# Dodonaea Leaf **Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/dodonaea-leaf **Data Source:** Hermetica Superfoods Ingredient Encyclopedia **Updated:** 2026-03-15 **Evidence Score:** 4 / 10 **Category:** Leaf/Green **Also Known As:** Dodonaea viscosa, Hop bush, Sticky hopbush, Broadleaf hopbush, Hopseed bush ## Overview Dodonaea viscosa leaf contains bioactive flavonoids including kaempferol, quercetin, and apigenin, along with tannins and saponins that demonstrate [antimicrobial](/ingredients/condition/immune-support), [antioxidant](/ingredients/condition/antioxidant), and [anti-inflammatory](/ingredients/condition/inflammation) properties. Its mechanisms include inhibiting lipoxygenase pathways, reducing inflammatory mediators like TNF-α and PGE2, and inducing G2-M phase cell cycle arrest. ## Health Benefits - **Reduces inflammation and**: pain by modulating [inflammatory pathway](/ingredients/condition/inflammation)s. - **Supports wound healing**: and skin regeneration through its antimicrobial and tissue-repairing properties. - **Eases respiratory congestion**: and soothes airways. - **Modulates [immune function](/ingredients/condition/immune-support),**: enhancing the body's natural defenses. - **Aids [liver detox](/ingredients/condition/detox)ification**: processes, supporting systemic cleansing. - **Defends against oxidative**: stress with its rich [antioxidant](/ingredients/condition/antioxidant) compounds. ## Mechanism of Action Dodonaea viscosa leaf flavonoids including kaempferol and quercetin inhibit lipoxygenase enzymes while reducing [inflammatory](/ingredients/condition/inflammation) mediators NO, PGE2, and TNF-α in LPS-stimulated macrophages. The compound viscosine specifically targets lipoxygenase via molecular docking mechanisms, while hautriwaic acid provides [hepatoprotect](/ingredients/condition/detox)ion against ROS-induced oxidative damage. Tannins and saponins contribute bactericidal effects against Enterobacteriaceae through cell membrane disruption. ## Clinical Summary Current evidence for Dodonaea viscosa leaf is limited to preclinical in vitro and animal studies, with no published human clinical trials available. Animal studies using CCl4-induced liver damage models showed restoration of ALT, AST, ALP enzyme levels and [antioxidant](/ingredients/condition/antioxidant) markers SOD, GPx, and CAT. In vitro studies demonstrate antioxidant IC50 values of 27.44 μM (DPPH assay) for isolated compounds, while ethanolic extracts showed bactericidal activity against gram-negative bacteria. Human clinical trials are essential to establish therapeutic efficacy, optimal dosing, and safety profiles for medicinal applications. ## Nutritional Profile - Flavonoids: Quercetin and kaempferol, providing potent [anti-inflammatory](/ingredients/condition/inflammation) and [antioxidant](/ingredients/condition/antioxidant) actions. - Clerodane Diterpenoids: Contribute to its anti-inflammatory and antimicrobial defense. - Tannins: Offer astringent properties, supporting tissue repair and antimicrobial effects. - Saponins: May contribute to [immune modulation](/ingredients/condition/immune-support) and anti-inflammatory benefits. - Volatile Oils & Resins: Provide antimicrobial and respiratory-easing properties. - Trace Minerals: Including zinc, magnesium, and iron, supporting immune balance and detoxification. ## Dosage & Preparation - Traditional Use: Traditionally crushed and applied to wounds and stings, infused for fevers and digestive discomfort, or used in steam for respiratory relief. Used ceremonially in Aboriginal and Māori healing. - Modern Use: Incorporated into detox teas, [anti-inflammatory](/ingredients/condition/inflammation) tinctures, skin balms, and herbal steams. - Dosage: 1–2 teaspoons dried leaf for infusion daily or 300–600 mg standardized extract daily. ## Safety & Drug Interactions No specific safety data, drug interactions, or contraindications have been established for Dodonaea viscosa leaf in human studies. High tannin and saponin content may potentially cause gastrointestinal upset, though specific toxicity thresholds remain unquantified. Preclinical animal models suggest low acute toxicity with tissue-protective rather than adverse effects observed. Pregnant and lactating women should avoid use due to insufficient safety data, and patients taking anticoagulant medications should exercise caution given the herb's [anti-inflammatory](/ingredients/condition/inflammation) properties. ## Scientific Research Research, including in vitro and animal studies, supports Dodonaea Leaf's [anti-inflammatory](/ingredients/condition/inflammation), [antimicrobial](/ingredients/condition/immune-support), and [antioxidant](/ingredients/condition/antioxidant) properties. Studies have investigated its potential for wound healing, pain reduction, and [liver detox](/ingredients/condition/detox)ification. Further human clinical trials are needed to confirm these traditional uses and establish optimal therapeutic applications. ## Historical & Cultural Context In Indigenous Australian and Māori traditions, Dodonaea Leaf is known as a purifier and spiritual protector. It was burned in rituals, applied for emotional and physical healing, and revered as a fortifier of body and spirit, symbolizing resilience and elemental balance across generations. ## Synergistic Combinations Role: Polyphenol/[antioxidant](/ingredients/condition/antioxidant) base Intention: Detox & Liver | Immune & [Inflammation](/ingredients/condition/inflammation) Primary Pairings: - Ginger (Zingiber officinale) - Turmeric (Curcuma longa) - Olive Oil (Olea europaea) - Lemongrass (Cymbopogon citratus) ## Frequently Asked Questions ### What are the main active compounds in Dodonaea leaf? Dodonaea viscosa leaf contains flavonoids including kaempferol, quercetin, and apigenin, along with tannins, saponins, phenols, triterpenoids, and steroids. Ethanolic extracts yield the highest concentrations of bioactive alkaloids, volatile oils, and flavonoids with demonstrated antimicrobial properties. ### Is there clinical evidence for Dodonaea leaf benefits? Currently no human clinical trials exist for Dodonaea viscosa leaf, with evidence limited to preclinical in vitro and animal studies. Animal studies show promise for liver protection and anti-inflammatory effects, but human trials are needed to establish therapeutic efficacy and safety profiles. ### How does Dodonaea leaf work for inflammation? Dodonaea leaf compounds inhibit lipoxygenase enzymes and reduce inflammatory mediators including nitric oxide, PGE2, and TNF-α in activated immune cells. The flavonoid viscosine specifically targets lipoxygenase through molecular binding mechanisms to modulate inflammatory pathways. ### What is the recommended dosage for Dodonaea leaf? No standardized human dosage has been established for Dodonaea viscosa leaf due to lack of clinical trials. Traditional preparations vary widely, and consultation with qualified healthcare practitioners is essential before use given the absence of safety and efficacy data in humans. ### Can Dodonaea leaf interact with medications? Specific drug interactions for Dodonaea viscosa leaf remain unknown due to insufficient research. However, its anti-inflammatory and antioxidant properties may theoretically interact with anticoagulant medications, requiring medical supervision and potential monitoring of bleeding parameters. ### Is Dodonaea leaf safe for pregnant women or nursing mothers? While Dodonaea leaf has been used traditionally in various cultures, there is limited clinical data on its safety during pregnancy and lactation. Pregnant and nursing women should consult with a healthcare provider before using Dodonaea leaf supplements to ensure it does not interfere with fetal development or pass into breast milk in concerning amounts. Traditional use does not guarantee safety in all populations, making professional guidance essential for this demographic. ### What is the best form of Dodonaea leaf supplement—extract, powder, or tea? Standardized extracts typically offer higher bioavailability and concentrated active compounds compared to raw powder or loose leaf tea. Tea forms allow for easier preparation and gentler consumption, though they may deliver lower concentrations of active constituents. The optimal form depends on individual preferences, digestive tolerance, and whether you seek rapid absorption or gradual delivery of the herb's benefits. ### Who should avoid Dodonaea leaf supplementation? Individuals with known allergies to Dodonaea or related plant species, as well as those with severe liver or kidney disease, should avoid supplementation without medical clearance. People taking blood thinners, immunosuppressants, or medications metabolized by the liver should consult a healthcare provider due to potential interaction risks. Additionally, children and pregnant women should seek professional guidance before use due to insufficient safety data in these populations. ## References Sources: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4284209; https://www.sciencedirect.com/science/article/pii/S0378874118302479; https://pubmed.ncbi.nlm.nih.gov/25498777 --- *Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com* *License: CC BY-NC-SA 4.0 — Attribution required. Commercial use: admin@hermeticasuperfoods.com*