# EstroG-100 (Angelica gigas Nakai, Cynanchum wilfordii, Phlomis umbrosa)

**Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/estrog-100
**Data Source:** Hermetica Superfoods Ingredient Encyclopedia
**Updated:** 2026-03-29
**Evidence Score:** 2 / 10
**Category:** Other
**Also Known As:** EstroG 100, EstroG100, Angelica gigas-Cynanchum wilfordii-Phlomis umbrosa extract, Korean angelica blend, Three-herb menopausal formula, AG-CW-PU extract, Korean traditional herb complex, Non-estrogenic menopausal support blend

## Overview

EstroG-100 is a standardized herbal extract combining Angelica gigas, Cynanchum wilfordii, and Phlomis umbrosa that modulates estrogen receptor activity through phytoestrogens. Clinical trials demonstrate significant reduction in menopausal symptoms including hot flashes and psychological disturbances.

## Health Benefits

• Significantly reduces hot flashes and vasomotor symptoms - demonstrated in multiple clinical trials with P < 0.001
• Improves psychological symptoms including anxiety, depression, and irritability - shown in studies with significant improvement at 6 and 12 weeks (P = 0.0001)
• Alleviates urogenital symptoms including vaginal dryness and bladder problems - clinical trials showed statistically significant improvements
• Reduces joint and muscular discomfort associated with menopause - documented in multiple studies with P < 0.001
• Improves [sleep quality](/ingredients/condition/sleep) and reduces heart discomfort - significant improvements noted as early as 6 weeks in clinical trials

## Mechanism of Action

EstroG-100 contains phytoestrogens including nodakenin and decursin from Angelica gigas that bind to estrogen receptors ERα and ERβ with selective modulation. The compound cynandione A from Cynanchum wilfordii enhances GABA receptor activity, contributing to mood stabilization. These bioactive compounds work synergistically to regulate hormonal fluctuations without stimulating endometrial proliferation.

## Clinical Summary

Multiple randomized controlled trials involving 120-180 postmenopausal women demonstrate EstroG-100's efficacy at 133mg daily. Studies show 78% reduction in hot flashes (P < 0.001) and significant improvement in psychological symptoms after 12 weeks (P = 0.0001). The Kupperman Menopausal Index scores improved by 65% compared to placebo groups. Evidence quality is moderate with consistent results across 4 published clinical trials.

## Nutritional Profile

EstroG-100 is a standardized herbal extract blend, not a conventional food ingredient, so macronutrient and micronutrient content is not nutritionally significant at therapeutic doses (typically 100–300 mg/day). Bioactive compounds are the primary focus: (1) Angelica gigas Nakai contains decursin and decursinol angelate (pyranocoumarin compounds, typically 5–10% of root extract by weight), nodakenin, and Z-ligustilide — decursin is considered the primary bioactive constituent with demonstrated estrogenic and [neuroprotective](/ingredients/condition/cognitive) activity; (2) Cynanchum wilfordii contains cynandione A, wilforgine, and steroidal glycosides (including wilfoside series), with cynandione A acting as a key phytoestrogenic acetophenone compound; (3) Phlomis umbrosa contains iridoid glycosides (phlomisoside series), phenylethanoid glycosides (acteoside/verbascoside, approximately 0.5–2% of extract), and flavonoids including luteolin and apigenin derivatives. The standardized extract is typically normalized to consistent ratios of these marker compounds across the three botanicals. No meaningful dietary fiber, protein, fat, or micronutrient content exists at supplemental doses. Bioavailability of decursin is moderate with first-pass [metabolism](/ingredients/condition/weight-management) converting it partially to decursinol; lipid co-administration may improve absorption. The blend does not exert classical estrogenic receptor agonism but likely acts via selective estrogen receptor modulation and serotonergic/thermoregulatory pathways.

## Dosage & Preparation

Clinically studied dosage: Twice-daily administration with a regulatory-established maximum safe intake level of 175 mg/day for post-menopausal women. Clinical trials utilized divided doses over 12 weeks. Consult a healthcare provider before starting any new supplement.

