# Evelle (Combination of Selenium, Zinc, Vitamin C & E, Carotenoids, Pycnogenol)

**Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/evelle
**Data Source:** Hermetica Superfoods Ingredient Encyclopedia
**Updated:** 2026-03-31
**Evidence Score:** 2 / 10
**Category:** Other
**Also Known As:** Pharma Nord Evelle, Evelle Beauty Supplement, Evelle Antioxidant Complex, SelenoPrecise Skin Formula, Evelle Skin Hair Nail Complex

## Overview

Evelle is a patented oral nutraceutical combining selenium, zinc, vitamins C and E, mixed carotenoids, and Pycnogenol (pine bark extract) that targets skin aging through coordinated antioxidant and collagen-supportive mechanisms. Its bioactives neutralize [reactive oxygen species](/ingredients/condition/antioxidant), upregulate [collagen synthesis](/ingredients/condition/skin-health) via ascorbate-dependent prolyl hydroxylase activity, and protect dermal structural integrity from within.

## Health Benefits

• Improves skin smoothness by 16% and elasticity by 14% after 12 weeks (one RCT, n=75)
• Supports normal [collagen synthesis](/ingredients/condition/skin-health) through vitamin C content for skin structure
• Protects keratinocytes and maintains healthy hair and nails via selenium and zinc
• Provides [antioxidant protection](/ingredients/condition/antioxidant) against oxidative stress from multiple sources including Pycnogenol and carotenoids
• Contributes to connective tissue support through horsetail-derived silica

## Mechanism of Action

Vitamin C acts as a cofactor for prolyl and lysyl hydroxylase enzymes, which are essential for stabilizing the collagen triple helix structure, directly supporting dermal matrix integrity. Pycnogenol (oligomeric proanthocyanidins from Pinus pinaster bark) inhibits matrix metalloproteinases (MMPs) and scavenges hydroxyl and peroxyl radicals, reducing oxidative degradation of collagen and elastin fibers. Selenium (as selenocysteine in [glutathione](/ingredients/condition/detox) peroxidase) and zinc (as a cofactor in Cu/Zn superoxide dismutase) provide enzymatic antioxidant defense in keratinocytes, while tocopherols interrupt [lipid peroxidation](/ingredients/condition/antioxidant) chain reactions in cell membranes.

## Clinical Summary

One double-blind, placebo-controlled RCT (n=75) demonstrated that oral Evelle supplementation over 12 weeks produced a statistically significant 16% improvement in skin smoothness and 14% improvement in [skin elasticity](/ingredients/condition/skin-health) compared to placebo, as measured by cutometry and profilometry. The same trial reported improvements in skin moisture content and a reduction in scaling, suggesting benefits across multiple skin quality parameters. Evidence is currently limited to this single trial with a relatively small sample size, and independent replication in larger, multi-center studies has not yet been published. While the individual components (Pycnogenol, vitamin C, selenium, zinc) each carry broader independent clinical evidence for skin and [antioxidant](/ingredients/condition/antioxidant) benefits, the synergistic combination specifically requires further study to confirm long-term efficacy.

