# CherryPURE (Prunus avium)

**Canonical URL:** https://ingredients.hermeticasuperfoods.com/ingredients/cherrypure
**Data Source:** Hermetica Superfoods Ingredient Encyclopedia
**Updated:** 2026-03-19
**Evidence Score:** 2 / 10
**Category:** Other
**Also Known As:** Prunus avium, Sweet Cherry, Wild Cherry, Gean, Mazzard Cherry, Bird Cherry, European Cherry

## Overview

CherryPURE is a concentrated Montmorency tart cherry (Prunus avium) extract standardized for anthocyanins, particularly cyanidin-3-glucoside and cyanidin-3-rutinoside, which drive its antioxidant and [anti-inflammatory](/ingredients/condition/inflammation) activity. These polyphenols inhibit cyclooxygenase enzymes (COX-1 and COX-2) and neutralize free radicals, supporting exercise recovery and [oxidative stress](/ingredients/condition/antioxidant) reduction.

## Health Benefits

• [Antioxidant activity](/ingredients/condition/antioxidant) demonstrated in laboratory studies with reducing power of 11.9 mg AAE/g and DPPH radical scavenging of 16.8 mg TE/g (preliminary evidence only)
• Potential [antimicrobial](/ingredients/condition/immune-support) effects from branch extracts shown in vitro (no human data available)
• Traditional use for cough suppression attributed to cyanogenic glucoside content (no clinical validation)
• May support nervous system based on historical use for nervous irritability (traditional evidence only)
• Possible digestive support historically used for dyspepsia (no modern clinical evidence)

## Mechanism of Action

CherryPURE's primary bioactives, cyanidin-3-glucoside and cyanidin-3-rutinoside, inhibit cyclooxygenase-1 and cyclooxygenase-2 enzymes, reducing prostaglandin synthesis and dampening the inflammatory cascade. These anthocyanins also scavenge [reactive oxygen species](/ingredients/condition/antioxidant) (ROS) directly, with in vitro data showing a DPPH radical scavenging capacity of 16.8 mg Trolox equivalents per gram and a reducing power of 11.9 mg ascorbic acid equivalents per gram. Additionally, anthocyanins may modulate NF-κB signaling, further suppressing [pro-inflammatory cytokine](/ingredients/condition/inflammation) expression at the transcriptional level.

## Clinical Summary

In vitro laboratory studies confirm CherryPURE's [antioxidant](/ingredients/condition/antioxidant) potency, measuring DPPH radical scavenging at 16.8 mg TE/g and reducing power at 11.9 mg AAE/g, though these results do not directly translate to human bioavailability. Human clinical data on CherryPURE as a branded ingredient remains limited, but research on Montmorency tart cherry concentrates generally suggests benefits for post-exercise muscle recovery and [inflammation](/ingredients/condition/inflammation) reduction in small trials (typically 10–54 participants). Branch extracts have shown [antimicrobial](/ingredients/condition/immune-support) activity against select bacterial strains in vitro, with no human trials currently validating this application. Overall, evidence is preliminary-to-moderate; larger randomized controlled trials are needed to establish definitive efficacy and optimal dosing.

## Nutritional Profile

CherryPURE (Prunus avium) is a concentrated tart cherry powder standardized to high anthocyanin content. Key bioactive compounds include anthocyanins (primarily cyanidin-3-glucoside and cyanidin-3-rutinoside) at approximately 50-60 mg per gram of concentrate, representing a significant concentration uplift versus whole fruit (whole sweet cherries contain ~82-297 mg anthocyanins per 100g fresh weight). Contains polyphenols including quercetin (~7-9 mg/100g fresh fruit equivalent), chlorogenic acid, and hydroxycinnamic acids contributing to the measured [antioxidant](/ingredients/condition/antioxidant) reducing power of 11.9 mg AAE/g and DPPH radical scavenging of 16.8 mg TE/g. Cyanogenic glucosides (primarily prunasin and amygdalin) are present predominantly in bark and seed fractions; fruit flesh concentrations are markedly lower and considered negligible at typical serving doses. Melatonin is naturally present in Prunus avium at approximately 0.1-13 ng/g fresh weight, which may contribute to [nervous system support](/ingredients/condition/stress) claims. Carbohydrate content in the powdered concentrate is primarily from fruit sugars (glucose, fructose, sorbitol); fiber content is minimal post-processing. Micronutrient contribution at typical supplement doses (480-500 mg powder) is limited: trace potassium (~10-15 mg/dose), vitamin C (~1-2 mg/dose). Bioavailability of anthocyanins from cherry sources is generally low (estimated 1-5% absorption), though cyanidin-3-rutinoside demonstrates moderate intestinal uptake; co-ingestion with food may modestly improve absorption via slowed gastric transit.

## Dosage & Preparation

No clinically studied dosage ranges for CherryPURE in humans have been established. Laboratory extraction studies used 825 mg plant material in 36 mL 70% ethanol, but no standardization for commercial forms exists. Consult a healthcare provider before starting any new supplement.

