Oil & Fat · Other

DGLA (Dihomo-Gamma-Linolenic Acid)

Provisional Moderate Scorelipid

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

DGLA (Dihomo-Gamma-Linolenic Acid) is an omega-6 fatty acid that produces anti-inflammatory prostaglandin E1 (PGE1) through cyclooxygenase conversion. Unlike other omega-6 fatty acids, DGLA reduces inflammation by competing with arachidonic acid for enzyme binding sites.

—

Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryOil & Fat

GroupOther

Public Score StatusProvisional Moderate

Primary KeywordDGLA benefits

DGLA close-up macro showing natural texture and detail — rich in anti-inflammatory, immunomodulatory, lipid-lowering

DGLA (Dihomo-Gamma-Linolenic Acid) — botanical close-up

Reported Benefits (Provisional)

Supports anti-inflammatory responses in the body

DGLA reduces inflammatory markers by up to 30%, promoting overall wellness. - Aids in maintaining joint health and reducing pain. It decreases joint inflammation, enhancing mobility and comfort. - Supports skin health by reducing acne and improving texture. DGLA's anti-inflammatory properties soothe and smooth the skin. - Enhances immune system function. It boosts the production of anti-inflammatory cytokines, strengthening defenses. - Supports cardiovascular health by improving blood vessel function. DGLA helps maintain healthy blood pressure levels. - May assist in managing symptoms of PMS. It regulates prostaglandin production, reducing menstrual discomfort. - Promotes mental well-being by supporting neurotransmitter function. DGLA aids in mood regulation and cognitive clarity.

Origin & History

Natural habitat

DGLA, or dihomo-gamma-linolenic acid, is an omega-6 fatty acid found in small amounts in animal fats and some plant oils. It is produced in the body from GLA and plays a role in anti-inflammatory processes.

“DGLA has been less studied than other omega-6 fatty acids but is gaining attention for its unique properties and potential health benefits.”Traditional Medicine

Research Narrative (Provisional)

Preliminary research, including in vitro studies, suggests DGLA's potential in supporting anti-inflammatory and cardiovascular health. Its role in the metabolism of GLA is being explored.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Contains omega-6 fatty acids, particularly DGLA. - Acts as an intermediate in the metabolism of GLA. - Found in small amounts in animal fats and some plant oils.

Reported Mechanism (Provisional)

Mechanism of Action

DGLA converts to prostaglandin E1 (PGE1) via cyclooxygenase-1 and cyclooxygenase-2 enzymes, producing anti-inflammatory effects. It competes with arachidonic acid for delta-5 desaturase enzyme binding, reducing pro-inflammatory arachidonic acid metabolism. DGLA also activates peroxisome proliferator-activated receptor gamma (PPAR-γ), further suppressing inflammatory gene expression.

Clinical Narrative (Provisional)

Small-scale studies with 20-60 participants show DGLA supplementation reduces inflammatory markers like IL-6 and TNF-α by 20-30% over 8-12 weeks. Clinical trials in rheumatoid arthritis patients demonstrate modest improvements in joint pain scores and morning stiffness. However, most research consists of pilot studies rather than large randomized controlled trials. Evidence is promising but requires larger, longer-term studies to establish definitive therapeutic benefits.

Also Known As

8,11,14-Eicosatrienoic acid20:3(n-6)Homo-gamma-linolenic acidDGLAEicosatrienoic acidDihomo-GLA

Browse All Ingredients More Other About the Encyclopedia

These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

From the Hermetica Research Desk

Research updates — and 25% off your first order

Join our list for source-aware wellness education, review-state updates, and product news — and unlock 25% off your first Hermetica order. Educational content is not medical advice. No spam, unsubscribe anytime.

Educational content only — not medical advice.