Hermetica Superfood Encyclopedia
The Short Answer
A traditional Indian plant extract clinically studied for accelerating bone healing, reducing joint pain, and supporting healthy weight management.
CategoryOther
GroupOther
Evidence LevelStrong
Synergy Pairings4
Health Benefits
Accelerates bone fracture healing by promoting osteoblast activity and collagen synthesis.
Reduces joint inflammation and pain through modulation of inflammatory pathways
Improves metabolic balance by supporting healthy glucose and lipid metabolism
Supports hormonal regulation, particularly in relation to stress and weight management.
Soothes digestive discomfort and supports gut lining integrity
Protects cells from oxidative damage with its rich antioxidant profile
Origin & History
Cissus quadrangularis is a perennial plant native to the arid regions of India, Sri Lanka, Southeast Asia, and Africa. Revered in traditional medicine, it is valued for its exceptional capacity to accelerate bone healing, reduce joint inflammation, and support metabolic and hormonal balance.
“Known as "Hadjod" or "bone joiner" in traditional Indian medicine, Cissus quadrangularis has been revered in Ayurveda and Siddha medicine for centuries. It was prized by yogis and warriors for its ability to enhance musculoskeletal strength and tissue healing, symbolizing resilience and structural clarity.”Traditional Medicine
Scientific Research
Scientific studies, including those referenced in PubMed and ScienceDirect, have investigated Cissus quadrangularis for its bone-healing properties, anti-inflammatory effects, and metabolic support. Research highlights its potential in musculoskeletal health and weight management.
Preparation & Dosage
Common Forms
Traditionally boiled in milk or ghee, applied as a paste, or decocted; modern forms include capsules, powders, and adaptogenic tonics.
Traditional Applications
Used in Ayurveda and Siddha medicine for fractures, ulcers, hemorrhoids, and general vitality.
Dosage
300–800 mg/day of standardized extract (2
Recommended dosage is .5% ketosteroids) or 1–2 teaspoons of powdered stem.
Nutritional Profile
- Phytochemicals: Contains ketosteroids, quercetin, triterpenoids, phytosterols, mucilage, and stilbenes (including resveratrol derivatives).
- Vitamins: Rich in Vitamin C and carotenoids.
- Minerals: Provides calcium, phosphorus, and magnesium.
Synergy Stack
Hermetica Formulation Heuristic
Functional whole-food/ingredient
Bone & Joint | Energy & Metabolism
Frequently Asked Questions
What is Cissus quadrangularis?
Cissus quadrangularis is a perennial vine native to India, Southeast Asia, and Africa, used for centuries in Ayurvedic and Siddha medicine. It is best known for its ability to accelerate bone fracture healing and support joint and metabolic health.
What is the recommended dosage and is it safe?
Most clinical studies use 300–600 mg per day of a standardized extract (2.5% ketosteroids), taken with meals. It is generally well tolerated but may lower blood sugar, so individuals on diabetes medications should consult a healthcare provider.
How does Cissus quadrangularis compare to glucosamine for joint health?
While glucosamine primarily supports cartilage repair, Cissus quadrangularis works through anti-inflammatory pathways and also promotes osteoblast activity for bone healing. Some studies suggest it may also aid weight management, offering a broader range of musculoskeletal and metabolic benefits.
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