ing. Animal studies suggest potential [cardiovascular](/ingredients/condition/heart-health) benefits, though sample sizes have been small and study durations limited. Human clinical trials are needed to establish therapeutic efficacy and optimal dosing protocols. ## Nutritional Profile Gardenin B is a polymethoxylated flavone (PMF) compound, not a dietary macronutrient source. It contains no meaningful protein, carbohydrate, fat, or fiber content as it is a pure bioactive phytochemical. Molecular formula: C20H20O8, molecular weight approximately 392.36 g/mol. It belongs to the flavone subclass of flavonoids, characterized by a 4',5,6,7-tetramethoxyflavone-3'-hydroxy backbone with multiple methoxy (-OCH3) substitutions that distinguish it from non-methylated flavones. Bioactive compound concentration: found naturally in the peel of citrus fruits (particularly species such as Citrus reticulata and related varieties) at trace concentrations estimated in the range of 0.1–10 mg per 100g of dried peel material, though isolation yields vary significantly by species and extraction method. No established dietary reference intake or RDA exists. Bioavailability notes: Polymethoxylated flavones like Gardenin B generally exhibit higher lipophilicity compared to hydroxylated flavonoids, which may improve passive intestinal absorption but limits aqueous solubility. [Metabolism](/ingredients/condition/weight-management) likely involves hepatic cytochrome P450 enzymes (CYP1A2, CYP3A4) with demethylation producing hydroxylated metabolites. Micronutrient content is not applicable as this is an isolated phytochemical compound, not a whole food matrix. [Antioxidant](/ingredients/condition/antioxidant) capacity attributed to the residual free hydroxyl group at the 3' position. ## Dosage & Preparation No clinically studied dosage ranges or standardized extract concentrations are available from the current research. Consult a healthcare provider before starting any new supplement. ## Safety & Drug Interactions Safety data for Gardenin B is limited due to insufficient human studies. As a flavonoid compound, it may potentially interact with anticoagulant medications by affecting platelet aggregation. Pregnant and breastfeeding women should avoid supplementation due to lack of safety data. Individuals with bleeding disorders or those scheduled for surgery should exercise caution due to potential antiplatelet effects. ## Scientific Research The available research does not cite specific human clinical trials or meta-analyses with PMIDs for gardenin B. Further peer-reviewed literature is needed to establish clinical efficacy. ## Historical & Cultural Context The research dossier does not provide information about the traditional or historical use of gardenin B in any medicinal systems. Further research is required for historical context. ## Synergistic Combinations Vitamin C, Quercetin, Resveratrol, L-Theanine, CoQ10 ## Frequently Asked Questions ### What foods contain Gardenin B naturally? Gardenin B is primarily found in Gardenia species plants, particularly Gardenia jasminoides. It may also be present in other citrus-related plants, though Gardenia remains the most concentrated natural source. ### How much Gardenin B should I take daily? No established daily dosage exists for Gardenin B due to limited human clinical trials. Research studies have used varying concentrations, but standardized supplementation guidelines have not been established by health authorities. ### Can Gardenin B help with inflammation? Laboratory studies suggest Gardenin B may reduce inflammatory markers by inhibiting pro-inflammatory cytokines. However, human clinical evidence is lacking, and anti-inflammatory effects have only been demonstrated in cell culture and animal models. ### Is Gardenin B the same as other garden flavonoids? Gardenin B is a specific polymethoxylated flavonoid distinct from other plant compounds. While it shares some structural similarities with other flavonoids, its unique methoxyl group arrangement gives it different biological properties and activities. ### Does Gardenin B interact with blood pressure medications? Potential interactions with cardiovascular medications are theoretically possible due to Gardenin B's flavonoid activity on vascular function. However, specific drug interactions have not been clinically studied, so consultation with healthcare providers is recommended. ### What does research show about Gardenin B's antioxidant effectiveness compared to other flavonoids? Gardenin B exhibits potent antioxidant activity as a flavonoid compound, helping neutralize free radicals that contribute to cellular damage and aging. While direct comparative studies between Gardenin B and other individual flavonoids are limited, its structural properties suggest antioxidant capacity similar to related garden-derived flavonoids, though more human clinical trials are needed to establish its relative efficacy. ### Who would benefit most from taking Gardenin B supplements? Gardenin B may be particularly beneficial for individuals seeking cardiovascular support, those with elevated oxidative stress, or people interested in neuroprotective supplementation. Those with metabolic health concerns or chronic inflammatory conditions might also consider Gardenin B, though anyone with existing health conditions should consult a healthcare provider before starting supplementation. ### How does the bioavailability of Gardenin B affect how well the body can use it? As a flavonoid, Gardenin B's bioavailability depends on factors such as supplement form, presence of food or other compounds that enhance absorption, and individual digestive health. Taking Gardenin B with dietary fat may improve absorption, and consuming it alongside vitamin C or other antioxidants may enhance its utilization within the body, though specific bioavailability data for Gardenin B is limited. --- *Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com* *License: CC BY-NC-SA 4.0 — Attribution required. Commercial use: admin@hermeticasuperfoods.com*