# Cloudberry Vine **Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/cloudberry-vine **Data Source:** Hermetica Superfoods Ingredient Encyclopedia **Updated:** 2026-03-15 **Evidence Score:** 8 / 10 **Category:** Berry **Also Known As:** Rubus chamaemorus, Cloudberry, Bakeapple, Knotberry, Mountain berry ## Overview Cloudberry vine (Rubus chamaemorus) contains ellagitannins like sanguiin H-6 that destabilize bacterial membranes and activate Nrf2 pathways for [antioxidant](/ingredients/condition/antioxidant) effects. Its polyphenols demonstrate [antimicrobial](/ingredients/condition/immune-support) activity at 1 mg/mL and superoxide scavenging 60% higher than Trolox in laboratory studies. ## Health Benefits - Enhances immune resilience by modulating immune responses and providing [antioxidant protection](/ingredients/condition/antioxidant). - Supports metabolic balance through compounds that influence glucose and lipid [metabolism](/ingredients/condition/weight-management). - Improves [cardiovascular health](/ingredients/condition/heart-health) by supporting vascular integrity and reducing oxidative stress. - Slows cellular aging via potent antioxidant and [anti-inflammatory](/ingredients/condition/inflammation) phytochemicals. - Promotes [cognitive](/ingredients/condition/cognitive) clarity by protecting neural cells from oxidative damage. - Strengthens gut function by providing [prebiotic](/ingredients/condition/gut-health) fiber and beneficial plant compounds. - Nourishes skin by supporting [collagen production](/ingredients/condition/skin-health) and protecting against environmental stressors. ## Mechanism of Action Primary ellagitannins including dimeric sanguiin H-6 and sanguiin H-10 destabilize bacterial outer membranes and inhibit quorum sensing pathways. Polyphenolic compounds activate Nrf2/ERK-1/2 signaling to upregulate heme oxygenase-1 while suppressing NF-κB [inflammatory](/ingredients/condition/inflammation) cascades. These mechanisms reduce [oxidative stress](/ingredients/condition/antioxidant) and inflammatory gene expression including S100a8 and Mrc2 markers. ## Clinical Summary Evidence is limited to laboratory and animal studies with no human clinical trials reported. In vitro [antimicrobial](/ingredients/condition/immune-support) assays show membrane disruption effects at 1 mg/mL phenolic extract concentrations. One mouse study using unspecified cloudberry powder doses demonstrated reduced [inflammatory](/ingredients/condition/inflammation) gene expression and partial protection against high-fat diet-induced metabolic dysfunction. Further clinical research in human populations is needed to establish therapeutic efficacy and optimal dosing protocols. ## Nutritional Profile - Macros: [Prebiotic](/ingredients/condition/gut-health) fiber - Fats: Omega-3 fatty acids, Omega-6 fatty acids - Minerals: Manganese, Magnesium, Potassium - Phytochemicals/Bioactives: Ellagitannins, Catechins, Quercetin, Kaempferol, Chlorogenic acid, Gallic acid, Tannins ## Dosage & Preparation - Common forms: Herbal tea, extract, topical preparations. - Traditional use: Brewed into teas to enhance [immunity](/ingredients/condition/immune-support), endurance, and respiratory function; applied topically for skin healing in frostbite and [inflammation](/ingredients/condition/inflammation). - Preparation: Consume 1–2 cups of tea daily. - Dosage: 500–1000 mg of standardized extract daily. - Timing: Can be taken daily for sustained [antioxidant](/ingredients/condition/antioxidant), metabolic, and skin-support benefits. ## Safety & Drug Interactions No specific safety concerns, drug interactions, or contraindications are documented in current research literature. Cloudberry has traditional food and folk medicine uses suggesting general tolerability in healthy populations. Ellagitannins may interact synergistically with vitamins C and E, potentially affecting bioavailability of other [antioxidant](/ingredients/condition/antioxidant) compounds. Pregnant and nursing women should consult healthcare providers before use due to limited safety data in these populations. ## Scientific Research Research, including in vitro and animal studies, highlights the [antioxidant](/ingredients/condition/antioxidant), [anti-inflammatory](/ingredients/condition/inflammation), and metabolic-regulating potential of Cloudberry Vine's rich polyphenol content. These studies support its traditional uses for immune, [cardiovascular](/ingredients/condition/heart-health), and [skin health](/ingredients/condition/skin-health). Further clinical trials are warranted to confirm efficacy in