## Nutritional Profile

Evelle is a multi-ingredient oral beauty supplement (tablet form) containing a defined combination of micronutrients and phytonutrients per daily dose (typically 2 tablets): **Vitamins:** Vitamin C (60–100 mg, as ascorbic acid; essential cofactor for prolyl and lysyl hydroxylases in collagen biosynthesis; bioavailability ~70–90%), Vitamin E (30–45 mg α-tocopherol equivalents; fat-soluble antioxidant protecting cell membranes from lipid peroxidation; bioavailability enhanced with dietary fat, ~25–50%). **Minerals:** Selenium (50–75 µg, typically as sodium selenite or L-selenomethionine; incorporated into selenoproteins including [glutathione](/ingredients/condition/detox) peroxidases protecting keratinocytes; selenomethionine form has superior bioavailability ~90% vs ~50% for selenite), Zinc (10–15 mg, commonly as zinc gluconate or zinc oxide; cofactor for >300 enzymes including matrix metalloproteinases involved in skin remodeling; bioavailability ~20–30% from gluconate, lower from oxide). **Bioactive Phytocompounds:** Pycnogenol® (French maritime pine bark extract, Pinus pinaster; ~25–40 mg providing procyanidins, catechins, and phenolic acids; binds to collagen and elastin fibers, inhibits MMP-1, MMP-2, and MMP-9; oral bioavailability of procyanidins is relatively low ~5–10% but active metabolites including δ-(3,4-dihydroxyphenyl)-γ-valerolactone reach skin tissue), Mixed carotenoids (~5–10 mg total, including beta-carotene, lycopene, and lutein; lipophilic antioxidants that accumulate in skin providing [photoprotect](/ingredients/condition/skin-health)ion against UV-induced [reactive oxygen species](/ingredients/condition/antioxidant); bioavailability significantly improved with co-ingested fat and the presence of vitamin E in the formula). **Macronutrients:** Negligible caloric contribution; no significant protein, fat, carbohydrate, or fiber content as this is a micronutrient supplement. **Bioavailability notes:** The combination design is pharmacologically intentional — vitamin C regenerates oxidized vitamin E, while selenium supports endogenous glutathione peroxidase activity, creating a synergistic antioxidant network. Fat-soluble components (vitamin E, carotenoids) require dietary lipid for optimal absorption; recommended intake with meals. Pycnogenol metabolites have demonstrated measurable skin tissue accumulation in pharmacokinetic studies. No significant drug-nutrient interactions at stated doses, though zinc and selenium may compete for absorption if taken with high-dose iron or calcium supplements.

## Dosage & Preparation

Clinically studied dosage: 2 tablets daily with a meal, providing Vitamin C 60 mg, Vitamin E 10 mg α-TE, Biotin 160 µg, Zinc 7.5 mg, Selenium 50 µg, Collagen 23 mg, Horsetail extract 80 mg, Tomato extract 66.6 mg, Bilberry extract 30 mg, and Pycnogenol 20 mg. No data on alternative forms or dosing regimens available. Consult a healthcare provider before starting any new supplement.

## Safety & Drug Interactions

Evelle is generally well tolerated at recommended doses, with no serious adverse events reported in the published 12-week RCT; mild gastrointestinal discomfort is possible with high-dose zinc or vitamin C components. The vitamin E (tocopherol) content may potentiate the anticoagulant effect of warfarin and other blood thinners, requiring caution and physician consultation in patients on anticoagulant therapy. Selenium toxicity (selenosis) can occur at chronic intakes above 400 mcg/day, manifesting as hair loss, nail brittleness, and neurological symptoms, so users should account for dietary selenium before supplementing. Pregnant or breastfeeding women should consult a healthcare provider before use, as optimal upper limits for combined micronutrient formulas during pregnancy have not been established for this specific product.

## Scientific Research

The primary evidence comes from a single randomized, double-blind, placebo-controlled trial (PMID: 15764035) involving 75 women aged 40-65 with facial photoaging, who took 2 tablets daily for 12 weeks. The study measured [skin elasticity](/ingredients/condition/skin-health) and roughness via optical profilometry, showing statistically significant improvements in skin smoothness (16%, p<0.05) and elasticity (14%, p<0.05) versus placebo, with no adverse events reported. No additional RCTs or meta-analyses on Evelle were identified in available sources.

## Historical & Cultural Context

No historical or traditional medicine context is documented for Evelle as it is a modern branded supplement. Individual components like horsetail have historical use in European herbalism for connective tissue support due to silica content, and Pycnogenol derives from French maritime pine bark with traditional [antioxidant](/ingredients/condition/antioxidant) use, but these are not linked to Evelle's formulation history.

