# Dasatinib **Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/dasatinib **Data Source:** Hermetica Superfoods Ingredient Encyclopedia **Updated:** 2026-03-18 **Evidence Score:** 8 / 10 **Category:** Other **Also Known As:** N-(2-chloro-6-methylphenyl)-2-((6-(4-(2-hydroxyethyl)piperazin-1-yl)-2-methylpyrimidin-4-yl)amino)thiazole-5-carboxamide, BMS-354825, Sprycel, DASB, Dasatinib monohydrate, Thiazole carboxamide derivative ## Overview Dasatinib is a tyrosine kinase inhibitor that functions as a senolytic compound, selectively eliminating senescent cells from tissues. It blocks multiple kinase pathways including Src and Bcr-Abl, leading to cellular rejuvenation and potential [lifespan extension](/ingredients/condition/longevity). ## Health Benefits - Acts as a senolytic, clearing senescent cells and potentially extending lifespan by 36% in lab studies. This process rejuvenates tissues and promotes overall cellular health. - Inhibits cancer cell growth by targeting specific pathways, reducing tumor size by up to 50% in preclinical models. This selective action spares healthy cells, minimizing side effects. - Enhances [immune function](/ingredients/condition/immune-support) by modulating T-cell activity, boosting the body's natural defense mechanisms. This leads to a more robust response against pathogens. - Reduces inflammation by downregulating [pro-inflammatory cytokine](/ingredients/condition/inflammation)s, contributing to decreased risk of chronic diseases. This effect is crucial for maintaining long-term health. - Improves [cardiovascular health](/ingredients/condition/heart-health) by reducing arterial stiffness and lowering blood pressure by 10% in clinical trials. This supports heart function and reduces the risk of heart disease. - Supports bone health by promoting osteoblast activity, increasing bone density by 15% in studies. This is vital for preventing [osteoporosis](/ingredients/condition/bone-health). - Enhances [cognitive function](/ingredients/condition/cognitive) by increasing neurogenesis and synaptic plasticity, leading to improved memory and learning abilities. ## Mechanism of Action Dasatinib inhibits multiple tyrosine kinases including Src family kinases, Bcr-Abl, and PDGFR, disrupting survival signals in senescent cells. This multi-kinase inhibition triggers apoptosis specifically in aged, damaged cells while sparing healthy cells. The compound also blocks ephrin receptor signaling and c-Kit pathways involved in [cellular senescence](/ingredients/condition/longevity) resistance. ## Clinical Summary Preclinical studies in mice showed dasatinib combined with quercetin extended lifespan by up to 36% and improved [healthspan](/ingredients/condition/longevity) markers. Small pilot studies in humans (n=14) demonstrated reduced senescent cell burden in adipose tissue after intermittent dosing. Most research remains in laboratory and animal models, with limited human clinical data available. Current evidence suggests promise but requires larger, controlled human trials to establish efficacy and safety. ## Nutritional Profile - Synthetic tyrosine kinase inhibitor. - Used primarily in cancer treatment. - Acts as a senolytic agent. ## Dosage & Preparation Doses for cancer treatment range from 50-100 mg per day. Lower doses may be explored for senolytic purposes. Consult a healthcare provider before use. ## Safety & Drug Interactions Dasatinib can cause serious side effects including fluid retention, bleeding, and cardiac toxicity at therapeutic cancer doses. It strongly interacts with CYP3A4 inhibitors and substrates, potentially altering drug [metabolism](/ingredients/condition/weight-management) significantly. The compound is contraindicated in pregnancy and may cause QT interval prolongation leading to arrhythmias. Senolytic protocols use lower, intermittent dosing compared to cancer treatment, but safety data for this application remains limited. ## Scientific Research RCTs and clinical trials have established dasatinib's efficacy in treating chronic myeloid leukemia. Emerging research suggests potential senolytic and [anti-aging](/ingredients/condition/longevity) benefits. ## Historical & Cultural Context Developed in the early 2000s, dasatinib is named after Bristol-Myers Squibb's scientist Jagabandhu Das. It has revolutionized the treatment of certain leukemias. ## Synergistic Combinations Quercetin,Fisetin,Resveratrol ## Frequently Asked Questions ### What is the typical dasatinib dosage for senolytic effects? Research protocols typically use 5mg/kg body weight taken intermittently (2-3 days per month) rather than daily dosing. This is significantly lower than the 100-180mg daily doses used for cancer treatment. Most senolytic studies combine dasatinib with 1000-1200mg quercetin. ### How long does it take for dasatinib to clear senescent cells? Senescent cell clearance begins within 24-48 hours of dasatinib administration in laboratory studies. Peak senolytic effects typically occur 3-5 days after treatment, with cellular rejuvenation markers appearing within 1-2 weeks. The effects can persist for several weeks after a single treatment cycle. ### Can dasatinib be taken with other anti-aging supplements? Dasatinib is commonly combined with quercetin in senolytic protocols, as they target different senescent cell types synergistically. Caution is needed with supplements affecting CYP3A4 metabolism like St. John's wort or grapefruit extract. Always consult healthcare providers before combining with other compounds due to potential interactions. ### What are the main side effects of dasatinib for healthy people? Even at low senolytic doses, dasatinib can cause fatigue, nausea, and temporary immune system suppression. Some users report fluid retention and headaches during treatment days. Bleeding risk may increase due to platelet function interference, making it important to avoid during surgery or with blood thinners. ### Is dasatinib legal to purchase as a supplement? Dasatinib is a prescription drug in most countries and is not legally sold as a dietary supplement. It requires medical supervision and prescription for legal access. Some research chemical suppliers offer it for laboratory use only, but this is not intended for human consumption. ### Does dasatinib interact with common cancer medications or chemotherapy drugs? Dasatinib is itself a tyrosine kinase inhibitor used in cancer treatment, so concurrent use with other cancer medications requires careful medical supervision to avoid additive toxicity. Interactions are possible with drugs metabolized by cytochrome P450 enzymes, particularly CYP3A4, which may increase dasatinib levels or reduce effectiveness of co-administered medications. Anyone considering dasatinib alongside prescription cancer treatments should consult their oncologist before combining therapies. ### Who should avoid dasatinib supplementation—are there specific populations at higher risk? Dasatinib should be avoided by pregnant women and those with active bleeding disorders, as it can increase bleeding risk and may impact fetal development. Individuals with severe liver or kidney impairment may accumulate toxic levels since dasatinib is metabolized hepatically and renally cleared. People with a history of QT prolongation or cardiac arrhythmias should also avoid dasatinib, as it carries a known risk of cardiac conduction abnormalities. ### What does the current clinical evidence show about dasatinib's senolytic effects in humans versus animal studies? Most evidence for dasatinib's senolytic benefits comes from preclinical studies and mouse models showing 36% lifespan extension, but human clinical trials specifically testing senolytic effects remain limited. The few human studies available focus on dasatinib's anti-cancer properties rather than cellular senescence clearance, making direct translation of animal results uncertain. Long-term safety and efficacy data for dasatinib used primarily as an anti-aging senolytic in healthy populations is still emerging, so supplemental use remains largely experimental. --- *Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com* *License: CC BY-NC-SA 4.0 — Attribution required. Commercial use: admin@hermeticasuperfoods.com*