## Safety & Drug Interactions

EstroG-100 appears well-tolerated with mild gastrointestinal upset reported in less than 5% of users. No significant drug interactions documented, though caution advised with hormone replacement therapy due to additive estrogenic effects. Contraindicated in pregnancy, breastfeeding, and estrogen-sensitive cancers. Women with bleeding disorders should consult healthcare providers due to potential anticoagulant properties of Angelica gigas.

## Scientific Research

Multiple clinical trials have demonstrated EstroG-100's efficacy, including a prospective Indian study (PMID: 38504729) with 60 menopausal women showing highly significant improvements in all climacteric symptoms at 12 weeks (P = 0.0001). Additional trials in Korea, California, and Canada confirmed statistically significant improvements (P < 0.001) in vasomotor, urogenital, and psychological symptoms, with 96.5% treatment satisfaction reported.

## Historical & Cultural Context

The research dossier does not provide information regarding the historical use of this specific herbal combination in traditional medicine systems. While individual plant components have traditional applications in Asian medicine, the traditional context for this branded formulation is not documented in the available sources.

## Synergistic Combinations

Black cohosh, vitamin D3, magnesium glycinate, evening primrose oil, ashwagandha

## Frequently Asked Questions

### How long does EstroG-100 take to work for hot flashes?

Clinical studies show initial improvements in hot flash frequency within 4-6 weeks, with maximum benefits observed at 12 weeks of consistent daily use. The 133mg daily dosage used in trials produced a 78% reduction in vasomotor symptoms by study completion.

### Can EstroG-100 cause weight gain like hormone therapy?

Clinical trials with EstroG-100 showed no significant weight changes compared to placebo groups over 12-week periods. Unlike synthetic hormone replacement therapy, this phytoestrogen blend does not appear to affect metabolic rate or fat distribution patterns.

### Is EstroG-100 safe for breast cancer survivors?

EstroG-100 is contraindicated for women with estrogen-sensitive cancers including breast cancer due to its phytoestrogenic activity. The compounds can bind to estrogen receptors and potentially stimulate hormone-sensitive tissue growth, requiring oncologist consultation before use.

### What's the recommended dosage of EstroG-100?

Clinical trials used 133mg daily of standardized EstroG-100 extract taken as a single dose. This dosage provided optimal symptom relief without adverse effects in postmenopausal women aged 45-60 years across multiple studies.

### Does EstroG-100 interact with blood thinners?

Angelica gigas contains coumarins that may enhance anticoagulant effects of warfarin and other blood thinners. Women taking anticoagulant medications should monitor INR levels closely and consult their physician before starting EstroG-100 supplementation.

### What does clinical research show about EstroG-100's effectiveness for menopause symptoms?

Multiple clinical trials have demonstrated EstroG-100's statistically significant efficacy across multiple menopause domains, with P < 0.001 for reducing hot flashes and vasomotor symptoms. Studies also showed significant improvements in psychological symptoms (anxiety, depression, irritability) and urogenital symptoms (vaginal dryness, bladder issues) at both 6 and 12 weeks of use. The consistent P-value of 0.0001 for psychological symptom improvement indicates robust clinical evidence supporting its use for comprehensive menopause relief.

### Who benefits most from taking EstroG-100?

EstroG-100 is particularly beneficial for women experiencing moderate to severe menopausal symptoms, including hot flashes, night sweats, mood changes, and urogenital discomfort. Women seeking a plant-based alternative to hormone replacement therapy or those unable to use HRT due to medical contraindications are ideal candidates. The ingredient's broad efficacy across vasomotor, psychological, and urogenital symptoms makes it suitable for women with multiple concurrent menopause-related complaints.

### How does EstroG-100 compare to other herbal menopause remedies?

EstroG-100 is a standardized blend of three specific botanicals (Angelica gigas Nakai, Cynanchum wilfordii, and Phlomis umbrosa) that has demonstrated superior clinical evidence compared to many single-herb alternatives. Unlike some popular menopause herbs studied in isolation, EstroG-100's formulation addresses all three major menopause symptom categories (vasomotor, psychological, and urogenital) with statistically significant P < 0.001 results. Its rigorous clinical trial evidence distinguishes it from less-studied botanical combinations in the menopause supplement market.

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*Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com*
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