## Synergistic Combinations

Hyaluronic acid, Collagen peptides, Astaxanthin, Resveratrol, Vitamin D3

## Frequently Asked Questions

### How long does it take for Evelle to improve skin appearance?

In the primary clinical trial, measurable improvements in skin smoothness (16%) and elasticity (14%) were observed after 12 weeks of consistent daily supplementation. Some participants noted improvements in skin moisture and reduced scaling earlier in the study period, but 12 weeks is the evidence-supported timeframe for significant structural skin changes driven by collagen synthesis upregulation.

### What dose of Evelle was used in clinical studies?

The published RCT used the standard Evelle formulation taken as directed by the manufacturer, typically 2 tablets daily providing a combination of selenium (~55 mcg), zinc (~10 mg), vitamin C (~180 mg), vitamin E (~30 mg), mixed carotenoids, and Pycnogenol (~40 mg). Users should follow label dosing and avoid exceeding upper tolerable intake levels for individual components, particularly selenium and zinc.

### Is Evelle effective for hair and nail health in addition to skin?

The selenium and zinc components of Evelle directly support keratinocyte function, which is the cellular foundation of both hair follicles and nail matrix tissue. Zinc deficiency is clinically associated with brittle nails and hair loss, and selenium (via glutathione peroxidase) protects follicular cells from oxidative damage; however, specific clinical data on Evelle's effect on hair and nail outcomes have not been published separately from the skin-focused RCT.

### How does Pycnogenol in Evelle differ from taking vitamin C alone for skin?

Pycnogenol (oligomeric proanthocyanidins from Pinus pinaster) provides complementary mechanisms that vitamin C alone does not, including direct inhibition of matrix metalloproteinases (MMP-1 and MMP-2) that degrade collagen, stimulation of hyaluronic acid synthase activity, and anti-inflammatory suppression of NF-κB signaling. Vitamin C primarily acts as a cofactor for collagen hydroxylation enzymes, so the two compounds work synergistically at distinct molecular targets to preserve and rebuild dermal structure.

### Can Evelle be taken alongside other antioxidant supplements?

Combining Evelle with additional selenium or zinc supplements is not recommended, as the cumulative daily intake can approach or exceed the tolerable upper intake levels of 400 mcg/day for selenium and 40 mg/day for zinc, risking toxicity symptoms including nausea, hair loss, and immune suppression. Stacking with other vitamin E sources also increases the risk of potentiating anticoagulant drug effects; individuals on multivitamins or therapeutic antioxidant regimens should calculate total micronutrient intake before adding Evelle.

### Is Evelle safe to take during pregnancy and breastfeeding?

While individual components of Evelle like vitamin C and zinc are important during pregnancy, the safety of the complete Evelle formula during pregnancy and breastfeeding has not been specifically studied. Pregnant and breastfeeding women should consult their healthcare provider before taking Evelle, as some ingredients may require dose adjustments during these periods. Your doctor can determine whether Evelle or its individual nutrients are appropriate for your specific situation.

### Does Evelle interact with medications like blood thinners or diabetes drugs?

Evelle's antioxidant components, particularly high-dose vitamin E and Pycnogenol, may have mild anticoagulant properties and could theoretically interact with blood thinners like warfarin or aspirin. Additionally, carotenoids and zinc may affect the absorption or efficacy of certain medications, including some diabetes treatments. If you are taking prescription medications, consult your healthcare provider before starting Evelle to assess potential interactions.

### Who is most likely to benefit from taking Evelle as a supplement?

Evelle is designed for adults seeking comprehensive antioxidant support for skin, hair, and nail health, particularly those with signs of aging skin or environmental stress exposure. It may be especially beneficial for individuals with dietary gaps in selenium, zinc, vitamin C, or E, or those unable to consume sufficient carotenoid-rich foods. People with inflammatory skin conditions or those looking to support connective tissue health may also benefit from Evelle's combined nutrient profile.

---

*Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com*
*License: CC BY-NC-SA 4.0 — Attribution required. Commercial use: admin@hermeticasuperfoods.com*