Extract & Compound · Compound

Cyanidin-3-Glucoside (C3G)

Provisional Moderate Scorecompound

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Cyanidin-3-glucoside (C3G) is an anthocyanin polyphenol that provides potent antioxidant protection through its ability to neutralize free radicals and reduce oxidative stress. It works primarily by activating cellular antioxidant enzymes and protecting mitochondrial function.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryExtract & Compound

GroupCompound

Public Score StatusProvisional Moderate

Primary Keywordcyanidin-3-glucoside benefits

Cyanidin-3-Glucoside close-up macro showing natural texture and detail — rich in antioxidant, anti-inflammatory, neuroprotective

Cyanidin-3-Glucoside (C3G) — botanical close-up

Reported Benefits (Provisional)

Cyanidin-3-Glucoside (C3G) is a potent antioxidant that protects cells from oxidative damage, helping to prevent chronic diseases. Its action supports overall cellular health. - C3G supports eye health by enhancing blood flow to the retina, potentially improving vision and reducing the risk of age-related macular degeneration. - It aids in weight management by promoting fat oxidation and reducing fat accumulation, contributing to a healthier body composition. - C3G supports cardiovascular health by improving endothelial function, which enhances blood circulation and reduces the risk of heart disease. - It promotes anti-inflammatory effects by inhibiting pro-inflammatory pathways, which can alleviate symptoms of inflammatory conditions. - C3G enhances cognitive function by protecting neurons from oxidative stress, potentially reducing the risk of neurodegenerative diseases. - It supports skin health by reducing UV-induced damage and boosting collagen production, leading to firmer and more resilient skin.

Origin & History

Natural habitat

Cyanidin-3-Glucoside (C3G) is an anthocyanin found in dark-colored fruits like blackberries and black rice. It is extracted through solvent extraction to concentrate the active compound.

“C3G has been consumed in traditional diets rich in berries and dark-colored grains, known for their health benefits.”Traditional Medicine

Research Narrative (Provisional)

In vitro and animal studies demonstrate C3G's antioxidant and eye health benefits. Human studies are limited but promising for cognitive and cardiovascular support.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Rich in anthocyanins, particularly C3G. - Contains other polyphenols and antioxidants. - Low in calories and free from fats.

Reported Mechanism (Provisional)

Mechanism of Action

Cyanidin-3-glucoside activates nuclear factor erythroid 2-related factor 2 (Nrf2), which upregulates antioxidant enzymes including superoxide dismutase and catalase. It also inhibits pro-inflammatory pathways by suppressing nuclear factor-kappa B (NF-κB) activation and reducing inflammatory cytokine production. Additionally, C3G stabilizes collagen and improves capillary integrity through anthocyanoside accumulation in vascular tissues.

Clinical Narrative (Provisional)

Human studies on C3G are limited, with most evidence coming from animal models and in vitro research. A 12-week randomized controlled trial with 48 participants showed that 320mg daily of anthocyanin extract containing C3G improved visual fatigue scores by 23%. Rodent studies demonstrate improved insulin sensitivity and reduced inflammation at doses equivalent to 50-100mg daily in humans. However, large-scale human trials are needed to establish definitive therapeutic benefits and optimal dosing protocols.

Also Known As

Cyanidin 3-O-glucosideC3GCyanidin-3-O-β-D-glucopyranosideKuromaninChrysantheminCyanidin 3-glucosideAnthocyanidin glucoside

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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