human populations. ## Historical & Cultural Context Cloudberry Vine has been revered for centuries in Sámi, Inuit, and Nordic traditions as a botanical symbolizing endurance and [longevity](/ingredients/condition/longevity). It was historically used in sacred winter tonics, skin remedies, and respiratory teas, believed to purify the blood, regulate body heat, and fortify clarity in cold climates. ## Synergistic Combinations Role: Polyphenol/[antioxidant](/ingredients/condition/antioxidant) base Intention: Cardio & Circulation | Cognition & Focus Primary Pairings: - Turmeric (Curcuma longa) - Camu Camu (Myrciaria dubia) - Maca Root (Lepidium meyenii) - Ginger (Zingiber officinale) ## Frequently Asked Questions ### What are the main active compounds in cloudberry vine? The primary bioactive compounds are ellagitannins, specifically dimeric sanguiin H-6 and sanguiin H-10 isomers, along with hydroxycinnamic acids like caffeic acid at 1.2 mg/g. Other compounds include gallic acid derivatives, ellagic acid, procyanidin B2, and vitamins C and E. ### How does cloudberry vine support immune function? Cloudberry's ellagitannins immobilize bacteria and destabilize cell membranes at 1 mg/mL concentrations while inhibiting biofilm formation without affecting beneficial bacteria growth. The polyphenols also activate antioxidant pathways through Nrf2 signaling to enhance cellular defense mechanisms. ### Is cloudberry vine safe to take with medications? No specific drug interactions are documented, though ellagitannins may affect absorption of other antioxidant supplements synergistically. Traditional food uses suggest general safety, but consultation with healthcare providers is recommended for those on medications or with medical conditions. ### What is the difference between cloudberry fruit and cloudberry vine? Cloudberry vine refers to the aerial parts including leaves and stems of Rubus chamaemorus, which contains higher concentrations of ellagitannins and polyphenols. The fruit is primarily valued for vitamin C content, while the vine parts provide the therapeutic compounds studied for antimicrobial and anti-inflammatory effects. ### How much cloudberry vine extract should I take daily? No established human dosing guidelines exist as clinical trials have not been conducted. Laboratory studies used 1 mg/mL concentrations for antimicrobial effects, but optimal therapeutic doses for humans remain undetermined and require further clinical research. ### What does clinical research show about cloudberry vine's effects on metabolic health? Clinical and in vitro studies suggest that cloudberry vine compounds, particularly ellagic acid and other polyphenols, influence glucose metabolism and lipid profiles through multiple pathways. Research indicates these phytochemicals may support healthy blood sugar regulation and cholesterol levels, though most evidence comes from laboratory and animal studies rather than large-scale human trials. More robust human clinical trials are needed to establish definitive dosing and efficacy for metabolic support. ### Who benefits most from cloudberry vine supplementation? Cloudberry vine is most beneficial for individuals seeking antioxidant and anti-inflammatory support, those concerned with cellular aging, and people looking to support cardiovascular and metabolic health. It may be particularly valuable for those with limited access to northern berries or those seeking concentrated phytochemical benefits beyond what diet alone provides. Individuals with active lifestyles or cognitive demands may also benefit from its potential to support mental clarity. ### What form of cloudberry vine extract offers the best bioavailability? Standardized extracts of cloudberry vine typically offer superior bioavailability compared to whole plant material, as extraction concentrates the active polyphenols and increases their absorption potential. Dual-extraction methods (combining water and alcohol extraction) are often preferred to capture both water-soluble and fat-soluble compounds, enhancing the full spectrum of bioactive constituents. The bioavailability can be further enhanced when cloudberry vine is consumed with dietary fats, which support the absorption of fat-soluble antioxidant compounds. ## References Sources: https://pubmed.ncbi.nlm.nih.gov/35189423; https://www.sciencedirect.com/science/article/pii/S2213453021001839; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7345198/ --- *Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com* *License: CC BY-NC-SA 4.0 — Attribution required. Commercial use: admin@hermeticasuperfoods.com*