# Cudrania Tricuspidata **Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/cudrania-tricuspidata **Data Source:** Hermetica Superfoods Ingredient Encyclopedia **Updated:** 2026-03-15 **Evidence Score:** 4 / 10 **Category:** Fruit **Also Known As:** Maclura tricuspidata, Che, Silkworm Thorn ## Overview Cudrania tricuspidata fruit is rich in flavonoids and phenolic compounds, which contribute to its potent [antioxidant activity](/ingredients/condition/antioxidant) by combating oxidative stress. It also exhibits [anti-inflammatory](/ingredients/condition/inflammation) responses through the inhibition of pro-inflammatory mediators. ## Health Benefits - Exhibits potent [antioxidant activity](/ingredients/condition/antioxidant) with high concentrations of flavonoids and phenolic compounds, combating oxidative stress and supporting cellular protection. - Supports [anti-inflammatory](/ingredients/condition/inflammation) responses by inhibiting pro-inflammatory mediators and modulating immune signaling pathways. - Demonstrates antidiabetic effects through the regulation of glucose metabolism and enhancement of [insulin sensitivity](/ingredients/condition/weight-management). - Possesses anticancer potential by inducing apoptosis in cancer cells and inhibiting tumor growth in vitro and in vivo models. - Modulates [immune function](/ingredients/condition/immune-support), contributing to overall resilience against various conditions. ## Mechanism of Action Cudrania tricuspidata exerts its health benefits primarily through the action of its rich flavonoid and phenolic content. These compounds combat [oxidative stress](/ingredients/condition/antioxidant) by neutralizing free radicals, thereby supporting cellular protection. Furthermore, the fruit's extracts are understood to support [anti-inflammatory](/ingredients/condition/inflammation) responses by inhibiting pro-inflammatory mediators and modulating immune signaling pathways. ## Clinical Summary Extensive research supports the phytochemistry and pharmacological effects of Cudrania tricuspidata, primarily demonstrated through in vitro and in vivo studies. Bioactivity validation in [antioxidant](/ingredients/condition/antioxidant) and [anti-inflammatory](/ingredients/condition/inflammation) models confirms its therapeutic potential in these areas. While these studies highlight promising effects, specific human clinical trial data, including study types, sample sizes, and detailed outcomes, are not provided in the available information. ## Nutritional Profile - Flavonoids: Including kaempferol and quercetin, providing potent [antioxidant protection](/ingredients/condition/antioxidant). - Phenolic Acids: Such as chlorogenic acid, contributing to antioxidant and [anti-inflammatory](/ingredients/condition/inflammation) effects. - Xanthones: Offer antioxidant and cytoprotective properties. - Polysaccharides: Support immune and metabolic function. - Vitamins and Essential Minerals: Contribute to overall [immune support](/ingredients/condition/immune-support) and metabolic health. ## Dosage & Preparation - Forms: Fresh fruit, processed fruit (juice, wine), decoctions, infusions (from roots, leaves, bark, stems). - Traditional Use: Employed in East Asian medicine for [inflammatory](/ingredients/condition/inflammation) and infectious diseases. - Modern Applications: Utilized in functional foods, dietary supplements, and herbal remedies for chronic conditions. - Dosage: Consume fresh or processed fruit as part of a balanced diet; for medicinal use, consult a healthcare practitioner. ## Safety & Drug Interactions Information regarding the specific safety profile, potential side effects, drug interactions, or contraindications for Cudrania tricuspidata fruit, particularly concerning pregnancy or breastfeeding, is not provided in the available research. As with any natural product, individuals should consult a healthcare professional before use, especially those with existing medical conditions or those taking other medications. ## Scientific Research Extensive research supports Cudrania tricuspidata's phytochemistry and pharmacological effects, with studies detailing its therapeutic potential. Bioactivity validation in [antioxidant](/ingredients/condition/antioxidant) and [anti-inflammatory](/ingredients/condition/inflammation) models further confirms its health benefits. ## Historical & Cultural Context Deeply woven into the healing traditions of East Asia, Cudrania tricuspidata has served as a botanical remedy for diverse ailments for centuries. It bridges ancient wisdom with emerging biomedical interest in its potent therapeutic compounds for conditions like eczema, mumps, and arthritis. ## Synergistic Combinations