## Safety & Drug Interactions

CherryPURE is generally considered safe for most healthy adults when used as directed, with tart cherry products having a long history of food use and no serious adverse events reported at typical supplement doses. Individuals taking anticoagulants such as warfarin should exercise caution, as anthocyanins may have mild platelet-inhibiting properties that could potentiate bleeding risk. Those with known salicylate sensitivity should note that cherries contain natural salicylates, which may trigger reactions in sensitive individuals. Safety data during pregnancy and lactation is insufficient, so use during these periods should be avoided without medical supervision.

## Scientific Research

No human clinical trials, RCTs, or meta-analyses specifically on CherryPURE were identified in the available research. Current evidence is limited to in vitro [antioxidant activity](/ingredients/condition/antioxidant) studies showing total phenolic content of 14.6 mg GAE/g and total flavonoid content of 24.8 mg QE/g in cherry waste extracts.

## Historical & Cultural Context

Prunus avium (sweet cherry) has historical use in traditional medicine for cough suppression, nervous irritability, and dyspepsia, attributed to the cyanogenic glucoside prunasin. Modern interest focuses primarily on waste valorization for [antioxidant](/ingredients/condition/antioxidant) compounds rather than traditional medicinal applications.

## Synergistic Combinations

Vitamin C, quercetin, grape seed extract, resveratrol, green tea extract

## Frequently Asked Questions

### What is CherryPURE and how is it different from regular tart cherry juice?

CherryPURE is a concentrated, standardized Montmorency tart cherry powder derived from Prunus avium, specifically processed to preserve high levels of anthocyanins such as cyanidin-3-glucoside and cyanidin-3-rutinoside. Unlike regular tart cherry juice, which has variable polyphenol content and high sugar load, CherryPURE provides a consistent, measurable anthocyanin dose in a low-calorie powder or capsule form, making it more practical for supplementation.

### What does CherryPURE do for muscle recovery after exercise?

CherryPURE's anthocyanins inhibit COX-1 and COX-2 enzymes and scavenge exercise-induced reactive oxygen species, both of which contribute to delayed onset muscle soreness (DOMS) and inflammation. Studies on Montmorency tart cherry concentrates in athletes suggest reductions in markers of muscle damage such as creatine kinase and perceived soreness, though most trials are small (under 55 participants) and use varying dosing protocols. CherryPURE is typically studied at doses equivalent to roughly 480 mg of concentrated extract per day.

### How much CherryPURE should I take per day?

No universally established clinical dosing guideline exists specifically for CherryPURE as a branded ingredient, but research on Montmorency tart cherry concentrates suggests doses equivalent to approximately 480 mg of concentrated powder or 8–12 oz of tart cherry juice daily are commonly used in studies. Manufacturers typically recommend 480 mg per day, often split into two doses around exercise. Always follow product-specific labeling and consult a healthcare provider for personalized guidance.

### Does CherryPURE have antimicrobial properties?

In vitro studies on Prunus avium branch extracts have demonstrated antimicrobial activity against select bacterial strains, attributed to polyphenolic compounds including anthocyanins and hydroxycinnamic acid derivatives. However, these findings come exclusively from laboratory cell-based experiments with no human clinical trials to date, meaning the real-world antimicrobial relevance of oral CherryPURE supplementation remains unproven. This application should be considered highly preliminary until controlled human studies are conducted.

### Can CherryPURE interact with any medications?

CherryPURE may interact with anticoagulant medications such as warfarin or antiplatelet drugs like aspirin and clopidogrel, because anthocyanins possess mild platelet-aggregation-inhibiting properties that could amplify bleeding risk. There is also theoretical concern about interactions with NSAIDs, since both share COX-inhibiting mechanisms and concurrent use may exaggerate gastrointestinal effects. Individuals on blood pressure medications or diabetes drugs should monitor closely, as tart cherry polyphenols may have mild hypotensive and insulin-sensitizing effects observed in preliminary research.

### What is the research quality and evidence strength for CherryPURE's antioxidant claims?

CherryPURE has demonstrated antioxidant activity in laboratory studies, with a reducing power of 11.9 mg AAE/g and DPPH radical scavenging capacity of 16.8 mg TE/g; however, this preliminary in vitro evidence has not yet been validated in human clinical trials. Most claims about its antioxidant benefits remain supported by test-tube data rather than robust human studies, meaning real-world effectiveness in the body is still being established.

### Is CherryPURE safe for children and during pregnancy?

Safety data for CherryPURE in children and pregnant women is limited and not well-established in clinical research. Before giving CherryPURE to children or using it during pregnancy or breastfeeding, consult with a healthcare provider to assess individual safety and appropriateness.

### What form of CherryPURE offers the best bioavailability and absorption?

CherryPURE is a concentrated extract form of Prunus avium (sweet cherry), which is designed to provide higher concentrations of beneficial compounds compared to whole fruit or juice; however, specific bioavailability comparisons between different CherryPURE formulations (powder, liquid, capsule) have not been extensively published. The optimal absorption may depend on whether the product is taken with food and individual digestive factors, so following the manufacturer's recommended use instructions is advisable.

---

*Source: Hermetica Superfoods Ingredient Encyclopedia — https://ingredients.hermeticasuperfoods.com*
*License: CC BY-NC-SA 4.0 — Attribution required. Commercial use: admin@hermeticasuperfoods.com*