# Complanatoside **Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/complanatoside **Data Source:** Hermetica Superfoods Ingredient Encyclopedia **Updated:** 2026-03-30 **Evidence Score:** 2 / 10 **Category:** Compound **Also Known As:** Complanatoside A, Flavonoid glycoside C27H30O18, Cynanchum glycoside, Chromen-4-one diglucoside ## Overview Complanatoside is a flavonoid glycoside isolated primarily from Astragalus complanatus, structurally characterized as a kaempferol-based glycoside. Research on its pharmacological properties remains extremely limited, with no peer-reviewed studies establishing mechanisms of action or therapeutic applications. ## Health Benefits • No documented health benefits - PubChem reports 0 literature references • No clinical evidence from human trials exists • No pharmacological mechanisms have been studied • No traditional medicinal uses are documented • No biomedical applications have been investigated ## Mechanism of Action Complanatoside belongs to the kaempferol glycoside class, suggesting a theoretical capacity to interact with antioxidant pathways common to flavonoids, such as Nrf2 signaling or [free radical scaveng](/ingredients/condition/antioxidant)ing via hydroxyl groups on the phenolic ring. However, no published studies have characterized its binding to specific receptors, enzymes, or signaling proteins. Any mechanistic claims would be speculative extrapolations from structurally related compounds rather than direct experimental evidence. ## Clinical Summary As of current literature, zero human clinical trials, animal pharmacology studies, or in vitro mechanistic investigations specific to complanatoside have been published, as reflected by PubChem's report of 0 literature references for this compound. No dose-response data, bioavailability measurements, or efficacy endpoints have been established. The absence of any preclinical data means evidence strength cannot be rated; it is simply nonexistent. Researchers have not yet investigated this compound in any documented biomedical context. ## Nutritional Profile Complanatoside is a flavonoid glycoside (specifically a flavonol glycoside) compound, not a food ingredient or nutritional source. It is chemically identified as a kaempferol-based glycoside isolated from plants such as Astragalus complanatus. As a pure isolated compound, it contains no macronutrients (0g protein, 0g fat, 0g dietary fiber in isolated form). Its molecular structure (C27H30O15, molecular weight approximately 594.52 g/mol) consists of a kaempferol aglycone core with attached sugar moieties. As a flavonoid, it belongs to the broader class of polyphenolic bioactive compounds. No nutritional concentration data exists in standardized food composition databases such as USDA FoodData Central or EFSA, as it is not consumed as a standalone nutrient. Trace amounts may be present in Astragalus complanatus seeds, though precise concentration data in plant material is not established in peer-reviewed nutritional literature. Bioavailability data is entirely absent; however, by structural analogy to similar flavonol glycosides, intestinal hydrolysis to release the kaempferol aglycone is plausible prior to absorption, though this remains unconfirmed for complanatoside specifically. ## Dosage & Preparation No clinically studied dosage ranges, forms, or standardization details are documented as no human studies are available. Safety data is completely absent, including contraindications and toxicity profiles. Consult a healthcare provider before starting any new supplement. ## Safety & Drug Interactions No safety profile, toxicology data, or adverse event reports exist for complanatoside in published scientific literature. Drug interaction potential is entirely unknown, as no studies have examined its [metabolism](/ingredients/condition/weight-management) via cytochrome P450 enzymes or transporter proteins such as P-glycoprotein. Contraindications for pregnant or breastfeeding individuals cannot be established due to a complete absence of reproductive toxicity data. Consumers should treat this compound as uninvestigated and consult a healthcare provider before use. ## Scientific Research No clinical trials, randomized controlled trials, or meta-analyses exist for Complanatoside A. PubChem reports 0 literature references and no associated PMIDs for biomedical applications. The compound lacks any documented research beyond basic chemical characterization. ## Historical & Cultural Context No information on traditional medicinal uses, historical context, or traditional medicine systems (Ayurveda, TCM) is available. The compound appears to be primarily a research-grade phytochemical without established traditional applications. ## Synergistic Combinations No synergistic combinations documented ## Frequently Asked Questions ### What is complanatoside and where does it come from? Complanatoside is a flavonoid glycoside structurally related to kaempferol, identified as a constituent of Astragalus complanatus, a plant used in traditional Chinese herbalism. It belongs to the broader class of glycosides in which a sugar moiety is bound to a flavonoid aglycone. No commercial supplement products have been documented to use complanatoside as an isolated, standardized ingredient. ### Are there any proven health benefits of complanatoside? No proven health benefits of complanatoside have been documented in any peer-reviewed publication. PubChem lists zero literature references for this compound, meaning no clinical trials, animal studies, or cell-based experiments have been published to support any therapeutic claim. Any benefit attributed to it would be unsupported speculation. ### Is complanatoside safe to take as a supplement? The safety of complanatoside as a supplement is entirely unknown due to the absence of toxicology, pharmacokinetic, or human safety studies. No LD50 values, no-observed-adverse-effect levels, or clinical adverse event data have been reported. Until foundational safety research is conducted, its use cannot be considered evidence-based or reliably safe. ### How is complanatoside different from other flavonoid glycosides like astragalin? Complanatoside and astragalin are both kaempferol-based glycosides found in Astragalus species, but they differ in their sugar substituents and attachment positions on the flavonoid backbone. Astragalin (kaempferol-3-O-glucoside) has documented antioxidant and anti-inflammatory activity in published studies, whereas complanatoside has no comparable research record. This distinction makes astragalin a studied compound and complanatoside an essentially uncharacterized one. ### Does complanatoside appear in any dietary supplements on the market? Complanatoside does not appear as a labeled, isolated ingredient in any widely documented dietary supplement product. Some Astragalus complanatus seed extracts may incidentally contain trace amounts of complanatoside alongside better-studied constituents like astragalosides and flavonoids. No supplement manufacturer has standardized a product to a specific complanatoside content based on available records. ### What is the current research status and evidence quality for complanatoside? Complanatoside currently has no published clinical research or human trials investigating its effects. PubChem records indicate zero literature references for this compound, meaning its pharmacological mechanisms, bioavailability, and safety profile in humans remain completely unstudied. Any health claims about complanatoside would be unsupported by scientific evidence at this time. ### Are there any known food sources where complanatoside naturally occurs? While complanatoside is a flavonoid glycoside that may theoretically occur in plants, no specific dietary sources have been identified or documented in scientific literature. The compound's presence in foods has not been systematically investigated or characterized, making it impossible to recommend dietary sources as a natural way to obtain it. ### Why is complanatoside not widely available in commercial supplements despite being a named bioactive compound? Complanatoside lacks the clinical evidence, documented health benefits, and traditional use history that typically drive supplement development and commercialization. Without established safety data, efficacy studies, or known applications, manufacturers have little scientific or commercial justification to isolate and market this compound as a supplement ingredient. --- *Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com* *License: CC BY-NC-SA 4.0 — Attribution required. 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