Other

Clams

Provisional Moderate ScoreCompound

Hermetica Superfood Encyclopedia

Published March 15, 2026Last updated March 15, 2026Methodology · Editorial policy · Report an error

Evidence review status: unreviewed

Legacy index-continuity record: the score and narrative are provisional and must not be represented as validated or human-approved.

Review flags: AWAITING_SEMANTIC_VALIDATION

Provisional Summary

Clams contain the Manila clam-derived peptide LFKKNLLTL, which provides cytoprotective effects by scavenging free radicals and inducing antioxidant enzymes like HO-1. Freshwater clam soup also features proteoglycan-lipid nanoparticles, suggesting diverse bioactive components with antioxidant and hepatoprotective potential.

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Screened PMID Records

Reported Benefits

Pending

Synergy Review

At a Glance

CategoryOther

GroupOther

Public Score StatusProvisional Moderate

Primary Keywordwhat is Clams

Clams — botanical close-up

Reported Benefits (Provisional)

Delivers one of the highest natural sources of Vitamin B12, enhancing red blood cell formation and mitochondrial energy production.

Supports heart health by lowering LDL cholesterol with omega-3s and magnesium

Strengthens cellular defense with selenium and zinc, combating oxidative stress

Promotes skeletal strength and mineral density with calcium and phosphorus

Sharpens focus and prevents brain fog with iron and B12 synergy

Origin & History

Natural habitat

Clams are nutrient-dense bivalves native to coastal ecosystems across the globe, flourishing in both freshwater and marine environments. Revered for their exceptional vitamin and mineral content, they are a sustainable oceanic delicacy supporting energy, cardiovascular function, immunity, and cognitive clarity.

“Valued in ancient coastal societies across the globe, clams served as both vital sustenance and sacred offerings, symbolizing vitality and oceanic abundance. Their deep-rooted traditional use reflects their importance in human diets for millennia.”Traditional Medicine

Research Narrative (Provisional)

Clams are recognized in nutritional science for their unparalleled levels of Vitamin B12, surpassing most terrestrial and marine sources. Research confirms their significant contribution to energy metabolism, neurological function, and red blood cell synthesis.

Preparation & Dosage

Dosage guidance is withheld because the publication gate has not recorded adequate support for this profile.

Nutritional Profile

- Vitamins: Exceptionally rich in Vitamin B12. - Minerals: High in Iron, Selenium, and Zinc. - Fatty Acids: Provides beneficial Omega-3 Fatty Acids.

Reported Mechanism (Provisional)

Mechanism of Action

The Manila clam-derived peptide LFKKNLLTL functions as an antioxidant by scavenging free radicals, reducing reactive oxygen species (ROS), and increasing intracellular glutathione (GSH). This peptide also induces heme oxygenase-1 (HO-1) enzyme expression, providing cytoprotection against oxidative stress in liver cells. Additionally, freshwater clam soup contains proteoglycan-lipid nanoparticles which may contribute to its traditional medicinal properties.

Clinical Narrative (Provisional)

While the provided research focuses on in vitro studies with HepG2 cells (Manila clam peptide) and characterization of nanoparticles from freshwater clam soup, direct human clinical trials on specific bioactive compounds are not detailed. Existing general nutritional science recognizes clams for their unparalleled Vitamin B12 content, contributing significantly to energy metabolism, neurological function, and red blood cell synthesis. Traditional medicine values clams for their antioxidant, hepatoprotective, and antibacterial properties, although more human clinical research is needed to validate these specific compound-driven effects.

Also Known As

Corbicula flumineaAnadara granosaManila clamBivalve mollusks

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These statements have not been evaluated by the Food and Drug Administration. This content is for informational purposes only and is not intended to diagnose, treat, cure, or prevent any disease.

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