Mushroom · Mushroom/Fungi

Cordycepin (3'-Deoxyadenosine)

Provisional Moderate Scorecompound

Hermetica Superfood Encyclopedia

Published March 18, 2026Last updated March 18, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Cordycepin (3'-deoxyadenosine) is a nucleoside analog derived from Cordyceps militaris mushrooms that modulates cellular signaling pathways. It supports immune function through enhanced natural killer cell activity and exhibits anti-inflammatory effects by inhibiting NF-κB and MAPK signaling cascades.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryMushroom

GroupMushroom/Fungi

Public Score StatusProvisional Moderate

Primary Keywordcordycepin benefits

Cordycepin close-up macro showing natural texture and detail — rich in antitumor, antioxidant, anti-inflammatory

Cordycepin (3'-Deoxyadenosine) — botanical close-up

Reported Benefits (Provisional)

Supports immune function by enhancing the activity of natural killer cells, improving the body's defense against infections. - Exhibits anti-inflammatory properties by inhibiting pro-inflammatory cytokines, reducing chronic inflammation. - Promotes cardiovascular health by improving blood circulation, reducing the risk of heart disease. - Enhances energy levels by increasing ATP production, boosting physical performance and endurance. - Supports respiratory health by reducing symptoms of asthma and other respiratory conditions. - Improves cognitive function by protecting neurons from oxidative stress, potentially enhancing memory and focus. - Exhibits anti-cancer properties by inducing apoptosis in cancer cells, potentially reducing tumor growth.

Origin & History

Natural habitat

Cordycepin, also known as 3'-Deoxyadenosine, is a bioactive compound extracted from the Cordyceps militaris mushroom. It is typically produced through a fermentation process or direct extraction from the fruiting bodies of the mushroom.

“Cordyceps has been used for centuries in traditional Chinese medicine as a tonic for longevity and vitality. Its discovery is rooted in the observation of its effects on livestock grazing on the fungi.”Traditional Medicine

Research Narrative (Provisional)

Cordycepin has been studied in various in vitro and animal models, with emerging evidence from small human trials suggesting its potential therapeutic benefits. More extensive RCTs are needed to confirm these effects.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Contains nucleoside analogs with potential therapeutic effects. - Rich in antioxidants that combat oxidative stress. - Provides essential amino acids and polysaccharides.

Reported Mechanism (Provisional)

Mechanism of Action

Cordycepin functions as an adenosine analog, inhibiting adenosine receptors and disrupting RNA synthesis through premature chain termination. It suppresses inflammatory pathways by blocking NF-κB and MAPK activation, while enhancing immune responses through stimulation of natural killer cells and T-lymphocyte proliferation. The compound also modulates AMPK signaling, contributing to metabolic and cardiovascular benefits.

Clinical Narrative (Provisional)

Human studies on cordycepin remain limited, with most evidence derived from animal models and in vitro research. Small clinical trials (n=20-60) have shown improvements in immune markers and exercise performance with Cordyceps extracts containing cordycepin. Animal studies demonstrate significant anti-inflammatory effects and enhanced immune function at doses of 10-50 mg/kg body weight. The current evidence is promising but requires larger, well-controlled human trials to establish therapeutic efficacy.

Also Known As

3'-DeoxyadenosineCordyceps nucleosideDong Chong Xia Cao compoundMilitaris extract3'-dACaterpillar fungus nucleosideWinter worm summer grass compound

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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