Role: Polyphenol/[antioxidant](/ingredients/condition/antioxidant) base Intention: Immune & [Inflammation](/ingredients/condition/inflammation) | Energy & [Metabolism](/ingredients/condition/weight-management) Primary Pairings: - Turmeric (Curcuma longa) - Camu Camu (Myrciaria dubia) - Ginger (Zingiber officinale) - Maca Root (Lepidium meyenii) ## Frequently Asked Questions ### What are the main health benefits of Cudrania tricuspidata fruit? Cudrania tricuspidata fruit exhibits potent antioxidant activity due to high concentrations of flavonoids and phenolic compounds, which help combat oxidative stress and support cellular protection. It also supports anti-inflammatory responses by inhibiting pro-inflammatory mediators and modulating immune signaling pathways. ### What are the primary bioactive compounds responsible for its effects? The primary bioactive compounds in Cudrania tricuspidata fruit are recognized as flavonoids and phenolic compounds. These compounds are responsible for its observed antioxidant and anti-inflammatory properties, although specific detailed mechanisms beyond general pathways are not extensively elaborated in the provided information. ### Where does Cudrania tricuspidata originate? Cudrania tricuspidata, also known as Che or Silkworm Thorn, is a fruit-bearing tree native to East Asia. It thrives particularly in the temperate forested and hilly regions of countries like China, Korea, and Japan. ### What are other names for Cudrania tricuspidata? Cudrania tricuspidata is also scientifically known as Maclura tricuspidata. Common names include Che and Silkworm Thorn, reflecting its traditional uses and characteristics. ### Is there any information about the safety, side effects, or drug interactions of Cudrania tricuspidata? The provided research does not contain specific details regarding the safety profile, potential side effects, drug interactions, or contraindications for Cudrania tricuspidata fruit. It is always recommended to consult a healthcare professional before incorporating any new supplement, especially if pregnant, breastfeeding, or taking other medications. ### What is the most bioavailable form of Cudrania tricuspidata, and how does extraction method affect its potency? Standardized fruit extracts that concentrate the flavonoid and phenolic compounds demonstrate superior bioavailability compared to whole fruit powder, as extraction processes isolate the active constituents for better absorption. Cold-water extraction methods and ethanol-based extracts tend to preserve the delicate polyphenol structures more effectively than heat-based processing, which can degrade sensitive bioactive compounds. The standardization to specific flavonoid percentages (typically 10-30%) ensures consistent potency across supplement batches and more predictable physiological effects. ### Who benefits most from Cudrania tricuspidata supplementation, and are there specific populations who should avoid it? Individuals with elevated oxidative stress markers, inflammatory conditions, or prediabetic/diabetic metabolic profiles may benefit most from Cudrania tricuspidata's antioxidant and glucose-regulating properties. Those with bleeding disorders or taking anticoagulant medications should exercise caution, as high-dose phenolic compounds may potentiate bleeding risk. Pregnant and nursing women should consult healthcare providers before supplementation, as safety data in these populations remains limited. ### How does the clinical research quality for Cudrania tricuspidata compare to other antioxidant fruits, and what evidence gaps exist? Most evidence for Cudrania tricuspidata comes from in vitro and animal studies demonstrating potent antioxidant and anti-inflammatory mechanisms, though human clinical trials remain sparse compared to extensively researched berries like blueberries or pomegranate. The existing research strongly supports its bioactive compound profile and theoretical benefits, but well-designed randomized controlled trials in human populations with specific health endpoints (glucose control, inflammatory markers) are needed to establish clinical efficacy. This ingredient represents a promising traditional botanical with compelling mechanistic support but requires more rigorous human evidence for definitive clinical recommendations. ## References Sources: https://pubs.rsc.org/en/content/articlehtml/2017/ra/c7ra04322h; https://www.nature.com/research-intelligence/cudrania-tricuspidata-and-its-therapeutic-potential; https://www.mdpi.com/2304-8158/12/11/2146 --- *Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com* *License: CC BY-NC-SA 4.0 — Attribution required. Commercial use: admin@hermeticasuperfoods.com*